α-Glucosidase Inhibitory Activity of Polyphenols from the Burs of Castanea mollissima Blume

Zhang, Jianwei; Zhao, Shan; Yin, Peng; Yan, Linlin; Jin, Han; Shi, Lingling; Zhou, Xiaojing; Ma, Chao

doi:10.3390/molecules19068373

Cited by 55 publications

(38 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…exhibited apparent dose-dependent inhibition on yeast a-glucosidase similar to previously reported by Ma [29] and the results were shown in Supporting Information data. Furthermore, compounds 3 and 11 have comparable activity and both were considered potent a-glucosidase inhibitors with twofold less active than the standard drug acarbose which exhibited an IC 50 value of 6.54 AE 0.04 lM.…”

Section: Resultssupporting

confidence: 88%

Superbanone, A New 2‐Aryl‐3‐benzofuranone and Other Bioactive Constituents from the Tube Roots of Butea superba

Boonsombat

Prachyawarakorn

Pansanit

et al. 2017

Chemistry & Biodiversity

View full text Add to dashboard Cite

Phytochemical investigation from the tube roots of Butea superba, led to the isolation and identification of a new 2-aryl-3-benzofuranone named superbanone (1), one benzoin, 2-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-2-(4-methoxyphenyl)ethanone (2), eight pterocarpans (3 - 10), and eleven isoflavonoids (11 - 21). Compound 2 was identified for the first time as a natural product. The structure of the isolated compounds was elucidated using spectroscopic methods, mainly 1D- and 2D-NMR. The isolated compounds and their derivatives were evaluated for α-glucosidase inhibitory and antimalarial activities. Compounds 3, 7, 8, and 11 showed promising α-glucosidase inhibitory activity (IC = 13.71 ± 0.54, 23.54 ± 0.75, 28.83 ± 1.02, and 12.35 ± 0.36 μm, respectively). Compounds 3 and 11 were twofold less active than the standard drug acarbose (IC = 6.54 ± 0.04 μm). None of the tested compounds was found to be active against Plasmodium falciparum strain 94. On the basis of biological activity results, structure-activity relationships are discussed.

show abstract

Section: Resultssupporting

confidence: 88%

Superbanone, A New 2‐Aryl‐3‐benzofuranone and Other Bioactive Constituents from the Tube Roots of Butea superba

Boonsombat

Prachyawarakorn

Pansanit

et al. 2017

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…However, acarbose has been used as a positive control for modest inhibition against the yeast AG enzyme activity in several cases. Of note, there are independent reports demonstrating that acarbose exhibited 50% inhibition of yeast enzyme activity at the concentration of 177.47 ± 6.28 µg/mL [70] and 200 µg/mL [71]. Therefore, apart from the inherent difference in inhibitor's affinity toward different AG enzymes, other conditions in assays could also cause inconsistency of inhibitors' potency.…”

Section: Analyses Of Agi Activities In Plantsmentioning

confidence: 99%

Alpha Glucosidase Inhibitory Activities of Plants with Focus on Common Vegetables

Assefa

Yang

Chae

et al. 2019

Plants

122

View full text Add to dashboard Cite

Type-2 diabetes mellitus is one of the most prevalent metabolic diseases in the world, and is characterized by hyperglycemia (i.e., high levels of glucose in the blood). Alpha-glucosidases are enzymes in the digestive tract that hydrolyze carbohydrates into glucose. One strategy that has been developed to treat type-2 diabetes is inhibition of the activity of alpha-glucosidases using synthetic drugs. However, these inhibitors are usually associated with gastrointestinal side effects. Therefore, the development of inhibitors from natural products offers an alternative option for the control of hyperglycemia. In recent years, various studies have been conducted to identify alpha-glucosidases inhibitors from natural sources such as plants, and many candidates have transpired to be secondary metabolites including alkaloids, flavonoids, phenols, and terpenoids. In this review, we focus on the alpha-glucosidases inhibitors found in common vegetable crops and the major classes of phytochemicals responsible for the inhibitory activity, and also as potential/natural drug candidates for the treatment of type-2 diabetes mellitus. In addition, possible breeding strategies for production of improved vegetable crops with higher content of the inhibitors are also described.Plants 2020, 9, 2 2 of 17 potential α-glucosidase inhibitors (AGIs) have been extensively screened or studied and acarbose, miglitol, voglibose, and 1-deoxynojirimycin (DNJ) are currently commercialized anti-glucosidase drugs (Figure 1; [7]) against type-2 diabetes, a chronic condition in which the body becomes resistant to the normal effects of insulin, resulting in ineffectiveness at managing the blood glucose levels.

