α-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish

Abstract

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Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy

“…An earlier study has reported that the natural phenylpropene, α-asarone, did not significantly affect mortality and hatching rate, whereas there was an increased malformation rate in zebrafish in a concentration-dependent pattern (Shang et al, 2020). In a similar line, we observed that Pb-exposed, and CGA, NCGA, and CCGA co-treated group exerted no effect on the hatching rate and mortality when compared with the control group.…”

“…Developmental neurotoxicity induced by Pb was assessed as per our earlier reported study (Jin et al, 2019b;Shang et al, 2020). The mortality rate evaluated from 24 to 120 hpf was identified by coagulation of the larvae.…”

Schaftoside Suppresses Pentylenetetrazol-Induced Seizures in Zebrafish via Suppressing Apoptosis, Modulating Inflammation, and Oxidative Stress

“…Seizures can lead to neuronal death via apoptosis and autophagy signaling pathway activation. , PTZ administration has been reported to increase cell death in the nervous system of rodent seizure models . Zebrafish larvae offer an advantage in investigating neuronal apoptosis. , We observed that SS treatment significantly inhibited the PTZ-induced increase in apoptotic cells in the zebrafish head and trunk, suggesting that this effect might be an underlying mechanism behind the anticonvulsant effect of SS.…”

“…A TUNEL assay was performed to assess apoptosis according to the protocol from our earlier reported study. , Zebrafish larvae at 7 dpf were fixed overnight at 4 °C in 4% paraformaldehyde (PFA). After washing with PBS, endogenous peroxidases were blocked by incubation in 3% H 2 O 2 in methanol for the duration of 15 min at room temperature.…”

Long non‑coding RNA TUG1 sponges microRNA‑9 to protect podocytes from high glucose‑induced apoptosis and mitochondrial dysfunction via SIRT1 upregulation

“…In addition, cell viability was decreased when the concentration of glucose added was increased, as well as when the incubation time with HG was increased. Previous studies have reported that lncRNA TUG1 and podocytes serve an important role in the progression of diabetic nephropathy (19,20). Therefore, it was hypothesized that HG would also affect TUG1 expression in podocytes.…”