α-Oxoketenes - Preparation and Chemistry

NO-NSAIDs. Part 3: Nitric Oxide-Releasing Prodrugs of Non-steroidal Anti-inflammatory Drugs

“…We believe that these imide prodrugs 25 and 27, because of their distinct differences in metabolic stability (t 1/2 =9 min versus 150 min) and degradation pattern in rat and/or human plasma, qualify themselves as ideal candidates for such mechanistic studies. 33,34) The stability of such lactone form (i.e., TI2B) was reported to be nearly equal to o-oxoketene (TI2A) and it could be attributed to aromatic stabilization, which might be partially offset by its ring strain. The photochemical inter-conversion of TI2A and TI2B has also been reported earlier.…”

Imidoylketene dimerization and rearrangement

“…10 K. A typical IR spectrum is shown in Fig. 2 2 . Similar FVT of 10 using Ar as a carrier gas but with isolation at 70 K (i.e.…”

Computational Study on the Intramolecular Carbene-CO Coupling in M(CH2)(CO)3 Radicals (M = Co, Rh, Ir)

“…Ketenes belong to the first generation of reactive intermediates [1], along with carbenes, radicals, carbocations, and carbanions [2], and are intensively studied members of the cumulene family, with a wide variety of synthetic applications [3][4][5][6]. The most common method to access ketenes is from acyl halides via dehalogenation promoted by bases.…”