α-Mangostin-induced apoptosis is mediated by estrogen receptor α in human breast cancer cells

Won, Yeong‐Seon; Lee, Ju-Hye; Kwon, Sang Hoon; Kim, Jae-Yong; Park, Ki-Hun; Lee, Mi-Kyung; Seo, Kwon‐Il

doi:10.1016/j.fct.2014.01.040

Cited by 44 publications

(20 citation statements)

References 45 publications

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“…The antioxidant, antiinflammatory, antibacterial and antiviral activities of xanthones are described [5]. The antineoplastic activity of a-mangostin (a-M; 1,3,6-trihydroxy-7-methoxy-2,8-diprenyl-9H-xanthen-9-one), the most representative xanthone in mangosteen pericarp (78% content), has been established on human hepatoma [6], breast cancer [7] and pancreatic cancer [8]. In particular a-M was reported to have antitumor effects on human melanoma tumor cells previously [9]; however, the details of the mechanism remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of cell proliferation, migration and invasion of B16-F10 melanoma cells by α-mangostin

Beninati¹,

Oliverio²,

Cordella³

et al. 2014

Biochemical and Biophysical Research Communications

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a b s t r a c tIn this study, we have evaluated the potential antineoplastic effects of a-mangostin (a-M), the most representative xanthone in Garcinia mangostana pericarp, on melanoma cell lines. This xanthone markedly inhibits the proliferation of high-metastatic B16-F10 melanoma cells. Furthermore, by deeply analyzing which steps in the metastatic process are influenced by xanthone it was observed that a-M strongly interferes with homotypic aggregation, adhesion, plasticity and invasion ability of B16-F10 cells, probably by the observed reduction of metalloproteinase-9 activity. The antiproliferative and antimetastatic properties of a-M have been established in human SK-MEL-28 and A375 melanoma cells. In order to identify pathways potentially involved in the antineoplastic properties of a-M, a comparative mass spectrometry proteomic approach was employed. These findings may improve our understanding of the molecular mechanisms underlying the anti-cancer effects of a-M on melanoma.

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Section: Introductionmentioning

confidence: 99%

Inhibition of cell proliferation, migration and invasion of B16-F10 melanoma cells by α-mangostin

Beninati¹,

Oliverio²,

Cordella³

et al. 2014

Biochemical and Biophysical Research Communications

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“…Undoubtedly, impaired ERα expression can contribute to enhancements of intrinsic/ extrinsic apoptotic signaling by widely modulating the expression of multiple apoptosis-related proteins. [31][32][33][34] However, the decrease in ERα expression caused by NDV-D90 was accompanied by increases in GPER protein expression. The GPER has been confirmed to be a tumor suppressor in ER-positive BCs.…”

Section: Discussionmentioning

confidence: 99%

NDV‐D90 inhibits 17β‐estradiol‐mediated resistance to apoptosis by differentially modulating classic and nonclassic estrogen receptors in breast cancer cells

Peng

Tang

Xie

et al. 2020

J of Cellular Biochemistry

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Newcastle disease virus (NDV) is endowed with the oncolytic ability to kill tumor cells, while rarely causing side effects in normal cells. Both estrogen receptor α (ERα) and the G protein estrogen receptor (GPER) modulate multiple biological activities in response to estrogen, including apoptosis in breast cancer (BC) cells. Here, we investigated whether NDV‐D90, a novel strain isolated from natural sources in China, promoted apoptosis by modulating the expression of ERα or the GPER in BC cells exposed to 17β‐estradiol (E2). We found that NDV‐D90 significantly killed the tumor cell lines MCF‐7 and BT549 in a time‐ and dose‐dependent manner. We also found that NDV‐D90 exerted its effects on the two cell lines mainly by inducing apoptosis but not necrosis. NDV‐D90 induced apoptosis via the intrinsic and extrinsic signaling pathways in MCF‐7 cells (ER‐positive cells) during E2 exposure not only by disrupting the E2/ERα axis and enhancing GPER expression but also by modulating the expression of several apoptosis‐related proteins through ERα‐and GPER‐independent processes. NDV‐D90 promoted apoptosis via the intrinsic signaling pathway in BT549 cells (ER‐negative cells), possibly by impairing E2‐mediated GPER expression. Furthermore, NDV‐D90 exerted its antitumor effects in vivo by inducing apoptosis. Overall, these results demonstrated that NDV‐D90 promotes apoptosis by differentially modulating the expression of ERα and the GPER in ER‐positive and negative BC cells exposed to estrogen, respectively, and can be utilized as an effective approach to treating BC.

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“…Furthermore, a study revealed that the presence of ERα is necessary for growth inhibition and apoptosis induced by α-mangostin in human breast cancer cells, as evidenced by that MDA-MB-231 cells (ER-α negative) is less sensitive to α-mangostin than MCF-7 cells (ERα positive), and that knockdown of ERα reduced the cell growth inhibition and caspase-7 activation induced by α-mangostin [ 109 ]. Besides, lymph node metastasis partly contributes to the lethality of breast cancer.…”

Section: Fruitsmentioning

confidence: 99%

Dietary Natural Products for Prevention and Treatment of Breast Cancer

et al. 2017

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Breast cancer is the most common cancer among females worldwide. Several epidemiological studies suggested the inverse correlation between the intake of vegetables and fruits and the incidence of breast cancer. Substantial experimental studies indicated that many dietary natural products could affect the development and progression of breast cancer, such as soy, pomegranate, mangosteen, citrus fruits, apple, grape, mango, cruciferous vegetables, ginger, garlic, black cumin, edible macro-fungi, and cereals. Their anti-breast cancer effects involve various mechanisms of action, such as downregulating ER-α expression and activity, inhibiting proliferation, migration, metastasis and angiogenesis of breast tumor cells, inducing apoptosis and cell cycle arrest, and sensitizing breast tumor cells to radiotherapy and chemotherapy. This review summarizes the potential role of dietary natural products and their major bioactive components in prevention and treatment of breast cancer, and special attention was paid to the mechanisms of action.

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α-Mangostin-induced apoptosis is mediated by estrogen receptor α in human breast cancer cells

Cited by 44 publications

References 45 publications

Inhibition of cell proliferation, migration and invasion of B16-F10 melanoma cells by α-mangostin

Inhibition of cell proliferation, migration and invasion of B16-F10 melanoma cells by α-mangostin

NDV‐D90 inhibits 17β‐estradiol‐mediated resistance to apoptosis by differentially modulating classic and nonclassic estrogen receptors in breast cancer cells

Dietary Natural Products for Prevention and Treatment of Breast Cancer

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