α-Interferon and isoprinosine in adult-onset subacute sclerosing panencephalitis

Gökçil, Zeki; Odabaşı, Zeki; Demirkaya, Şeref; Eroğlu, Erdal; Vural, Okay

doi:10.1016/s0022-510x(98)00302-5

Cited by 31 publications

(15 citation statements)

References 11 publications

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“…[79][80][81] Gokcil et al, in their recent article, reviewed 53 patients who had been treated by intraventricular interferon alfa with or without oral isoprinosine; 30 (59%) of these patients showed significant stabilisation or improvement. 66 They also reported better efficacy with a combination of oral isoprinosine and intraventricular interferon alfa even in adult patients with SSPE. Cerebrospinal fluid measles antibody, and renal and hepatic functions, need to be followed up during treatment.…”

Section: Acute Fulminant Sspementioning

confidence: 97%

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Subacute sclerosing panencephalitis

Garg¹

2002

Postgraduate Medical Journal

318

167

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Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder of childhood and early adolescence. It is caused by persistent defective measles virus. Brain biopsies or postmortem histopathological examination show evidence of astrogliosis, neuronal loss, degeneration of dendrites, demyelination, neurofibrillary tangles, and infiltration of inflammatory cells. Patients usually have behavioral changes, myoclonus, dementia, visual disturbances, and pyramidal and extrapyramidal signs. The disease has a gradual progressive course leading to death within 1-3 years. The diagnosis is based upon characteristic clinical manifestations, the presence of characteristic periodic EEG discharges, and demonstration of raised antibody titre against measles in the plasma and cerebrospinal fluid. Treatment for SSPE is still undetermined. A combination of oral isoprinosine (Inosiplex) and intraventricular interferon alfa appears to be the best effective treatment. Patients responding to treatment need to receive it life long. Effective immunisation against measles is the only solution presently available to the problem of this dreaded disease.

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Section: Acute Fulminant Sspementioning

confidence: 97%

“…65 In a preliminary study, Gokcil et al observed that treatment with oral isoprinosine plus interferon alfa is effective for adult onset SSPE. 66 …”

Section: (C) Neuroimagingmentioning

confidence: 99%

Subacute sclerosing panencephalitis

Garg¹

2002

Postgraduate Medical Journal

318

167

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“…Eight cases were previously reported [8]. The diagnosis of SSPE was based on history, clinical manifestations with mental and behavioral symptoms, myoclonic jerks, typical EEG findings and positive serum or CSF measles antibody titers.…”

Section: Methodsmentioning

confidence: 99%

Long-term follow-up of patients with adult-onset subacute sclerosing panencephalitis

Eroğlu¹,

Gökçil²,

Bek³

et al. 2008

Journal of the Neurological Sciences

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“…1 Although SSPE affects mostly children younger than 12 years, interestingly, there is a considerable increase in the number of adult cases of SSPE. 2,3 Case report: A 15 Year old boy of 9 th grade, hailing from Jamalpur, admitted into DMCH (Dhaka Medical College Hospital) with the complaints of altered behavior for last 7 months and jerky movement of the whole body for same duration. Seven months back, before admission, he developed fever which was high grade continued in nature, with chills and rigor, subsided with anti pyretic.…”

Section: Introductionmentioning

confidence: 99%