α Glutathione S-transferase: a potential marker of ischemia-reperfusion injury of the intestine after cardiac surgery?

McMonagle, Morgan; Halpenny, M.; McCarthy, A.; Mortell, Alan; Manning, Fiona; Kilty, Cormac G.; Mannion, D.; Wood, A. E.; Corbally, Martin

doi:10.1016/j.jpedsurg.2006.05.017

Cited by 11 publications

(9 citation statements)

References 30 publications

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“…An important consequence may be translocation of toxins and microbial flora directly into the bloodstream and the development of necrotizing enterocolitis (34,35). In our institution as well as in others, gastrointestinal complications ranging from nonspecific feeding intolerance to catastrophic necrotizing enterocolitis contribute significantly to overall morbidity, length of stay, and mortality in the single-ventricle population (36,37). Gastric tonometry has previously been validated as a means to monitor organ specific perfusion status.…”

Section: Discussionmentioning

confidence: 96%

Correlation of abdominal site near-infrared spectroscopy with gastric tonometry in infants following surgery for congenital heart disease*

Kaufman

Almodovar

Zuk

et al. 2008

Pediatric Critical Care Medicine

134

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Abdominal site rSO2, measured in infants with either single or biventricular physiology, exhibits a strong correlation with gastric pHi as well as with serum lactate and SVO2. The results indicate that rSO2 measurements over the anterior abdominal wall correlate more strongly than flank rSO2 with regard to systemic indices of oxygenation and perfusion. This study suggests that the NIRS monitor is a valid modality to obtain an easy, immediate, and noninvasive measurement of splanchnic rSO2 in infants following cardiac surgery for congenital heart disease.

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Section: Discussionmentioning

confidence: 96%

Correlation of abdominal site near-infrared spectroscopy with gastric tonometry in infants following surgery for congenital heart disease*

Kaufman

Almodovar

Zuk

et al. 2008

Pediatric Critical Care Medicine

134

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“…The glutathione s-transferases (GSTs) are involved in cell protection, antioxidation and detoxification of a range of toxic and foreign compounds within the cell by conjugating them to glutathione. αGST is predominantly present in liver, kidney and intestine and has been proposed as a potential marker for, amongst others, intestinal epithelial cell damage [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Glutathione Transferase as a Potential Marker for Gut Epithelial Injury versus the Protective Role of Breast Milk sIgA in Infants with Rota Virus Gastroenteritis

Sherif

Raouf²,

Rifay

et al. 2015

Open Access Maced J Med Sci

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BACKGROUND:Secretory immunoglobulin A (SIgA) plays an important protective role in the recognition and clearance of enteric pathogens.AIM:This study was designed to assess if mucosal integrity “measured by secretory IgA (SIgA)” is a protective factor from more epithelial alteration “measured by glutathione transferase” in infants with Rota gastroenteritis and its relation to infants’ feeding pattern.PATIENTS AND METHODS:This study was conducted on 79 infants aged 6 months and less from those diagnosed as having gastroenteritis and admitted to Gastroenteritis Department in Abo El Rish Pediatric Hospital, Cairo University. Plasma glutathione s-transferases and Stool SIgA were measured using ELISA technique. Rota virus detection was done by Reverse transcriptase PCR.RESULTS:SIgA was found to be significantly positive in exclusive breast fed infants, Glutathione transferase was significantly more frequently positive in Rota positive cases than Rota negative cases by Reverse transcriptase PCR. A significant negative correlation between Glutathione transferase and Secretory IgA was found, (p < 0.05).CONCLUSION:Breast feeding should be encouraged and highly recommended in the first two years of life as it provides Secretory IgA to breast fed infants who in turn protect them against epithelial damage caused by Rota viral gastroenteritis.

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“…However, these "old" markers are used less and less because their accuracy is subject to debate. Although other molecules (such as αGST and D-dimer) have been suggested as alternatives to D-lactate and leukocytes, their value has yet to be established; this has prompted a search for other candidates [13][14]21] . As shown in clinical studies, PCT is a promising biomarker for the diagnosis of intestinal ischemia.…”

Section: Need For New Biomarkersmentioning

confidence: 99%

“…With a view to improving the preoperative diagnosis, some researchers have suggested measuring several biomarkers: L and D-lactate [9][10][11] , leukocytes [11,12] , α glutathione S-transferase (αGST) [12][13][14] , diamine oxidase [15] , trehalase [16] , alcohol dehydrogenase [17] ), intestinal fatty acid binding protein [18][19][20] , and D-dimer [21] . Whilst most of these markers prove to be accurate in preclinical studies, their use in clinical practice has been limited by several shortcomings (lack of sensitivity and specificity; poor assay reproducibility and the presence of species-specific metabolites).…”

Section: Introductionmentioning

confidence: 99%

Procalcitonin and intestinal ischemia: A review of the literature

Cossé¹,

Sabbagh²,

Kamel³

et al. 2014

WJG

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Intestinal ischemia is common after emergency gastrointestinal or cardiovascular surgery. At present, there are no diagnostic tools for the early diagnosis of intestinal ischemia. In the last decade, procalcitonin (PCT) has been suggested as a marker of this condition. Here, we review the use of PCT as a diagnostic tool for intestinal ischemia. Two reviewers independently searched the PubMed and EMBASE databases for articles on intestinal ischemia and PCT. They then considered (1) the criteria applicable to preclinical and clinical data; and (2) PCT's predictive value in the diagnosis of intestinal ischemia. Article quality was rated according to the STAndards for Reporting of Diagnostic accuracy. Between 1993 and 2014, seven studies (including two preclinical studies and five clinical studies) dealt with the use of PCT to diagnose intestinal ischemia. Procalcitonin's sensitivity, specificity, positive predictive value and negative predictive value ranged between 72% and 100%; 68% and 91%; 27% and 90% and 81% and 100%, respectively. The area under the receiver operating characteristic curve ranged from 0.77 to 0.92. In view of the preclinical and clinical data, we consider that PCT can be used in daily practice as a tool for diagnosing intestinal ischemia.© 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Procalcitonin; Intestinal; Ischemia; Diagnosis; Review Core tip: The serum procalcitonin level is clinically relevant for the diagnosis of intestinal ischemia. In the diagnosis of intestinal ischemia, procalcitonin's sensitivity is greater than 70% and its negative predictive value is greater than 80%.

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α Glutathione S-transferase: a potential marker of ischemia-reperfusion injury of the intestine after cardiac surgery?

Cited by 11 publications

References 30 publications

Correlation of abdominal site near-infrared spectroscopy with gastric tonometry in infants following surgery for congenital heart disease*

Correlation of abdominal site near-infrared spectroscopy with gastric tonometry in infants following surgery for congenital heart disease*

Glutathione Transferase as a Potential Marker for Gut Epithelial Injury versus the Protective Role of Breast Milk sIgA in Infants with Rota Virus Gastroenteritis

Procalcitonin and intestinal ischemia: A review of the literature

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