α-Glucosidase inhibitor produced by an endophytic fungus, Xylariaceae sp. QGS 01 from Quercus gilva Blume

Indrianingsih, Anastasia Wheni; Tachibana, Sanro

doi:10.1016/j.fshw.2017.05.001

Cited by 60 publications

(21 citation statements)

References 30 publications

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“…Two unsaturated fatty acids; linoleic acid (C18:2) and α-linolenic acid (C18:3) as well as two saturated ones; stearic acid (C18:0) and palmitic acid (C16:0) in addition to its glyceryl ester, 1-monopalmitin were identified by the multivariate model as α-glucosidase inhibitors. The α-glucosidase inhibitory activity of the free fatty acids has been proposed previously by similar metabolomics studies [5] and has also been verified by an in vitro enzymatic assay in other studies [31][32][33][34][35]. Investigation of the docking results showed that the carboxylic group of the fatty acids forms 1 to 3 hydrogen bonds.…”

Section: Discussionsupporting

confidence: 69%

Investigation of α-Glucosidase Inhibitory Metabolites from Tetracera scandens Leaves by GC–MS Metabolite Profiling and Docking Studies

et al. 2020

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Stone leaf (Tetracera scandens) is a Southeast Asian medicinal plant that has been traditionally used for the management of diabetes mellitus. The underlying mechanisms of the antidiabetic activity have not been fully explored yet. Hence, this study aimed to evaluate the α-glucosidase inhibitory potential of the hydromethanolic extracts of T. scandens leaves and to characterize the metabolites responsible for such activity through gas chromatography–mass spectrometry (GC–MS) metabolomics. Crude hydromethanolic extracts of different strengths were prepared and in vitro assayed for α-glucosidase inhibition. GC–MS analysis was further carried out and the mass spectral data were correlated to the corresponding α-glucosidase inhibitory IC50 values via an orthogonal partial least squares (OPLS) model. The 100%, 80%, 60% and 40% methanol extracts displayed potent α-glucosidase inhibitory potentials. Moreover, the established model identified 16 metabolites to be responsible for the α-glucosidase inhibitory activity of T. scandens. The putative α-glucosidase inhibitory metabolites showed moderate to high affinities (binding energies of −5.9 to −9.8 kcal/mol) upon docking into the active site of Saccharomyces cerevisiae isomaltase. To sum up, an OPLS model was developed as a rapid method to characterize the α-glucosidase inhibitory metabolites existing in the hydromethanolic extracts of T. scandens leaves based on GC–MS metabolite profiling.

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Section: Discussionsupporting

confidence: 69%

Investigation of α-Glucosidase Inhibitory Metabolites from Tetracera scandens Leaves by GC–MS Metabolite Profiling and Docking Studies

et al. 2020

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“…Also, a handful of the identified compounds were either fatty acids or their derivatives. This is noteworthy because previous reports have documented the in vitro antidiabetic activities of palmitic acid, oleic acid, and stearic acid found in T. triandra (Collado‐González et al, 2017; Indrianingsih & Tachibana, 2017; Liu, Deseo, Morris, Winter, & Leach, 2011). Thus, the antidiabetic activity displayed may be ascribed to these compounds.…”

Section: Discussionmentioning

confidence: 72%

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

2020

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The antidiabetic properties of Tiliacora triandra ethanol extract in diabetic rats induced with high‐fat diet (HFD)/streptozotocin (STZ) was investigated. Rats were fed with HFD for 4 weeks to induced insulin resistance, and thereafter administered with 35 mg/kg of STZ to induce diabetes. Diabetic rats received 100 and 400 mg/kg of T. triandra daily for 30 days. The body weight, blood glucose level, food and fluid intake were monitored. Furthermore, biochemical and histological assessment was performed to evaluate the hypoglycemic effect of the extract in the treated rats. T. triandra significantly decreased the blood glucose level, increased the body weight and insulin secretion. Furthermore, T. triandra attenuated hyperlipidemia, improved liver and kidney functions of treated diabetic rats. Thus, T. triandra could effectively attenuate diabetes and it complications. Practical applications Tiliacora triandra is a common vegetable consumed in Thailand and Laos. It is traditionally employed in the treatment of fever, cancer, malaria, and diabetes. The extract from the aerial part was investigated for its antidiabetic properties. The results obtained provides important pharmacological information that supports the use of T. triandra in management of diabetes.

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“…Compound 103 which was separated from Xylariaceae sp. isolated from Quercus gilva stem, possessed α-glucosidase inhibitory potential with IC 50 41.75 µg/mL, compared to quercetin (IC 50 4.80 µg/mL)[102]. The in vitro glucose consumption assay of 78 and 79 (Conc.…”

mentioning

confidence: 99%

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

et al. 2020

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Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019. Overall, 307 metabolites and more than 120 references are conferred. This is the first review on these multi-facetted metabolites from endophytic fungi.

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α-Glucosidase inhibitor produced by an endophytic fungus, Xylariaceae sp. QGS 01 from Quercus gilva Blume

Cited by 60 publications

References 30 publications

Investigation of α-Glucosidase Inhibitory Metabolites from Tetracera scandens Leaves by GC–MS Metabolite Profiling and Docking Studies

Investigation of α-Glucosidase Inhibitory Metabolites from Tetracera scandens Leaves by GC–MS Metabolite Profiling and Docking Studies

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

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