α-Glucosidase enzyme inhibitory effects and ursolic and oleanolic acid contents of fourteen Anatolian Salvia species

Kalaycıoğlu, Zeynep; Uzaşçı, Sesil; Dırmencı, Tuncay; Erim, F. Bedia

doi:10.1016/j.jpba.2018.04.014

Cited by 33 publications

(14 citation statements)

References 13 publications

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“…Moreover, a strong negative correlation was reported for both ursolic and oleanolic acid with IC50 results of r = −0.623 and r = −0.695, respectively. Based on the collective findings, the authors concluded that α-glucosidase inhibitory activity could be attributed to the presence of both triterpenoids, suggesting their potential use as antidiabetic agents [35].…”

Section: Resultsmentioning

confidence: 99%

Bioactive Components of Salvia and Their Potential Antidiabetic Properties: A Review

Rashed

Rathi

2021

Molecules

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The utilization of therapeutic plants is expanding around the globe, coupled with the tremendous expansion of alternative medicine and growing demand in health treatment. Plants are applied in pharmaceuticals to preserve and expand health—physically, mentally and as well as to treat particular health conditions and afflictions. There are more than 600 families of plants identified so far. Among the plants that are often studied for their health benefit include the genus of Salvia in the mint family, Lamiaceae. This review aims to determine the bioactive components of Salvia and their potential as antidiabetic agents. The search was conducted using three databases (PubMed, EMBASE and Scopus), and all relevant articles that are freely available in the English language were extracted within 10 years (2011–2021). Salvia spp. comprises many biologically active components that can be divided into monoterpenes, diterpenes, triterpenes, and phenolic components, but only a few of these have been studied in-depth for their health benefit claims. The most commonly studied bioactive component was salvianolic acids. Interestingly, S. miltiorrhiza is undoubtedly the most widely studied Salvia species in terms of its effectiveness as an antidiabetic agent. In conclusion, we hope that this review stimulates more studies on bioactive components from medicinal plants, not only on their potential as antidiabetic agents but also for other possible health benefits.

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Section: Resultsmentioning

confidence: 99%

Bioactive Components of Salvia and Their Potential Antidiabetic Properties: A Review

Rashed

Rathi

2021

Molecules

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“…Salvia spp. have been reported as showing antioxidant, antimicrobial, antiinflammatory, antidiabetic, anti-HIV, anti-Alzheimer's disease, antileishmanial, antimalarial, antiprotozoal, and cytotoxicity activities [17,42], which may be also characteristic to the Salvia spp. studied by us in addition to S. officinalis.…”

Section: Polyphenolsmentioning

confidence: 99%

The phytochemical and chemotaxonomic study of Salvia spp. growing in Ukraine

2020

jabb

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Salvia officinalis is a well-studied and popular medicinal plant containing toxic thujones, rather limited phytochemical and pharmacological studies have been performed on other Salvia spp. The aim of the study was to perform phytochemical and chemotaxonomic studies of Salvia genus species (n = 16) from Ukraine to identify the most promising species for the pharmaceutical industry. The content of essential oils from the leaves of 16 Salvia spp. has been studied by gas chromatography/mass spectrometry (MS) and polyphenols by high performance liquid chromatography/MS, and a chemotaxonomic study has been performed by calculation of coefficients of occurrence, originality, and pair affinity. The Salvia spp. is characterized by the presence of monoterpenoids, hydroxycinnamic acids -derivatives of caffeic acid, and flavonoids -derivatives of luteolin and apigenin. The highest content of essential oil is observed in the leaves of S. officinalis, S. grandiflora, and S. scabiosifolia (1.41%-1.85%). The highest amount of hydroxycinnamic acids is in the leaves of S. pratensis, S. illuminata, S. austriaca, and S. verticillata; the highest content of flavonoids and phenolic compounds is found in the leaves of S. grandiflora, S. pratensis, S. illuminata, S. nemorosa, S. pendula, S. sylvestris, S. nutans, S. verticillata, and S. cernua. The chemical profile of the genus has been determined; it is characterized by terpenoids such as α-and β-pinene, camphane derivatives (camphene, camphor, and borneol), p-cymene, 1,8-cineol, limonene, phenolic compounds (caffeic and rosmarinic acids), and flavonoids (cynaroside, cosmosiin, hispidulin, and cirsimaritin). A rather high concentration of toxic _-and _-thujone is typical only in the essential oil of S. officinalis (33.6% and 6.5%, respectively). The most promising species for use in the pharmaceutical industry are S. grandiflora, S. cernua, S.pratensis, S. nemorosa, and S. verticillata.

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“…α-Glucosidase enzyme inhibitory activities were studied by a slightly modified method of Shai et al (Shai et al 2011, Kalaycıoğlu et al 2018. Here 50 μL of pH 6.8 phosphate buffer, 10 μL α-Glucosidase (0.5 U/mL in phosphate buffer) and 20 μL of diluted honey samples (10, 25, 50, 100 μg/mL) were preincubated for 15 min at 37 oC.…”

Section: Antioxidant and Antidiabetic Activitymentioning

confidence: 99%

Analysis of a Rare Honey Sample From Tuzluca/Iğdır Region

Kaygusuz

2020

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Turkey has a wide variety of honey products and most of the honeys are endemic. There are many endemic honey samples in Anatolia that have not been investigated yet. Since natural honey has special benefits due to its many bioactive ingredients, it is still a challenge to classify and characterize different honey samples. In this study, an endemic and rare honey sample from the mountainous and almost uninhabited region of Tuzluca, Iğdır is reported. Honey sample is characterized by the means of antioxidant and antidiabetic capacities, nitrite and nitrate content, fructose/glucose ratio. Results indicate that the reported honey sample has unique characteristics.

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α-Glucosidase enzyme inhibitory effects and ursolic and oleanolic acid contents of fourteen Anatolian Salvia species

Cited by 33 publications

References 13 publications

Bioactive Components of Salvia and Their Potential Antidiabetic Properties: A Review

Bioactive Components of Salvia and Their Potential Antidiabetic Properties: A Review

The phytochemical and chemotaxonomic study of Salvia spp. growing in Ukraine

Analysis of a Rare Honey Sample From Tuzluca/Iğdır Region

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