α-Glucosidase and α- amylase inhibition potentials of ten wild Mexican species of Verbenaceae

Abstract

Purpose: To evaluate the inhibitory activity of 10 wild Verbenaceae species from Mexico against αglucosidase and α-amylase. Methods: Ethanol leaf extracts of 10 Verbenaceae species from Mexico were prepared. The inhibitory activity of the extracts against α-glucosidase and α-amylase was evaluated using enzymatic protocols. At least four serial diluted concentrations of each extract was used to calculate the half-maximal inhibitory concentration (IC50). Results: The 10 evaluated Verbenaceae species showed high α-glucosidase inhibition activity, but a low inhibitory effect on α-amylase. Aloysia gratissima (IC50 = 0.122 mg/mL), Verbena carolina (IC50 = 0.112 mg/mL), Bouchea prismatica (IC50 = 0.122 mg/mL), Verbena menthiflora (IC50 = 0.071mg/mL) and Priva mexicana (IC50 = 0.032 mg/mL) exhibited the strongest inhibitory activities against αglucosidase. Conclusion: All the Verbenaceae species studied possess α-glucosidase inhibitory effect, with P. mexicana being the one with the strongest activity. These findings demonstrate the highs potential of these species as a source of natural antihyperglycemic agents for type 2 diabetes therapy.

Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review

“…The inhibitory activity of L. camara leaves against αglucosidase and α-amylase was evaluated using enzymatic protocols. The ethanolic extract showed a moderate α-glucosidase inhibition activity (IC50 = 0.428 mg/mL) and a low inhibitory effect on αamylase (Ávila-Reyes et al, 2019).…”