α-Chymotrypsin inhibition studies on the lignans from <i>Vitex negundo</i> Linn

Lodhi, Muhammad Arif; Choudhary, M. Iqbal; Malik, Abdul; Ahmad, Saeed

doi:10.1080/14756360701584653

Cited by 16 publications

(8 citation statements)

References 17 publications

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“…co- , n- , and ad- multifidolglucoside ( 18a – c ), quercetin-3- O-β - d -glucoside ( 19 ), kaempferol-3- O-β - d -glucoside ( 20 ), quercetin-3- O-β - d -(6- O -malonyl)glucoside ( 21 ), and kaempferol-3- O-β - d -(6- O -malonyl)glucoside ( 22 ) were assigned by comparison of spectroscopic data with the literature and by cochromatography with the corresponding reference material isolated from a hop polyphenol extract. In addition, comparison of spectroscopic data with the literature led to the identification of 3-, 4-, and 5-feruloylquinic acid ( 12 – 14 ), N -feruloyltyramine ( 16 ), and syringaresinol ( 17 ) …”

Section: Methodssupporting

confidence: 84%

Activity-Guided Identification of in Vitro Antioxidants in Beer

Spreng

Hofmann

2018

J. Agric. Food Chem.

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In order to locate the key antioxidants contributing to oxidative stability of beer, activity-guided fractionation in combination with the oxygen radical absorbance capacity (ORAC) assay, hydrogen peroxide scavenging (HPS) assay, and linoleic acid (LA) assay was applied to a pilsner-type beer. LC-MS and 1D/2D NMR experiments led to the identification of a total of 31 antioxidants, among which 3-methoxy-4-hydroxyphenyl-β-d-glucopyranoside (tachioside), 4-(2-formylpyrrol-1-yl)butyric acid, 4-[2-formyl-5-(hydroxymethyl)pyrrol-1-yl]butyric acid, n-multifidol-3-O-β-d-glucoside, quercetin-3-O-(6″-malonyl)-glucoside, 4-feruloylquinic acid, syringaresinol, saponarin, and hordatines A-C have been isolated from beer for the first time. On a molar comparison, the hordatines A-C, saponarin, and quercetin-3-O-β-d-(6″-malonyl)glucoside were evaluated with the highest antioxidant activities of all identified beer constituents, reaching values of 10-17.5 (ORAC), 2.0-4.1 (HPS), and 1.1-6.1 μmol TE/μmol (LA) for hordatines A-C.

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Section: Methodssupporting

confidence: 84%

Activity-Guided Identification of in Vitro Antioxidants in Beer

Spreng

Hofmann

2018

J. Agric. Food Chem.

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“…Vitrofolal E ( 7 ) has also been shown to have moderate activity in the in vitro cholinesterase inhibition assay [31] and to have tyrosinase inhibitory activity in the same µM-range compared to known inhibitors [32]. Vitrofolal F ( 8 ) has been shown to have α-chymotrypsin (serine protease) inhibitory effect and has thus been suggested as a specific natural inhibitor of this enzyme [36]. The aryldihydronaphthoic acid derivative, descuraic acid ( 9 ), was isolated from seeds of Descurainia Sophia (L.) Webb ex Prantl, an annual/biennial herb [12].…”

Section: Introductionmentioning

confidence: 99%

9-Norlignans: Occurrence, Properties and Their Semisynthetic Preparation from Hydroxymatairesinol

Eklund

Raitanen

2019

Molecules

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Lignans, neolignans, norlignans and norneolignans constitute a large class of phenolic natural compounds. 9-Norlignans, here defined to contain a β–β’ bond between the two phenylpropanoid units and to lack carbon number 9 from the parent lignan structure, are the most rarely occurring compounds within this class of natural compounds. We present here an overview of the structure, occurrence and biological activity of thirty-five 9-norlignans reported in the literature to date. In addition, we report the semisynthetic preparation of sixteen 9-norlignans using the natural lignan hydroxymatairesinol obtained from spruce knots, as starting material. 9-Norlignans are shown to exist in different species and to have various biological activities, and they may therefore serve as lead compounds for example for the development of anticancer agents. Hydroxymatairesinol is shown to be a readily available starting material for the preparation of norlignans of the imperanene, vitrofolal and noralashinol family.

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“…6-hydroxy-4-(4-hydroxy-3-methoxy)-3-hydroxymethyl-7-methoxy-3,4-dihydro-2-naphthaldehyde and vitrofolal E ( Figure 20) have modest α-chymotrypsin (serine protease) competitive inhibitory effects with K i values equal to 31.75 and 47.11 µM, respectively [72].…”

Section: Inhibition On Enzymes Proteins and Platelet Aggregationmentioning

confidence: 99%

Nor-Lignans: Occurrence in Plants and Biological Activities—A Review

et al. 2020

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In this review article, the occurrence of nor-lignans and their biological activities are explored and described. Nor-lignans have proven to be present in several different families also belonging to chemosystematically distant orders as well as to have many different beneficial pharmacological activities. This review article represents the first one on this argument and is thought to give a first overview on these compounds with the hope that their study may continue and increase, after this.

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α-Chymotrypsin inhibition studies on the lignans from Vitex negundo Linn

Cited by 16 publications

References 17 publications

Activity-Guided Identification of in Vitro Antioxidants in Beer

Activity-Guided Identification of in Vitro Antioxidants in Beer

9-Norlignans: Occurrence, Properties and Their Semisynthetic Preparation from Hydroxymatairesinol

Nor-Lignans: Occurrence in Plants and Biological Activities—A Review

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