α-Melanocyte-Stimulating Hormone

Nordlund, James J.

doi:10.1001/jama.1991.03470190101039

JAMA

1991

DOI: 10.1001/jama.1991.03470190101039

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α-Melanocyte-Stimulating Hormone

James J. Nordlund¹

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Cited by 5 publications

(1 citation statement)

References 18 publications

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“…They have marked neurotrophic properties, both during development and during the recovery process following nerve injury (Zohar & Salomon, 1992;Strand et al, 1991;McCaig & Stewart, 1992). They also have potent antipyretic and antiinflammatory properties (Nordlund, 1991;Hiltz et al, 1991) antagonizing the action of cytokines such as interleukin 1, interleukin 6, and TNFa (Martin et al, 1991). a-MSH was described as a mammotrophic factor released after estrogen treatment (Ellerkmann et al, 1992).…”

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confidence: 99%

Molecular Cloning of a Mouse Melanocortin 5 Receptor Gene Widely Expressed in Peripheral Tissues

Labbé¹,

Desarnaud²,

Eggerickx³

et al. 1994

Biochemistry

199

104

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A mouse genomic clone named HGMP01B has been isolated by homology screening with a probe representing part of the human melanocortin 3 receptor gene. HGMP01B was found to encode a 325 amino acid protein with all the landmarks of G-protein-coupled receptors and belonging to the growing melanocortin receptor family. This receptor displays four potential sites for N-linked glycosylation and five potential sites of phosphorylation by protein kinase C. The HGMP01B gene was found to be expressed in many tissues, including skin, adrenal gland, skeletal muscle, bone marrow, spleen, thymus, gonads, uterus, and brain. A stable Chinese hamster ovary (CHO) cell line expressing approximately 10,000 receptors per cell was established. This cell line displayed a saturable binding capacity for the radioiodinated alpha-melanocyte-stimulating hormone (alpha-MSH) analog [Nle4,D-Phe7]-alpha-MSH (NDP-MSH) with an apparent Kd of 1.47 +/- 0.15 nM. Binding of the labeled ligand was competed for by all melanocortin peptides, except beta-endorphin or corticotropin-like intermediate lobe peptide (CLIP). NDP-MSH was the most powerful competitor, followed by alpha-MSH, adrenocorticotropic hormone (ACTH), beta-MSH, the gamma-MSHs, and ACTH 4-10. Functional assays confirmed that HGMP01B, like other melanocortin receptors, stimulated adenylyl cyclase. The potency order obtained in these cyclic adenosine monophosphate (cAMP) accumulation assays was consistent with that of the binding studies. HGMP01B therefore appears as a fifth melanocortin receptor (MC5), responding mainly to alpha-MSH (EC50 = 1.07 +/- 0.13 nM) and endowed with a pharmacological profile similar to that of the melanocyte MSH (MC1) receptor, but characterized by a broad tissue distribution.(ABSTRACT TRUNCATED AT 250 WORDS)

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mentioning

confidence: 99%

Molecular Cloning of a Mouse Melanocortin 5 Receptor Gene Widely Expressed in Peripheral Tissues

Labbé¹,

Desarnaud²,

Eggerickx³

et al. 1994

Biochemistry

199

104

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Perioperative measurements of interleukin-6 and α-melanocyte-stimulating hormone in cardiac transplant patients

Sakai

Latson

Whitten

et al. 1993

Journal of Cardiothoracic and Vascular Anesthesia

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Structure-function relationship in the interaction of mastoparan analogs with neutrophil NADPH oxidase

Tisch-Idelson

Fridkin

Wientjes

et al. 2001

Biochemical Pharmacology

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α-Melanocyte-Stimulating Hormone

Cited by 5 publications

References 18 publications

Molecular Cloning of a Mouse Melanocortin 5 Receptor Gene Widely Expressed in Peripheral Tissues

Molecular Cloning of a Mouse Melanocortin 5 Receptor Gene Widely Expressed in Peripheral Tissues

Perioperative measurements of interleukin-6 and α-melanocyte-stimulating hormone in cardiac transplant patients

Structure-function relationship in the interaction of mastoparan analogs with neutrophil NADPH oxidase

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