α-Glucosidase Inhibitors from a <i>Xylaria feejeensis</i> Associated with <i>Hintonia latiflora</i>

Rivera‐Chávez, José; Figueroa, Mario; González, Marı́a del Carmen; Glenn, Anthony E.; Mata, Rachel

doi:10.1021/np500897y

Cited by 51 publications

(40 citation statements)

References 24 publications

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“…Antimicrobial metabolites like colletotric acid (Zou et al 2000), griseofulvin (Park et al 2005) and glucosidase inhibitor 3S, 4R-(? )-4-hydroxymellein (Rivera-Chavez et al 2015) were reported from endophytic fungi. Endophytic fungi are ubiquitous as well as extremely diverse in plants.…”

Section: Introductionmentioning

confidence: 99%

Endophytic fungal assemblage in Achyranthes aspera Linn. revealed by internal transcribed spacer region of nuclear ribosomal RNA genes

John

Mathew

2017

3 Biotech

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Only scanty reports are available on endophytic fungal associations in Achyranthes aspera Linn. Hence in this study a total of 504 isolates belonging to ten different species of fungi were isolated from asymptomatic, surface sterilised segments of leaf, stem and root of A. aspera collected from different locations of Kerala, India. Among the isolates ascomycetes were most prevalent. Colonisation rate of fungal endophytes was high in leaf tissue (95%) followed by stem (77.75%) and root segments (33.33%). The most frequent and dominant coloniser of the host plant were Colletotrichum sp., which was isolated from all locations. Scanning electron microscopy demonstrated the presence of hyphae in the intra and intercellular spaces of the plant tissue. Morphological and phylogenetic analyses using internal transcribed spacer (ITS) sequences of nuclear rRNA genes showed that the fungi recovered belonged to the lineages of Sordariomycetes, Dothideomycetes, Eurotiomycetes and Tremellomycetes. A maximum likelihood tree revealed the relationship between the obtained sequence data and the closest sequences retrieved from the GenBank.

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Section: Introductionmentioning

confidence: 99%

Endophytic fungal assemblage in Achyranthes aspera Linn. revealed by internal transcribed spacer region of nuclear ribosomal RNA genes

John

Mathew

2017

3 Biotech

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“…During our investigations, we isolated two new compounds, pestalotin 4′-O-methyl-β-mannopyranoside (13) and 3S,4R-(+)-4-hydroxymellein (14), from an organic extract of a solid medium culture (rice). In addition, the known compounds 3S,4S-(+)-4-hydroxymellein (15), 3S-(+)-8-methoxymellein (16), coriloxine (17), and the quinone derivatives 18 and 19 were obtained [22] (▶ Fig. 3).…”

Section: Fungal Endophytes From Hintonia Latifloramentioning

confidence: 97%

Insights in Fungal Bioprospecting in Mexico

et al. 2018

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Fungi have consistently been one of the richest sources of natural products, with unprecedented chemical scaffolds and potent biological activities. During the last 20 years, pharmacognosy researchers in Mexico, in collaboration with mycologists, have discovered many novel bioactive fungi natural products and new fungal species. To date, more than 100 bioactive secondary metabolites from 20 fungi from different ecosystems throughout Mexico have been documented in peer-reviewed literature according to Scopus and SciFinder databases. These include compounds from different biosynthetic origins and structural cores with the potential for the development of anticancer, antidiabetic, and/or pesticide agents.

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“…The TD-SCF with the default solvent model was used to perform the ECD calculations of the major conformers in MeOH solution at the B3LYP/6-31G* (d) level of theory. The calculated excitation energy (nm) and rotatory strength (R) in dipole velocity (R vel ) form were simulated into an ECD curve using the Harada-Nakanishi equation (Equation (1)) as implemented in the SpecDis software [63][64][65]. All calculations were performed on the HP Cluster Platform 3000SL "Miztli.…”

Section: Computational Detailsmentioning

confidence: 99%

Structural Elucidation of Malonylcommunol and 6β-Hydroxy-trans-communic Acid, Two Undescribed Diterpenes from Salvia cinnabarina. First Examples of Labdane Diterpenoids from a Mexican Salvia Species

et al. 2020

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The aerial parts of Salvia cinnabarina afforded two undescribed labdane diterpenoids 1 and 2 (malonylcommunol and 6β-hydroxy-trans-communic acid) along with two known labdane diterpenoids, trans-communic acid (3) and trans-communol (4). Additionally, seven known metabolites were also isolated; two isopimarane diterpenoids 5 and 6, two sesquiterpenoids identified as β-eudesmol (7) and cryptomeridiol (8), and three aromatic compounds identified as phthalic acid (9), a mixture of tyrosol fatty acid esters (10) and the flavone salvigenine (11). While compounds compounds 1-3 showed significant inhibition of yeast α-glucosidase, compounds 2, 3 and 7 had no anti-inflammatory activity in the edema model induced by TPA. This paper is not only the first report on a wild population of Salvia cinnabarina, but also of the presence of labdane-type diterpenoids in a Mexican Salvia sp.Molecules 2020, 25, 1808 2 of 17 spectroscopic and X-ray diffraction analysis [7,8]. Compound 12 has been tested in several in vitro and in vivo models and exhibits a wide array of biological activities, such as antispasmodic in the isolated guinea-pig ileum model, inhibition of urinary bladder contractility in rats [9] and intestinal motility in mice [10]. Hypotensive activity in a rat model [11], along with anxiolytic and anti-depressive effects in the elevated plus-maze and the forced swimming tests in mice have also been described [12]. Compound 12 showed antimutagenic activity in the Ames test on Salmonella typhimurium and Escherichia coli [13] and also had an anticlastogenic effect in human lymphocytes of its sodium salt [14]. It should be noted that, up to now, all the studies on S. cinnabarina, have been carried out solely on cultivated material from different Botanical Gardens.Continuing with our systematic study of the genus Salvia in Mexico, and ongoing investigation for biological activity diterpenes of chemosystematic importance [15], we report herein the first study on a wild population of S. cinnabarina collected in the State of Puebla (Mexico). Several diterpenoids of the labdane (1-4) and isopimarane (5-6) skeletons were isolated, as well as two eudesmane-type sesquiterpenoids (7-8), phtalic acid (9), tyrosol derivatives (10) and the flavone salvigenin (11). Compounds 1-2 proved to be undescribed labdane-type diterpenoids related to trans-communic acid (3) and trans-communol (4), also isolated from this plant, and their structures were established as malonylcommunol (1) and 6β-hydroxy-trans-communic acid (2). While compounds 1-3 showed significant inhibition of yeast α-glucosidase, compounds 2,3 and 7 showed no anti-inflammatory activity in the edema model induced by TPA. Results and DiscussionThe aerial parts of Salvia cinnabarina afforded 11 compounds (Figure 1) after extensive chromatographic separation and purification.Molecules 2020, 25, x FOR PEER REVIEW 2 of 17

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α-Glucosidase Inhibitors from a Xylaria feejeensis Associated with Hintonia latiflora

Cited by 51 publications

References 24 publications

Endophytic fungal assemblage in Achyranthes aspera Linn. revealed by internal transcribed spacer region of nuclear ribosomal RNA genes

Endophytic fungal assemblage in Achyranthes aspera Linn. revealed by internal transcribed spacer region of nuclear ribosomal RNA genes

Insights in Fungal Bioprospecting in Mexico

Structural Elucidation of Malonylcommunol and 6β-Hydroxy-trans-communic Acid, Two Undescribed Diterpenes from Salvia cinnabarina. First Examples of Labdane Diterpenoids from a Mexican Salvia Species

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