α-Mangostin Extraction from the Native Mangosteen (Garcinia mangostana L.) and the Binding Mechanisms of α-Mangostin to HSA or TRF

Guo, Ming; Lu, Xiaowang; Wang, Hongzheng; Brodelius, Peter E.

doi:10.1371/journal.pone.0161566

Cited by 32 publications

(19 citation statements)

References 48 publications

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“…Since MIC and MBC against S. aureus and P. acnes of AMG were 3.9 μg/ml and 7.8 μg/ml, respectively, the AMG content that was selected for loading into the formulation should provide the concentration that will achieve the antibacterial activity and should be more than these critical concentrations. Because AMG is a low-polarity compound [31], its solubility in water is very low, about 0.2 μg/ml [14]. Therefore, purified water could not be used as a vehicle of AMG for this purpose.…”

Section: Resultsmentioning

confidence: 99%

Physicochemical properties of alpha-mangostin loaded nanomeulsions prepared by ultrasonication technique

Asasutjarit

Meesomboon

Adulheem

et al. 2019

Heliyon

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HypothesisAlpha-mangostin (AMG) is a natural compound possessing strong antibacterial activity. Because of its poor water solubility, the formulations of AMG usually require high concentrations of solubilizers leading limitation for using in some clinical applications. Thus, the novel formulation of topical nanoemulsion (NE) containing AMG (AMG-NE) with optimal content of the oil phase and surfactants was developed.ExperimentsAMG was extracted, purified and used as an active ingredient of AMG-NE. Blank NEs (NEs without AMG) with varying in contents of the oil phase and surfactants and AMG-NE were prepared by the ultrasonication technique. They were investigated their physicochemical properties including antibacterial activity against Staphyloccocus aureus and Propionibacterium acnes (which is recently renamed as Cutibacterium acnes).FindingsBlank NEs and AMG-NE had droplet size in a range of nanometer and negative value of zeta potential. The droplet size, polydispersity index and zeta potential of blank NEs were affected by formulation compositions and sonication intensities. AMG could be loaded into a representative Blank NE at a maximum concentration of 0.2% w/w and did not cause significant changes in physicochemical properties. AMG-NE showed the antibacterial activity against Staphyloccocus aureus and Propionibacterium acnes without toxicity to the skin cells. Therefore, AMG-NE had potential for using in a clinical study to investigate its efficacy and safety in patients.

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Section: Resultsmentioning

confidence: 99%

Physicochemical properties of alpha-mangostin loaded nanomeulsions prepared by ultrasonication technique

Asasutjarit

Meesomboon

Adulheem

et al. 2019

Heliyon

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“…This indicated the presence of polyphenol in GME. The other peaks appearing at 1638, 1440, 1279, and 1077 cm −1 represented C=O stretching of carbonyl group, aromatic C=C stretching, C-O-C stretching of methoxy group, and C-O-C stretching, respectively [27,28]. C-H stretching from methyl groups was indicated by two peaks at 2853 and 2923 cm −1 [5].…”

Section: Ftir Characteristics Ftir Analysis Was Performed Tomentioning

confidence: 97%

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Sriyanti

Edikresnha

Rahma

et al. 2017

Journal of Nanomaterials

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Nanofiber mats of polyvinyl(pyrrolidone) (PVP) with Garcinia mangostana extract (GME) as the encapsulated drug have been developed using electrospinning. SEM images of all electrospun PVP/GME composite nanofiber mats showed that they had similar and smooth morphology, no beads, and spindle shape. Its average diameter decreased and its surface area therefore increased with the decrease of its PVP concentration. The benefit of high surface area is obvious in drug delivery systems for poorly water-soluble drugs. Their FTIR spectra indicated that PVP and GME interacted intermolecularly via hydrogen bonds in the composite nanofiber mats. A conformational change in the C-H chain of PVP occurred in the composite nanofiber mats due to the intermolecular interactions. Their XRD patterns confirmed that they were amorphous because of amorphization during electrospinning. The XRD analyses also strengthened the FTIR studies; namely, GME and PVP formed intermolecular interactions in the electrospun composite nanofiber mats. As a result, GME as the encapsulated drug was molecularly dispersed in the electrospun PVP nanofiber matrix that functioned as a drug delivery system. From the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, the composite nanofiber mats exhibited very high antioxidant activities despite having been exposed to high voltage during electrospinning. Therefore, they are potential antioxidant products for food and pharmaceutics.

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“…One such fruit is the mangosteen (Garcinia mangostana L.), which belongs to the Clusiaceae (Guttiferae) family. This evergreen tree grows in the tropical forests of Southeast Asian countries including Indonesia, Malaysia, Sri Lanka, the Philippines, Cambodia, Vietnam, Thailand and China (Guo et al, 2016;Yang et al, 2017). Mangosteen trees grow to heights of 25 m, while its flowers are 4-5 cm across and are red and green (Obolskiy et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and polyphenol content in extracts from various parts of fresh and frozen mangosteen

Muzykiewicz

Zielonka-Brzezicka

Siemak

et al. 2020

Acta Sci Pol Technol Aliment

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Background. The search for new sources of natural antioxidants is very important because many diseases are caused by oxidative stress. Fruit which contain antioxidants are an important part of a healthy diet. The aim of this study was to evaluate the antioxidant activity of extracts of both the fresh and frozen peel and the flesh of Garcinia mangostana L. Materials and methods. The extracts from the fresh and frozen peel and the flesh of mangosteen were prepared by ultrasound-assisted extraction using 20%, 40%, 70% and 96% (v/v) ethanol for 15, 30 or 60 minutes. The antioxidant potential was evaluated by the DPPH, ABTS, CUPRAC, FRAP and FIC methods, whereas the total phenolic content was measured using the Folin-Ciocalteu (F-C) technique. The contents of anthocyanins and flavonoids in the peel extracts were also determined. Results. In most cases, the highest antioxidant activity was observed in the fresh peel samples. It was higher than the antioxidant potential of the frozen peels and the fresh and frozen flesh. The ultrasound-assisted extraction, in particular those lasting 30 or 60 minutes and using ethanol in concentrations higher than 20% (v/v), seemed to be an effective extraction process. Conclusion. The obtained results suggest that G. mangostana, in particular its peels, could be a valuable source of antioxidants. The extraction parameters, such as the time or solvent concentration, as well as the type of plant material, had an impact on the tested properties of the extracts. However, more detailed studies on the antioxidant activity of the studied plants are required.

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α-Mangostin Extraction from the Native Mangosteen (Garcinia mangostana L.) and the Binding Mechanisms of α-Mangostin to HSA or TRF

Cited by 32 publications

References 48 publications

Physicochemical properties of alpha-mangostin loaded nanomeulsions prepared by ultrasonication technique

Physicochemical properties of alpha-mangostin loaded nanomeulsions prepared by ultrasonication technique

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Antioxidant activity and polyphenol content in extracts from various parts of fresh and frozen mangosteen

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