α-Lipoic acid enhances endogenous peroxisome-proliferator-activated receptor-γ to ameliorate experimental autoimmune encephalomyelitis in mice

Wang, Kai-Chen; Tsai, Ching-Piao; Lee, Chao-Lin; Chen, Shao-Yuan; Lin, Gu‐Jiun; Yen, Mao‐Hsiung; Sytwu, Huey‐Kang; Chen, Shyi-Jou

doi:10.1042/cs20120560

Cited by 47 publications

(48 citation statements)

References 49 publications

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“…α(alpha)-lipoic acid (ALA) is a natural, endogenous antioxidant that acts as a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist to counteract OS (48,49). Another data provided the first evidence that ALA may increase the production of PPAR-γ in vivo in EAE and may reveal antioxidative and immunomodulatory mechanisms for the application of ALA in humans with MS (48).…”

Section: Inflammatory Mediators and Antioxidantsmentioning

confidence: 98%

“…Among enzymes, the most important include catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), SOD, serum paraoxonase, arylesterase (53), and δ-aminolevulinate dehydratase (δ-ALA-D) (48). SOD has three isoforms, namely, copper/zincSOD (SOD-1), manganeseSOD (SOD-2), and extracellular EC-SOD (58).…”

Section: Antioxidants: Enzymatic and Nonenzymaticmentioning

confidence: 99%

“…The GSTP1 polymorphism and quinone oxidoreductase 1 (NQO1) variant genotypes in MS patients suggest that a defective function of detoxification enzymes could be a determinant of susceptibility and the clinical presentation of the disease (46,47). α(alpha)-lipoic acid (ALA) is a natural, endogenous antioxidant that acts as a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist to counteract OS (48,49). Another data provided the first evidence that ALA may increase the production of PPAR-γ in vivo in EAE and may reveal antioxidative and immunomodulatory mechanisms for the application of ALA in humans with MS (48).…”

Section: Inflammatory Mediators and Antioxidantsmentioning

confidence: 99%

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Novel Approaches of Oxidative Stress Mechanisms in the Multiple Sclerosis Pathophysiology and Therapy

Adamczyk

Niedziela

Adamczyk-Sowa

2017

Multiple Sclerosis: Perspectives in Treatment and Pathogenesis

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Abstract:It is suspected that the development of multiple sclerosis (MS) can be affected by oxidative stress (OS). In the acute phase of the disease, OS is responsible for initiating inflammation, whereas in the chronic phase it sustains neurodegenerative process. Redox processes in MS are related to dysregulation of axonal bioenergetics, cerebral iron accumulation, mitochondrial dysfunction, impaired oxidant/antioxidant balance, and OS memory. This chapter gives an overview of the role of OS in MS.

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Section: Inflammatory Mediators and Antioxidantsmentioning

confidence: 98%

Section: Antioxidants: Enzymatic and Nonenzymaticmentioning

confidence: 99%

Section: Inflammatory Mediators and Antioxidantsmentioning

confidence: 99%

See 1 more Smart Citation

Novel Approaches of Oxidative Stress Mechanisms in the Multiple Sclerosis Pathophysiology and Therapy

Adamczyk

Niedziela

Adamczyk-Sowa

2017

Multiple Sclerosis: Perspectives in Treatment and Pathogenesis

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“…[62][63][64][65] The remaining preclinical studies utilized the EAE rodent model. 42,62,[66][67][68][69][70][71] Detailed information is found in Supplementary Table 5 and risk-of-bias assessments in Supplementary Figure 4(a) and (b).…”

Section: Anti-oxidant Vitaminsmentioning

confidence: 99%

“…Four studies examined the ability of purified EGCG (95%) to decrease the severity of EAE disease (Table 2 and Supplementary Table 3). [37][38][39][40] EGCG-fed animals consistently showed decreased severity scores compared to control-fed animals, which was associated with suppressed immune cell infiltrates, [37][38][39] decreased demyelination in the spinal cord, 39,42 and a decreased production of inflammatory cytokines that promote Th1 and Th17 differentiation. 37,39,40 Furthermore, EGCG enhanced the viability and outgrowth of hippocampal cells in vitro.…”

