α-Glucosidase inhibition of natural curcuminoids and curcumin analogs

Potent Natural Inhibitors of Alpha-Glucosidase and Alpha-Amylase against Hyperglycemia <em>in Vitro </em>and <em>in Vivo</em>

“…[42] Natural curcuminoids and curcumin analogs exert the inhibition of alpha-glucosidase [43] and further demonstrates that the alpha-glucosidase (0.4 μg/mL) and alpha-amylase (0.4 μg/mL) inhibitory potential of turmeric ethyl acetate extract is significantly higher than those of the reference drug acarbose (17.1 μg/mL and 290.6 μg/mL, respectively). In Table 4 of the present study also showed that curcumin can reduce blood Moreover, previous report also showed that oral administration at 100 mg/kg of Rutin for 45 days can help to decrease fasting plasma glucose and increase insulin levels of streptozotocin (STZ)-induced diabetic rats.…”

Cinnamic Acid Derivatives as α-Glucosidase Inhibitor Agents

“…The results showed that the natural compound bisdemethoxycurcumin showed the remarkable effect of inhibition with IC 50 of 23.0 mM [24]. Kinetic studies for the above study showed that α-glucosidase inhibitory mechanism against bisdemethoxycurcumin compound was non-competitive.…”

“…Synthesis of the active α-glucosidase inhibitor compounds contained in the methanol extract of leaves of Hyssopus officinalis, which are (7S, 8S) -syringoyl glycerol-9-O-(6-O-cinnamoyl) -β-D-glucopyranoside (24) and (7S, 8S) -syringoyl glycerol 9-O-β-Dglucopyranoside (25) compounds, was carried out as in Fig. 14 [26].…”

Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present inAzadirachta indica(neem) useful for the treatment of diabetes

“…Flavonoids isolated from the roots of Sophora flavescens showed a noncompetitive type of inhibition for α-glucosidases 33 . It was reported that natural circuminoid (bisdemethoxycurcumin) inhibited α-glucosidase in a noncompetitive fashion 34 . Inhibitors from plant sources like mangiferin with xanthinone aglycon and salacinol or kotalanol with thiosugar moieties have received attention for the development of antidiabetic drug 30 .…”