Zytologische Untersuchung des Hodens durch Aspirationsbiopsie zur Beurteilung der Fertilität

Obrant, Karl Ola; Persson, Petra

doi:10.1159/000279375

Cited by 42 publications

(10 citation statements)

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“…I pgil, LH 0.4-2.5 pgll, prolactin < 26.8 &I, and T > 12 nmol/l. The procedure has been described in detail elsewhere [18]. In summary, a clinical investigation of both testes was performed prior to the removal of the biopsies.…”

Section: Methodsmentioning

confidence: 99%

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Cellular Localization of the Mn²⁺-Dependent Adenylyl Cyclase in the Human Testis

Gordeladze¹,

Åbyholm²,

Cusan³

et al. 1982

Archives of Andrology

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An examination of the activity of the Mn2+-dependent adenylyl cyclase (AC) in fine needle biopsies from human testes was made. Simultaneously the DNA distribution patterns in suspensions of testicular cells derived from the same patients have been determined. The DNA distribution patterns were estimated by microflow fluorimetry (MFF) after staining with fluorochrome (ethidium bromide). Thus, AC activity could be assessed and correlated with the relative number of haploid (1C = spermatids), diploid (2C = spermatogonia and testicular somatic cells), and tetraploid (4C = primary spermatocytes) cells. Testicular Mn'+-dependent AC activities varied between 0 and 8.4 pmol cyclic adenosine monophosphate (cAMP)/mg proteidmin and were highly correlated with the contents of haploid (IC) germ cells (spermatids) (r = 0.62, p < 0.01). There was no correlation between Mn2+-dependent AC activity and diploid or tetraploid cells. This indicates that the Mn'+-dependent AC activity in the human testis, like in the rat and mouse, may be exclusively localized to haploid germ cells. An inverse correlation between plasma FSH and Mn'+-dependent AC activities indicated reduced inhibin secretion in situations where the Sertoli cells did not maintain the testicular germ cell production.

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Section: Methodsmentioning

confidence: 99%

“…It should be emphasized that five out of six patients displaying elevated plasma FSH revealed abnormal testes on clinical observation ( Table 1 , patients no. 12, [17][18][19][20]. Furthermore, LH, prolactin, and testosterone plasma levels were normal except for marginally elevated prolactin in one patient (no.…”

mentioning

confidence: 99%

Cellular Localization of the Mn²⁺-Dependent Adenylyl Cyclase in the Human Testis

Gordeladze¹,

Åbyholm²,

Cusan³

et al. 1982

Archives of Andrology

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“…five men (mean age 65.2 years, range 58-72) with advanced prostate cancer and who underwent bilateral Later, fine-needle aspiration (FNA) of the testis, pioneered by Obrant and Persson [7], was proposed as a nonorchidectomy. The testis to be examined was exposed surgically invasive technique but did not become a routine clinical method either, although it is a relatively non-traumatic under local anaesthesia (including spermatic-cord infiltration) and punctured at least twice with a 23 G needle.…”

Section: Introductionmentioning

confidence: 99%

Assessment of testicular cytology by fine‐needle aspiration and the imprint technique: are they reliable diagnostic modalities?

Odabaş¹,

Uğraş²,

Aydın³

et al. 1997

British Journal of Urology

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Objective To investigate whether testicular cytology may FNA smears. There was complete agreement between the results of imprint smears and histological findings be considered diagnostic in the evaluation of infertile men.in those patients with SCO syndrome and spermatogenic arrest. There were no evident differences in sperm Patients and methods Specimens of testicular tissue obtained either surgically (imprint smear) or through counts between hypospermatogenesis and normal spermatogenesis on the imprint slides, but FNA smears fine-needle aspiration (FNA) were used as a source of cytological smears; 58 testes from 24 men with azoosdetected this difference. Conclusion FNA of the testis is a relatively non-invasive permia or severe oligospermia and from five men with advanced prostate cancer were evaluated cytologically and reproducible technique for evaluating qualitative and quantitative cytology. However, it is insufficient and compared with the histological diagnosis. Results FNA caused no apparent trauma. The results for diagnosing some testicular pathologies. Imprint smears supplement the histological diagnosis, especifrom FNA smears generally agreed with the histological findings but four patients with no spermatozoa in ally if the histological slides are stained unsatisfactorily. the FNA smears were diagnosed histologically as hypospermatogenic and two others judged histologically as Keywords Testicular cytology, fine-needle aspiration, imprint smears having Sertoli-cell-only (SCO) syndrome and spermatogenic arrest had detectable spermatozoa in theirThe purpose of the present investigation was to com-

