α-Glucosidase inhibitory prenylated anthranols from Harungana madagascariensis

Johnson, O.O.; Zhao, Ming; Gunn, Jordan; Santarsiero, BD; Zhao, Yin; Ayoola, Gloria A.; Coker, H. A. B.; Che, CT

doi:10.1055/s-0036-1596491

Cited by 3 publications

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“…The correlation of H 2 -1′′ with C-3, C-4, and C-4a indicated that the 3-hydroxy-2,2-dimethyldihydropyran ring was located at C-3 and C-4. This determination was substantiated by the HR-ESI-MS analysis and NMR signals evident for C-1′′-C-3′′ of some 3-hydroxy-2,2-dimethyldihydropyranoxanthones [33][34][35]. The detailed HMBC correlations that are summarized in ▶ Fig.…”

Section: Resultsmentioning

confidence: 71%

Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata

Zhang

et al. 2019

Planta Med

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Six new prenylated xanthones (1–6) and seventeen known xanthones were isolated from extracts of Garcinia bracteata leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The inhibitory activities of the isolates were assayed on HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines. Compounds 1 and 15–17 showed moderate inhibitory effects on tumor cell growth, with IC50s ranging from 3.7 to 14.7 µM.

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Section: Resultsmentioning

confidence: 71%

Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata

Zhang

et al. 2019

Planta Med

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“…Alpha-glucosidases are generally categorized as hydrolytic enzymes (class 3) and mainly hydrolyze disaccharides, oligosaccharides, aromatic glycosides, sucrose and polysaccharides ( Mohamed Sham Shihabudeen, Hansi Priscilla & Thirumurugan, 2011 ; Verastegui-Omaña et al, 2017 ). In addition, alpha-glucosidase mediates transglycosidation ( Johnson et al, 2016 ). The enzyme converts the alpha-1,4-glucosidic bond in polysaccharides into an alpha-1,6-glycosidic bond or other forms of linkage ( Benayad et al, 2016 ), resulting in the formation of non-fermentable isomaltooligosaccharides (IMOs) or sugar esters/glycopeptides ( Kaneko et al, 1995 ).…”

Section: Introductionmentioning

confidence: 99%

Starch biotransformation into isomaltooligosaccharides using thermostable alpha-glucosidase from Geobacillus stearothermophilus

Chen

Wang

et al. 2018

PeerJ

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The present study first identified the biotransformation of starch as a novel preparation method was investigated using the alpha-transglucosidase-producing Geobacillus stearothermophilus U2. Subsequently, 5 L- and 20 L-scale fermentations were performed. After isolation and purification, liquid alpha-glucosidase preparations were obtained. Through covalent cross-linking and adsorption cross-linking using chitosan as the carrier and glutaraldehyde as the crosslinking agent, the conditions for immobilization of alpha-glucosidase on chitosan were determined. Moreover, Isomaltooligosaccharides (IMOs) were then prepared using chitosan membrane-immobilized alpha-glucosidase, beta-amylase, pullulanase, fungal alpha-amylase and starch as substrate. The mixed syrup that contained IMOs was evaluated and analyzed by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC). In addition, small-scale preparation of IMOs was performed. These results are a strong indication that the alpha-transglucosidase-producing G. stearothermophilus as a potential application technique can be successfully used to prepare industrial IMOs.

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“…Alpha-glucosidases are generally categorized as hydrolytic enzymes (class 3) and mainly hydrolyze disaccharides, oligosaccharides, aromatic glycosides, sucrose and polysaccharides (Mohamed Sham Shihabudeen et al, 2011;Madariaga-Mazon et al, 2016). In addition, alphaglucosidase mediates transglycosidation (Johnson et al, 2016). The enzyme converts the alpha-1,4glucosidic bond in polysaccharides into an alpha-1,6-glycosidic bond or other forms of linkage (Benayad et al, 2016), resulting in the formation of non-fermentable isomaltooligosaccharides (IMOs) or sugar esters/glycopeptides (Kaneko et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Peer Review #1 of "Starch biotransformation into isomaltooligosaccharides using thermostable alpha-glucosidase from Geobacillus stearothermophilus (v0.2)"

2018

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The present study first identified the biotransformation of starch as a novel preparation method was investigated using the alpha-transglucosidase-producing Geobacillus stearothermophilus (G. stearothermophilus) U2. Subsequently, 5 L-and 20 L-scale fermentations were performed. After isolation and purification, liquid alpha-glucosidase preparations were obtained. Through covalent cross-linking and adsorption cross-linking using chitosan as the carrier and glutaraldehyde as the crosslinking agent, the conditions for immobilization of alpha-glucosidase on chitosan were determined. Moreover, Isomaltooligosaccharides (IMOs) were then prepared using chitosan membraneimmobilized alpha-glucosidase, beta-amylase, pullulanase, fungal alpha-amylase and starch as substrate. The mixed syrup that contained IMOs was evaluated and analyzed by thin-layer chromatography and high-performance liquid chromatography (HPLC). In addition, small-scale preparation of IMOs was performed. These results are a strong indication that the alpha-transglucosidase-producing G. stearothermophilus as a potential application technique can be successfully used to prepare industrial IMOs.PeerJ reviewing PDF |

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α-Glucosidase inhibitory prenylated anthranols from Harungana madagascariensis

Cited by 3 publications

References 0 publications

Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata

Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata

Starch biotransformation into isomaltooligosaccharides using thermostable alpha-glucosidase from Geobacillus stearothermophilus

Peer Review #1 of "Starch biotransformation into isomaltooligosaccharides using thermostable alpha-glucosidase from Geobacillus stearothermophilus (v0.2)"

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