α‐Aminophosphonates and α‐Aminophosphine Oxides by the Microwave‐Assisted Kabachnik–Fields Reactions of 3‐Amino‐6‐methyl‐2 <i>H</i>‐pyran‐2‐ones

Bálint, Erika; Takacs, J. M.; Drahos, László; Juranovič, Amadej; Kočevar, Marijan; Keglevich, György

doi:10.1002/hc.21086

Cited by 33 publications

(18 citation statements)

References 26 publications

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“…A few N-(2H-pyranonyl)-α-aminophosphonates or -α-aminophosphine oxides were also synthesized starting from 3-amino-2H-pyran-2-one derivatives [30,31]. Double "phospha-Mannich" condensations were also developed applying two equivalents of the formaldehyde and the >P(O)H species to one equivalent of the primary amine (Scheme 3) [32][33][34].…”

Section: Methodsmentioning

confidence: 99%

Environmentally Friendly Chemistry with Organophosphorus Syntheses in Focus

Keglevich

Grűn²,

Bagi³

et al. 2015

Period. Polytech. Chem. Eng.

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The use of the microwave (MW) Keywords organophosphorus chemistry, green chemistry, microwave, resolution, platinum complexes, dronic acids/dronates IntroductionIn this minireview, our recent results in environmentallyfriendly ("green") chemistry have been summarized. In the first sub-chapter the usefulness of the microwave technique is shown in organophosphorus chemistry. The second sub-chapter summarizes our results on the resolution of cyclic phosphine oxides, as precursors for P-ligands and on the synthesis of platinum complexes as potential catalysts. Catalysts are of utmost importance from the point of view of green chemistry. The last sub-chapter comprises our experiences on the optimization of the synthesis of dronic acid derivatives that are important drugs against bone diseases.

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Section: Methodsmentioning

confidence: 99%

Environmentally Friendly Chemistry with Organophosphorus Syntheses in Focus

Keglevich

Grűn²,

Bagi³

et al. 2015

Period. Polytech. Chem. Eng.

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“…Then 3-amino-6-methyl-2H-pyran-2-ones (56) were utilized in the KabachnikFields reaction with formaldehyde and dialkyl phosphites or diphenylphosphine oxide (Scheme 3.39) [75].…”

Section: The Addition Of >P(o)h Species To Carbonyl-compoundsmentioning

confidence: 99%

The Use of MW in Organophosphorus Chemistry

Keglevich

Bálint²,

Kiss

2016

SpringerBriefs in Molecular Science

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The third chapter summarizes a special field, the application of the microwave (MW) technique in the synthesis of organophosphorus compounds. On the one hand, reactions are shown that are otherwise rather reluctant on traditional thermal heating. On the other hand, reactions are discussed, which, became more efficient (shorter reaction times and higher yields) on MW irradiation. Finally, the simplification of catalytic systems under MW conditions are surveyed.

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“…In another version, amino-2H-pyran-2-ones (53) were used as the starting materials to afford interesting N-heterocyclic α-aminophosphonates or α-aminophosphine oxides (54) (Scheme 19) [72,73].…”

Section: Kabachnik-fields Reactionsmentioning

confidence: 99%