α-Fetoprotein in malignant germ cell tumors of the ovary

Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

“…[63][64][65] Ultrasound is typically used for initial evaluation; however, CT is useful to assess for metastases. 57 MRI may be useful for determining malignant potential if ultrasound is not reliable.…”

“…Women younger than 35 years with a pelvic mass should have AFP levels measured to assess for germ cell tumors and to rule out pregnancy. [63][64][65] A gastrointestinal tract evaluation is recommended for mucinous histology to determine whether an occult gastrointestinal primary has metastasized to the ovaries. 80 An intraoperative frozen section evaluation is recommended for women who would like to maintain their fertility (see "Surgery," subsequent section).…”

“…The LCOH algorithms begin after surgery and histologic diagnosis of a suspicious pelvic mass (see LCOH-1; [63][64][65] For example, AFP levels should be considered to assess for germ cell tumors in women younger than 35 years with a pelvic mass. [63][64][65] Ultrasound is typically used for initial evaluation; however, CT is useful to assess for metastases.…”

Over Tümörleri̇nde Tümör Beli̇rteçleri̇ Ve Kli̇ni̇k Önemleri̇

“…Tanı için laparotomi ve histopatolojik inceleme şarttır. Hastalarda operasyon öncesi kan alınıp saklanmalı, ameliyatta tanı aynı şekilde germ hücreli tümör çıkarsa o zaman belirteçler çalışılmalıdır (44).…”

“…Alfa fetoprotein (αFP), her zaman endodermal sinus tümörleri, sıklıkla embriyonel karsinoma ve poliembriyoma ve bazen immatur teratomlar tarafından üretilen onkofetal bir glikoproteindir (44). 500µg/L'nin üstündeki değerler nadiren benign hastalıklar ile ilişkilidir (45).…”