α-Fetoprotein in Congenital Hypothyroidism

Mengreli, Chryssanthi; Sarafidou, Emi; Petmezaki, Sophia; Pantelakis, S

doi:10.1159/000243287

Cited by 9 publications

(4 citation statements)

References 13 publications

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“…Larsson and co-workers (172) suggested that either the rate of AFP synthesis in liver is increased, or else the repression of this synthesis is delayed in the hypothyroid fetus/infant. However, Mengreli and co-workers (181) argued that the half-life of AFP is extended in these infants (12 days vs. the normal 5 days) and postulated that low T 4 levels could be responsible for a slower catabolism of SAFP in the liver. In a report predating these proposals, Belanger and co-workers (174) had demonstrated that both glucocorticoid and T4treated newborn rodents displayed depressed SAFP levels as a result of selective blockage of AFPs hepatic synthesis rather than as the result of altered serum clearance of the fetal protein.…”

Section: Afp Thyroid Hormone and Hypothyroidismmentioning

confidence: 96%

Biological Roles of Alpha-Fetoprotein During Pregnancy and Perinatal Development

Mizejewski

2004

Exp Biol Med (Maywood)

122

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The use of alpha-fetoprotein (AFP) as a serum marker in cancer actually predates its employment in the detection of congenital defects; however, the latter use of AFP as a fetal defect marker has propelled its clinical utilization. Although the serum-marker capacity of AFP has long been exploited, less is known of the biological activities of this oncofetal protein during fetal and perinatal development. In the present review, the biological activities of AFP are discussed in light of this glycoprotein's presence in various biological fluid compartments: embryonic and fetal tissues, serum, urine, and reproductive fluids. After a review of the histochemical detection of AFP in various cells and tissues during development, AFP concentrations within various biological fluids were discussed in the context of gestational age and anatomic location. Discussion follows concerning the relationships and roles of AFP in developmental events such as erthyropoiesis, histogenesis/organogenesis, and ligand binding and in developmental disorders such as hypothyroidism, folate deficiencies, and acquired immunodeficiency disorder (AIDS). Based on its association with so many types of birth defects, malformations, and congenital anomalies, AFP can be viewed as a molecular "troubleshooter" until signal transduction pathways are established during pregnancy and prenatal development. The review concludes with a discussion of the place of AFP in the rapidly expanding field of proteomics.

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Section: Afp Thyroid Hormone and Hypothyroidismmentioning

confidence: 96%

Biological Roles of Alpha-Fetoprotein During Pregnancy and Perinatal Development

Mizejewski

2004

Exp Biol Med (Maywood)

122

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“…AFP with the same concentrations as the dynamic range was reacted with the sensor on which the Tg antibodies were conjugated. AFP is used as a biomarker to diagnose and detect liver cancer, and its levels are also affected by thyroid hormones and hypothyroidism 39 . When various values of AFP were injected into the sensor chip, the changes in the LSPR intensities exhibited by the proposed sensor were minimal at all levels.…”

Section: Resultsmentioning

confidence: 99%

Design and validation of fiber optic localized surface plasmon resonance sensor for thyroglobulin immunoassay with high sensitivity and rapid detection

Kim

Jeong

Lee

et al. 2021

Sci Rep

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A simple optical fiber sensor based on localized surface plasmon resonance was constructed for direct and rapid measurement of thyroglobulin (Tg). Specific tests for Tg in patients that have undergone thyroidectomy are limited because of insufficient sensitivity, complicated procedures, and in some cases, a long time to yield a result. A sensitive, fast, and simple method is necessary to relieve the psychological and physical burden of the patient. Various concentrations of Tg were measured in a microfluidic channel using an optical fiber sensor with gold nanoparticles. The sensor chip has a detection limit of 93.11 fg/mL with no specificity for other antigens. The potential applicability of the Tg sensing system was evaluated using arbitrary samples containing specific concentrations of Tg. Finally, the sensor can be employed to detect Tg in the patient’s serum, with a good correlation when compared with the commercial kit.

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“…Serum a-fetoprotein was found to be significantly high in neonates with high TSH levels, reflecting extensive synthesis of a-fetoprotein in hypothyroid infants [9]. Mengreli et al [10] also studied infants and found that a-fetoprotein levels were significantly higher in the congenital hypothyroidism group before treatment and showed a significant rise after discontinuation of thyroxin therapy. Recently, two cases of apparently unexplained elevated MSAFP (5.3 and 7 MOM) in 17-week gestations were described in which congenital hypothyroidism (low thyroxin and high TSH levels) was diagnosed after delivery [3].…”

Section: Discussionmentioning

confidence: 99%

Maternal thyroid function does not alter maternal serum ?-fetoprotein interpretation

Hallak

O’Brien

Johnson

et al. 1997

J. Matern. Fetal Med.

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Objective Endocrine alterations of metabolism such as diabetes and obesity are known to affect maternal serum α‐fetoprotein interpretation. Thyroid function has been questioned, e.g., because of binding globulins, but not adequately studied as to its impact upon maternal serum α‐fetoprotein. The purpose of this study was to assess the possible effects of T4 and thyroid‐stimulating hormone (TSH) on α‐fetoprotein production, and to determine if thyroid function (hypothyroidism) alters maternal serum α‐fetoprotein. Methods: We evaluated maternal serum α‐fetoprotein, T4, and TSH records of 25,551 patients, between 14 and 20 weeks' gestation, on whom both studies had been ordered by the patient's primary obstetrician to rule out maternal thyroid disease in pregnancy. Statistical analyses were performed by X2 and regression analysis. Results: Patients were stratified according to thyroid function tests into two groups: hypothyroidism (T4 < 6.5 μg/dL and/or TSH > 5.0 μU/mL), and normal or hyperthyroidism (T4 ≥ 6.5 μg/dL and/or TSH ≤ 5.0 μU/mL). Maternal serum α‐fetoprotein values were compared among groups for each gestational age. No significant variation or correlation of maternal serum α‐fetoprotein and thyroid function was observed. Conclusions: Although other endocrine abnormalities are known to impact maternal serum α‐fetoprotein values either through decreased production, decreased placental permeability, or plasma volume distribution alterations, maternal thyroid status does not interfere with proper interpretation of maternal serum α‐fetoprotein. J. Matern.‐Fetal Med. 6:115–117, 1997. © 1997 Wiley‐Liss, Inc.

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α-Fetoprotein in Congenital Hypothyroidism

Cited by 9 publications

References 13 publications

Biological Roles of Alpha-Fetoprotein During Pregnancy and Perinatal Development

Biological Roles of Alpha-Fetoprotein During Pregnancy and Perinatal Development

Design and validation of fiber optic localized surface plasmon resonance sensor for thyroglobulin immunoassay with high sensitivity and rapid detection

Maternal thyroid function does not alter maternal serum ?-fetoprotein interpretation

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