α-2b interferon and oral clodronate for Gorham's disease

Gorham Disease of the Spine: A Case Report and Treatment Strategies for This Enigmatic Bone Disease

“…Clodronate and α-2b interferon prescribed after operation with radiotherapy ceased a progressive spinal deformity and decreased a pleural chylous effusion (Hagberg et al 1997). In the present case, bisphosphonate was used expecting prevention of the spine from further resorption (Hagberg et al 1997). However, its effect could not be confirmed radiographycally.…”

“…As no evidence of bony healing or no obvious progression of the disease was detected, the patient had remained in a halo jacket for 30 months. Clodronate and α-2b interferon prescribed after operation with radiotherapy ceased a progressive spinal deformity and decreased a pleural chylous effusion (Hagberg et al 1997). In the present case, bisphosphonate was used expecting prevention of the spine from further resorption (Hagberg et al 1997).…”

“…Only 28 cases, to our knowledge, have been reported in the English literature (Table 1) (Bickel and Broders 1947;Gorham and Stout 1955;Falkmer and Tilling 1956;Hambach et al 1958;Castleman and McNeely 1964;Ellis and Adams 1971;Thompson and Schurman 1974;Heyden et al 1977;Woodward et al 1981;Heffez et al 1983;Brown et al 1986;Bohlman et al 1986;Hejgaard and Olsen 1987;Joseph and Bartal 1987;Mitchell et al 1993;Drewry et al 1994;Halliday et al 1994;Stöve and Reichelt 1995;Aoki et al 1996;Livesley et al 1996;Chung et al 1997;Hagberg et al 1997;Mawk et al 1997;Benhalima et al 2001;Bode-Lesniewska et al 2002;Chong and Shell 2003;Ceroni et al 2004). Eighteen patients were males and 10 patients were females.…”

“…Their results were discouraging (Castleman and McNeely 1964;Woodward et al 1981;Drewry et al 1994;Aoki et al 1996;Livesley et al 1996;Hagberg et al 1997;Bode-Lesniewska et al 2002;Chong and Shell 2003). Every spine was not fused by the initial operation and the grafted bones were absorbed.…”

“…Every spine was not fused by the initial operation and the grafted bones were absorbed. After multiple operations, 5 cases could obtain stable spine (Castleman and McNeely 1964;Drewry et al 1994;Aoki et al 1996;Hagberg et al 1997;Chong et al 2003). In affected bones in the extremities, amputation or massive prosthetic replacement can be chosen to eradicate their destructive processes (Cannon et al 1986;Joseph and Bartal 1987;Livesley et al 1996).…”