α -Ferrocenylalkyl carbonates: Reagents for ferrocenylalkylation reactions under mild neutral conditions

Ferrocenyl alkylation of 4‐mercapto derivatives of sydnones and sydnone imines. New antidotes for sulfonylurea herbicides

“…We have previously reported a convenient methodology for the ferrocenyl alkylation of alcohols, heterocyclic thiols, and amino acids with (α-ferrocenylalkyl) carbonates under mild acid-free conditions. [25][26][27][28] The application of this method not only allowed us to obtain ferrocenyl sydnone imines (Table 2) but also made it possible to solve the problem of the inertness of 4-mercaptosydnones in the alkylation reaction under the action of α-hydroxy derivatives of ferrocene. The target ferrocene-containing 4-thiosydnones 3 were obtained in moderate yields.…”

One‐pot acid‐free ferrocenylalkylation of azoles with α‐ferrocenyl alcohols: ferrocene‐based plant growth regulators and herbicide safeners

“…[25,26] Carbonates 2 spontaneously decompose under neutral conditions even at room temperature producing the αferrocenylcarbocation that interacts with the nucleophile (or pre-nucleophile) NuH furnishing the α-ferrocenylalkylation product 3 (Scheme 1). [25,26] Carbonates 2 spontaneously decompose under neutral conditions even at room temperature producing the αferrocenylcarbocation that interacts with the nucleophile (or pre-nucleophile) NuH furnishing the α-ferrocenylalkylation product 3 (Scheme 1).…”

Ferrocene‐modified imidazoles: One‐pot oxalyl chloride‐assisted synthesis, HPLC enantiomeric resolution, and in vivo antitumor effects

“…[39] Recently, a new method for the introduction of ferrocenylalkyl groups into different heterocycles has been developed; it based on the in situ production of ferrocenylalkyl carbonates. [40,41] The yields in such acidfree reactions reach 70%.…”