show abstract

“…Yeast α-glucosidase enzyme inhibition assays using p-Nitrophenyl-α-d-glucopyranoside (p-PNP) as substrate were carried out on 96-well microplates in accordance with the method described by Zhang et al ,with minor modifications [18] . Briefly, the reaction mixture contains:α-glucosidase (15 µL, 1.0 unit/mL in 100 mM phosphate buffer, pH 6.8) mixed with different concentrations of BBG (7mg/mL -0.219 mg/mL) and 40 µl of phosphate buffer in a 96-well plate.…”

Section: In-vitro Yeast α-Glucosidase Inhibition Assaymentioning

confidence: 99%

Antioxidant, anti-cholinesterase, anti-α-glucosidase and prebiotic properties of beta-glucan extracted from Algerian barley

Mebrek¹,

Djeghim²,

Mehdi

et al. 2018

ijpm

View full text Add to dashboard Cite

Beta-glucan, such as barley-derived beta-glucan (BBG), are homopolysaccharides that have attracted attention by their nutritional and therapeutic properties. The aim of this study was to evaluate the antioxidant power of BBG extracted from local Algerian variety of barley (SAIDA 183), and its acetylcholinesterase, alpha glucosidase inhibitory activity as well as its prebiotic potential by fermentation with lactic acid bacteria isolated from camel’s milk, namely lactococcuslactisssplactis (Lc.l.l) and leuconostocmesenteroidesspmesenteroides (Ln.m.m). The results revealed that BBG exhibited low activity against DPPH and ferric-reducing power (IC50 4018.61 ± 656.69 and A0.5 at 359.88 ±63.64 µg/mL respectively), in contrast to other antioxidant tests (ABTS, Beta-carotene and CUPRAC) where BBG demonstrated a moderate activity (IC50 529.91 ±26.37, IC50 161.013±13.322, A0.5 529.79 ± 48.65 µg/mL). The scavenging ability of hydroxyl radical and superoxide radical by BBG with an IC50 at 2268.38±101.57 µg/mL and IC50 345.26± 62.32 µg/mL, respectively, while enzymatic inhibition by BBG exhibited for AChE at IC50 859.164 ±64.46 μg/mL , BChE at IC50 at 725.470 ±30.95 , α-Amylase inhibitory activity at IC50 2986.785 ± 37.046 . The bacterial growth of the two strains used in this study is favorably affected by the use of BBG as the only carbon source, in comparison with glucose as a control. In light of these findings, it can be concluded that BBG have shown moderate antioxidant and enzyme inhibitory activities and can be used as a prebiotic by acting synergistically with probiotics in functional food matrices.

show abstract

α-Glucosidase Inhibitory Activity of Polyphenols from the Burs of Castanea mollissima Blume

Cited by 55 publications

References 29 publications

Superbanone, A New 2‐Aryl‐3‐benzofuranone and Other Bioactive Constituents from the Tube Roots of Butea superba

Superbanone, A New 2‐Aryl‐3‐benzofuranone and Other Bioactive Constituents from the Tube Roots of Butea superba

Alpha Glucosidase Inhibitory Activities of Plants with Focus on Common Vegetables

Antioxidant, anti-cholinesterase, anti-α-glucosidase and prebiotic properties of beta-glucan extracted from Algerian barley

Contact Info

Product

Resources

About