α¯ Aminoisobutyric Acid Leads a Fluorescent syn-bimane LASER Probe Across the Blood-brain Barrier

Lapidot, Inbal; Baranes, Danny; Pinhasov, Albert; Gellerman, Gary; Albeck, A.; Grynszpan, Flavio; Shatzmiller, Shimon

doi:10.2174/1573406411666150518105010

Cited by 9 publications

(8 citation statements)

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“…Today, two agents (see below) that might be useful as probes to detect their biomarkers of neurodegenerative diseases were prepared by two groups. Recently, such small molecules that could be supplied to the brain via the blood streams (abdominal or tail injection) have been reported by an Israeli and a Korean groups and introduced to the inner brain by crossing the blood brain barrier (BBB) [62,63].…”

Section: Styrylbenzene Derivative and Ethidium Bromidementioning

confidence: 99%

Glutathione As Biomarker for Neurodegenerative Diseases

2020

J B & Bio Engine;

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Brain imaging is one of the main obstacles of modern disease diagnostics since it must allow accurate and quantitative measurements on a living organ that is placed in adults (in neonatal humans’ skull penetration is somewhat easier) inside a bone cage. Inside is the brain, the main function controller of our body that must be done in a non- invasive way on the living operation brain. Many spectroscopic methods are trying to overcome the difficult access to the brain: Photoacoustic microscopy, Confocal microscopy, Two-photon microscopy, Optical coherence tomography, Scanning Laser Acoustic Microscopy, Acoustic microscopy, Ultrasonography, positron tomography, fluorescence methods, photo caustic microscopy and multi (two) photon imaging spectroscopy. The situation is complex since the brain is wrapped in the blood brain barrier allowing only selected molecules to pass from the blood stream to and out of the brain. In this chapter, we will survey the current situation of brain diagnostics with the aid of the spectroscopic methods. Brain research is integrated in aging research as a major area of interest. Aging is in most cased coupled with the loss of brain function and dementia. The neurodegenerative diseases, although identified by Dr. Alzheimer and his collaborators more than a century ago, continue as the leading causes of mortality among the elderly. Brain research in trying to give hope to those people but unfortunately our understanding in this area is limited. Oxidative stress contributes to neurodegenerative diseases pathophysiology and progression. The target was to describe central and peripheral metabolites of redox metabolism and to describe correlations between glutathione status, age, and disease severity.

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Section: Styrylbenzene Derivative and Ethidium Bromidementioning

confidence: 99%

Glutathione As Biomarker for Neurodegenerative Diseases

2020

J B & Bio Engine;

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“…The penetration of microbes into the inner brain can be the Currently, many agree that the gut microbiome reaches the brain using the "gut-brain axis" and is the cause for the onset of neurodegeneration -this penetration results in inflammation, then infection and apoptosis of the brain tissue. Antimicrobial peptide surrogates [15,16], based on a brain-penetrating scaffold-like diazepine [17,18] or 1,4 dihydropyridine [19][20][21] may be suitable to combat the invading microbiota and in a later stage serve as antimicrobial agents to combat the infection and prevent aggregation [22]. It was shown that some selectivity in bacteria eradication was possible [23].…”

Section: Figurementioning

confidence: 99%

Combatting the Pathological Brain Microbiome

Shatzmiller¹

2019

Act Scie Neuro

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Substances that come from nutrients, to combat inflammation and the crawling infection might be a proper approach to treat The quest of remedy for neurodegenerative diseases is already more than a century old. It is unclear, applying the moist sophisticated ultramodern methods and equipment, what is in fact going on in the human brain when this curse hits. However, Nowadays the perception is that gut microbiome penetrates the brain via the "Gut-Brain" axis. Either by using nerves or through the bloodstream by moving from a leaky gut to a damaged blood-brain barrier. Moreover, when in the brain, causing inflammation and subsequent infection, that moves in the brain in a prion-like a mechanism, from one cell to its neighbor until interoception (death) is reached.The eradication of bacteria antimicrobial peptide surrogates in synergy with antioxidants, neurodegeneration at its early stages.Like other parts of our body, the brain is home to bacteria, viruses and fungus, such as yeast and larger parasites such as amoebas.This changes the clinical landscape of many conditions, including autism, neurodegenerative disease such as Alzheimer's and Parkinson's and chronic inflammatory response syndromes (CIRS). It also forces us to consider the 'mind', 'self', and 'agency' blurring the lines between science and philosophy.

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“…These sensors, which operate in both solution-state and on filter papers to provide fluorometric and colorimetric analyte detection, have notable practical advantages, including their high sensitivity, ease of access, and non-toxicity of both the bimane transducing element and supramolecular cyclodextrin scaffold. The lack of toxicity of both cyclodextrin ( Kfoury et al, 2019 ) and bimane (MSDS 38369) has been well-established in the literature, and has led to the use of both of these components in a variety of biologically-relevant applications ( Barbosa et al, 2019 ; Lapidot et al, 2016 ; Lavis and Raines 2008 ). Moreover, an additional report from one of our research groups has demonstrated a streamlined approach to access bimane derivatives, which facilitates practically attainable access to a variety of these highly fluorescent structures ( Szumski et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Water Detection Through Reversible Fluorescence Changes in a syn-Bimane Based Boronic Acid Derivative

et al. 2022

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Reported herein is a fluorometric and colorimetric sensor for the presence of trace amounts of water in organic solvents, using syn-bimane based boronate ester 1. This sensor responds to the presence of water with a highly sensitive turn-off fluorescence response, with detection limits as low as 0.018% water (v/v). Moreover, analogously high performance was observed when compound 1 was adsorbed on filter paper, with the paper-based sensor responding both to the presence of liquid water and to humid atmospheres. Reusability of the paper-based sensor up to 11 cycles was demonstrated, albeit with progressive decreases in the performance, and 1H NMR and mass spectrometry analyses were used to explain the observed, hydrolysis-based sensor response.

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α¯ Aminoisobutyric Acid Leads a Fluorescent syn-bimane LASER Probe Across the Blood-brain Barrier

Cited by 9 publications

References 0 publications

Glutathione As Biomarker for Neurodegenerative Diseases

Glutathione As Biomarker for Neurodegenerative Diseases

Combatting the Pathological Brain Microbiome

Highly Sensitive Water Detection Through Reversible Fluorescence Changes in a syn-Bimane Based Boronic Acid Derivative

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