α-Glucosidase and pancreatic lipase inhibitory activities and glucose uptake stimulatory effect of phenolic compounds from Dendrobium formosum

Inthongkaew, Prachyaporn; Chatsumpun, Nutputsorn; Supasuteekul, Chonlakan; Kitisripanya, Tharita; Putalun, Waraporn; Likhitwitayawuid, Kittisak; Sritularak, Boonchoo

doi:10.1016/j.bjp.2017.05.005

Cited by 86 publications

(93 citation statements)

References 37 publications

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“…Excessive lipid accumulation could be one of the causative factors for type II diabetes, as the accumulation of lipid in the pancreas causes dysfunction of insulin-producing pancreatic β-cells [22]. Recently, inhibitors of pancreatic lipase have attracted interest due to their ability to delay lipid digestion, and hence could act as promising anti-obesity drugs [23]. Tyrosinase is a key enzyme in the process of melanin synthesis [24,25].…”

Section: Introductionmentioning

confidence: 99%

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

et al. 2019

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Background: Blepharis linariifolia Pers. (Family: Acanthaceae) is used in traditional medicines as a general tonic and for the treatment of various health problems in Sudan. The main aim of this study was to isolate and identify the major chemical constituents from the aerial parts of B. linariifolia and evaluate their bioactivities. Methods: The dried aerial parts of the plant were extracted successively with 100% acetone and 50% acetone, and thereafter the combined extract was subjected to repeated column chromatography to isolate the main components. Free radical scavenging activity was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical method, and in vitro enzyme inhibitory activities against α-glucosidase, pancreatic lipase, and mushroom tyrosinase were evaluated. Results: From the detailed chemical analysis, verbascoside (1), vanillic acid (2), apigenin (3), and 6″-O-p-coumaroylprunin (4), were isolated and their structures were identified on the basis of their nuclear magnetic resonance (NMR) spectral data. Among the isolated compounds, verbascoside (1) showed the most potent free radical scavenging activity (IC50 = 22.03 ± 0.04 μM). Apigenin (3) and 6″-O-p-coumaroylprunin (4) showed promising inhibitory activities against all tested enzymes. Apigenin (3) showed the most potent inhibitory activity against α-glucosidase and tyrosinase (IC50 = 34.73 ± 1.78 μM and 23.14 ± 1.83 μM, respectively), whereas 6″-O-p-coumaroylprunin (4) showed potent inhibition for lipase (IC50 = 2.25 ± 0.17 μM). Conclusions: Four phenolic compounds were isolated and identified from B. linariifolia acetone extract, which are reported for the first time from this plant. All compounds showed good DPPH free radical scavenging activities, with verbascoside (1) being the most potent. Apigenin (3) was the most active as α-glucosidase and mushroom tyrosinase inhibitor, while 6″-O-p-coumaroylprunin (4) showed potent inhibitory activity for pancreatic lipase.

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Section: Introductionmentioning

confidence: 99%

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

et al. 2019

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“…5-methoxy-7-hydroxy-9,10-dihydro-1,4-phenanthrenequinone isolated from a methanol extract of the whole plant of Dendobium formosum at 50 µg/mL is related with non-competitive inhibition of alpha-glucosidase (96%) and pancreatic lipase (83%), reveling IC 50 (half maximal inhibitory concentration) values of 126.88 ± 0.66 µM, and 69.45 ± 10.14 µM, respectively [24].…”

Section: Naturally-occurring Lipase Inhibitorsmentioning

confidence: 99%

“…The inhibition of lipase leads to restored insulin production from β-cells protecting pancreas through decrease of lipid absorption. Orlistat is the most prescribed synthetic drug for the pathology, but with several side effects reported including steatorrhea, bloating, oily spotting, fecal urgency, fecal incontinence, and hepatic adverse effects [22,24,25]. Aditionally, the inhibition of fat absortion results in the need of vitamin supplementation because of the defficiency of fat-soluble vitamins in patients undergoing orlistat theraphy [22].…”

Section: Pharmacological Approachmentioning

confidence: 99%

Phytopharmacological Strategies in the Management of Type 2 Diabetes Mellitus

Duarte

Barroso

Gil

2020

Foods

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Type 2 Diabetes Mellitus (T2DM) is a chronic disease which corresponds to 90% of the worldwide cases of diabetes, mainly due to epigenetic factors such as unhealthy lifestyles. First line therapeutic approaches are based on lifestyle changes, most of the time complemented with medication mostly associated with several side effects and high costs. As a result, the scientific community is constantly working for the discovery and development of natural therapeutic strategies that provide lower financial impact and minimize side effects. This review focus on these nature-based therapeutic strategies for prevention and control of T2DM, with a special emphasis on natural compounds that present pharmacological activity as dipeptidyl peptidase-4 (DPP4), alpha-amylase, alpha-glucosidase, lipase, and protein tyrosine phosphatase 1B (PTP1B) inhibitors.

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“…Antioxidant effect of PNC was studied on the basis of the DPPH free radical scavenging effect as per literature methods [23][24][25]; hypoglycemic effect was studied by alpha amylase and alpha glucosidase inhibitory assay procedure [26,27]; hypolipidemic effect was studied by pancreatic lipase inhibitory assay [28][29][30]. Angiotensin converting enzyme (ACE) activates angiotensin-I into a potent vasoconstrictor called angiotensin-II that influences aldosterone release which increases blood pressure.…”

Section: In Vitro Studies On the Effect Of Pncmentioning

confidence: 99%

Development of a standardized combined plant extract containing nutraceutical formulation ameliorating metabolic syndrome components

De¹,

Bhandari

Katakam³

et al. 2019

SN Appl. Sci.

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Plant bioactives have a great role in combating multifactorial disease conditions like metabolic syndrome (MetS). This research work aims to develop a standardized plant extract combination and formulate it to tablets with nutraceutical potentials. The extract was prepared from the bark powder of Ficus religiosa, seed powder of Syzigium cumini and leaf powder of Ocimum bacilicum chemometrically optimized in the ratio of 1.15:1.15:1.68 (Ashwattha: Jamun: Basil or FR: SC: OB). It is enriched in screened and pharmacologically active plant secondary metabolites. The tablets were prepared by direct compression using single-punch tablet machines. The nutraceutical tablets passed all the prescribed quality control tests with a justified pharmacokinetic profile. Results of animal experimentations have shown the hypoglycemic, hypolipidemic effect and antihypertensive effect of the nutraceutical tablets in relevant animal models. Thus, the nutraceutical formulation that showed effectivity in combating MetS can be opted as an adjunct therapy.

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α-Glucosidase and pancreatic lipase inhibitory activities and glucose uptake stimulatory effect of phenolic compounds from Dendrobium formosum

Cited by 86 publications

References 37 publications

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

Phytopharmacological Strategies in the Management of Type 2 Diabetes Mellitus

Development of a standardized combined plant extract containing nutraceutical formulation ameliorating metabolic syndrome components

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