Zytologische und histologische Untersuchungsmethoden bei Lungentumoren

Abstract

The accuracy of different histological and cytological methods were analysed in 240 patients with primary lung cancer. The diagnosis had been confirmed by either biopsy, surgery or autopsy. Using multiple diagnostic procedures a positive pre-operative diagnosis was obtained in 86.5%. Where the tumour was endoscopically visible and accessible to direct biopsy the correct diagnosis was made in 97.5%. In case of more peripheral tumour localisation positive results were obtained by cytological tests in 76.5%. The most accurate method of diagnosis was direct forceps biopsy of visible tumours (91% positive). Bronchial washing was positive in 64%, post-bronchoscopic sputum analysis in 60%, pre-bronchoscopic sputum in 55% and bronchial brushing in 30%.

Comparison of the Sensitivity of Sputum and Brush Cytology in the Diagnosis of Lung Carcinomas

“…Except for the small number of small cell carcinomas in our study, brush material had a higher diagnostic yield than sputum samples in all the other tumor types (Table IV). A thorough literature review for sputum 1,5,10,12,13,17,19,22,28,30,31,34,35,38,43,47,49,53,[61][62][63] and for brush cytology 1,8,28,30,41,48,61,62 also supported our findings that squamous cell carcinomas are the type with the highest detection rate by both techniques (Table IV). The main reason for the greater detectability of this tumor type could be that squa- The tumor stage-associated sensitivity of the diagnostic techniques is also of utmost importance in early lung carcinoma detection.…”