Section: Polyphenolsmentioning

confidence: 99%

Over-the-counter anti-oxidant therapies for use in multiple sclerosis: A systematic review

et al. 2015

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Background: Anti-oxidant compounds that are found in over-the-counter (OTC) supplements and foods are gaining interest as treatments for multiple sclerosis (MS). They are widely used by patients, sometimes without a clear evidence base. Objective: We conducted a systematic review of animal and clinical research to determine the evidence for the benefits of OTC anti-oxidants in MS. Methods: Using predefined criteria, we searched key databases. Two authors scrutinized all studies against inclusion/exclusion criteria, assessed study risk-of-bias and extracted results. Results: Of the 3507 titles, 145 met criteria and included compounds, α(alpha)-lipoic acid (ALA), antioxidant vitamins, Ginkgo biloba, quercetin, resveratrol and epigallocatechin-3-gallate (ECGC). The strongest evidence to support OTC anti-oxidants was for compounds EGCG and ALA in animal models; both consistently showed anti-inflammatory/anti-oxidant effects and reduced neurological impairment. Only vitamin E, Ginkgo biloba and ALA were examined for efficacy in pilot clinical trials with either conflicting evidence or evidence of no benefit. Conclusion: OTC anti-oxidants EGCG and ALA show the most consistent benefit, however only in preclinical studies. There is no evidence that they alter MS relapses or progression. Future work should focus on testing more of these therapies for clinical efficacy before recommending them to MS patients. Anti-oxidant drug therapies, diets, and supplements, purported to counteract ROS and RNS cascades, are available as over-the-counter (OTC) remedies yet their benefits have not been proven. Most people with MS reporting using an OTC supplement despite the lack of a clear evidence base. 15 We undertook this study to systematically and rigorously examine current research findings on the effects of OTC anti-oxidant supplements in animal models and clinical trials in MS. Our aim was to translate research findings to MS clinicians and to identify areas for future research. Keywords Methods Search strategyWith the assistance of a librarian expert in systematic reviews and using predefined search terms (Table 1), we searched PubMed, CINAHL, PsychInfo, the Cochrane Library, and the Central Register of Controlled Clinical Trials, including all years up to 1 October 2013 (English language only). Clinical studies were included if the participants had MS or the biological products tested were from people with MS. Animal studies were included if a disease, similar to MS, was induced in animals and included at least behavioral findings. Data extraction and synthesisFollowing Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, 16 and after duplicates were removed, we merged titles retrieved across search databases. At the title, abstract, and manuscript levels of the search, two authors evaluated inclusion status independently and if the authors disagreed, the article was included. Data extraction and synthesis was conducted on manuscripts that were categorized by compound tested. Referenc...

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Therapeutic potential of α‐lipoic acid derivative, sodium zinc histidine dithiooctanamide, in a mouse model of allergic rhinitis

Nakano

Hsu

Lai

et al. 2017

Int Forum Allergy Rhinol

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α-Lipoic acid enhances endogenous peroxisome-proliferator-activated receptor-γ to ameliorate experimental autoimmune encephalomyelitis in mice

Cited by 47 publications

References 49 publications

Novel Approaches of Oxidative Stress Mechanisms in the Multiple Sclerosis Pathophysiology and Therapy

Novel Approaches of Oxidative Stress Mechanisms in the Multiple Sclerosis Pathophysiology and Therapy

Over-the-counter anti-oxidant therapies for use in multiple sclerosis: A systematic review

Therapeutic potential of α‐lipoic acid derivative, sodium zinc histidine dithiooctanamide, in a mouse model of allergic rhinitis

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