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“… 1 2 Open testicular biopsy has been used for decades for assessment of intratesticular steroid concentrations in infertile men, but is too invasive for evaluation of normal healthy men and requires general anesthesia which might profoundly affect the results. 3 4 Testicular fine-needle aspiration (FNA) was first developed for its role in the evaluation of male infertility in 1965, 5 and became more widely used as a diagnostic procedure in the 1990s. 6 In 2001, Jarow and colleagues adapted this minimally invasive percutaneous FNA technique for the measurement of intratesticular hormones in normal, healthy men.…”

Section: Introductionmentioning

confidence: 99%

Testicular fine-needle aspiration for the assessment of intratesticular hormone concentrations

et al. 2016

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Measurement of intratesticular sex steroid concentrations in men informs both the development of male hormonal contraceptives and the understanding of male infertility. Given the challenges of using invasive techniques to measure testicular hormone physiology, our group has used a minimally-invasive fine-needle aspiration technique to measure intratesticular hormones in normal healthy men. Herein, we present a post-hoc analysis of the safety and efficacy of testicular fine-needle aspiration (FNA) completed as part of six clinical trials. From 2001 through 2011, a total of 404 procedures were conducted among 163 research volunteers, 85.9% of which were successful in obtaining sufficient fluid for the measurement of intratesticular steroid concentrations. Pain was the most common side effect, with 36.8% of procedures associated with moderate procedural pain and 4.7% with severe procedural pain. Postprocedural pain was uncommon and abated within a few days. Mild local bruising occurred with 14.9% of procedures. Two serious adverse events (0.5%) required surgical intervention. The risk of an adverse event was not associated with age, body mass index, testicular size, or the volume of fluid aspirated. Testicular FNA to obtain fluid for measurement of intratesticular steroid concentrations frequently causes mild to moderate procedural pain, but serious adverse events occur rarely. Testicular FNA has been instrumental for defining human intratesticular hormone physiology and is a minimally-invasive, safe, effective method for obtaining fluid for research on testicular physiology and pathology.

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Zytologische Untersuchung des Hodens durch Aspirationsbiopsie zur Beurteilung der Fertilität

Cited by 42 publications

References 0 publications

Cellular Localization of the Mn²⁺-Dependent Adenylyl Cyclase in the Human Testis

Cellular Localization of the Mn²⁺-Dependent Adenylyl Cyclase in the Human Testis

Assessment of testicular cytology by fine‐needle aspiration and the imprint technique: are they reliable diagnostic modalities?

Testicular fine-needle aspiration for the assessment of intratesticular hormone concentrations

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Zytologische Untersuchung des Hodens durch Aspirationsbiopsie zur Beurteilung der Fertilität

Cited by 42 publications

References 0 publications

Cellular Localization of the Mn2+-Dependent Adenylyl Cyclase in the Human Testis

Cellular Localization of the Mn2+-Dependent Adenylyl Cyclase in the Human Testis

Assessment of testicular cytology by fine‐needle aspiration and the imprint technique: are they reliable diagnostic modalities?

Testicular fine-needle aspiration for the assessment of intratesticular hormone concentrations

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Product

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Cellular Localization of the Mn²⁺-Dependent Adenylyl Cyclase in the Human Testis

Cellular Localization of the Mn²⁺-Dependent Adenylyl Cyclase in the Human Testis