α-Pinene Enhances the Anticancer Activity of Natural Killer Cells via ERK/AKT Pathway

Jo, Hantae; Cha, Byungsun; Kim, Haneul; Brito, Sofia; Kwak, Byeong Mun; Kim, Sung Tae; Bin, Bum-Ho; Lee, Mi-Gi

doi:10.3390/ijms22020656

Cited by 45 publications

(35 citation statements)

References 59 publications

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“…The β-ionone could prevent stressinduced skin aging via inhibition of GR signaling in human dermal fibroblasts (Choi et al, 2021). The α-pinene activates natural killer (NK) cells and increases NK cells cytotoxicity, suggesting it is a potential compound for cancer immunotherapy (Jo et al, 2021).…”

Section: Volatile Constituentsmentioning

confidence: 99%

Pyracantha fortuneana (Maxim.) Li: A comprehensive review of its phytochemistry, pharmacological properties, and product development

Wang

Zhang

et al. 2022

Front. Sustain. Food Syst.

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Pyracantha fortuneana (Maxim.) Li has been used as a herbal medicine in China in its long history. Since ancient times, the fruits of P. fortuneana has been considered a functional food to improve various diseases. Many bioactive substances, including proanthocyanidins, phenols, polysaccharides, and dietary fibers, have been isolated and identified from the P. fortuneana, which possess diverse biological properties both in vitro and in vivo. Although the researches on the P. fortuneana have achieved extensive progress, the systematic study of its biological activities is still relatively lacking. In addition, accumulating researches focus on the landscape value of the P. fortuneana and the development of its by-products. The by-products of P. fortuneana, which show good development potentials in the field of agricultural production and environmental protection, are important for improving the economic value of P. fortuneana and its significance. After extensive reviewing and analyzing the existing published articles, books, and patents, this study aims to a systematic and summarized research trends of P. fortuneana and its phytochemical compositions, nutritional values, pharmacological effects and health benefits of its extracts/monomers, which would be beneficial for the future development of this medicinal plant as functional food or drugs.

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Section: Volatile Constituentsmentioning

confidence: 99%

Pyracantha fortuneana (Maxim.) Li: A comprehensive review of its phytochemistry, pharmacological properties, and product development

Wang

Zhang

et al. 2022

Front. Sustain. Food Syst.

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“…The immune infiltration profile of the CSRNP family genes in ccRCC tumor tissues was different from that in normal tissues; natural killer cells and plasmacytoid dendritic cells showed positive correlations. It is known that natural killer cells destroy various cancer cells (27)(28)(29), including renal cell carcinoma (30). Plasmacytoid dendritic cell (pDC) infiltration predicts better survival in triple-negative breast cancer (31) and melanoma (32).…”

Section: Discussionmentioning

confidence: 99%

The CSRNP Gene Family Serves as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma

2021

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The cysteine-serine-rich nuclear protein (CSRNP) family has prognostic value for various cancers. However, the association between this proteins and prognosis of clear cell renal cell carcinoma (ccRCC) remains unclear. This study aimed to determine the prognostic value of the CSRNP family for patients with ccRCC. Therefore, the gene expression profiling interactive analysis database was used to analyze the mRNA expression of CSRNP family members (CSRNPs) in relation with survival. Combined and independent prognostic values of CSRNPs were evaluated using SurvExpress and multivariate Cox regression analyses, respectively. Potential signaling pathways impacted by CSRNPs were evaluated using Metascape. Associations between the CSRNP family and immunocyte infiltration were determined from single-sample gene set enrichment analysis. Both cBioPortal and MethSurv were used to explore whether genomic and epidemic alterations might influence prognosis. We found that when both CSRNP1 and CSRNP3 had a low expression, patients with ccRCC had a worse overall survival (OS). Therefore, a prognostic signature was constructed as follows: risk score = −0.224 × expmRNA ofCSRNP1 + 0.820 × expmRNA ofCSRNP2 − 1.428 × expmRNA ofCSRNP3. We found that OS was worse in patients from the high- than from the low-risk groups (AUC = 0.69). Moreover, this signature was an independent predictor after adjusting for clinical features. Functional enrichment analysis positively associated CSRNPs with the acute inflammatory response and humoral immune response pathways. This was validated by correlating each CSRNP with 28 types of immunocytes in tumor and normal tissues. A higher expression of CSRNP1 and CSRNP3 was associated with a better prognosis in both the high- and low-mutant burden groups. Cg19538674, cg07772537, and cg07811002 of CSRNP1, CSRNP2, and CSRNP3, respectively, were the predominant DNA methylation sites affecting OS. The CSRNP gene family signature may serve as a prognostic biomarker for predicting OS in patients with ccRCC. The association between CSRNPs and immune infiltration might offer future clinical treatment options.

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“…The other very known monoterpene hydrocarbon present in black pepper essential oil is α-pinene. It increases NK (Natural killer) cell cytotoxicity and can be used in an application for cancer immunotherapy [60].…”

Section: Anticancer Activitymentioning

confidence: 99%

Black pepper: Chemical composition and biological activities

Milenković¹,

Stanojević²

2021

Adv Techol

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Black pepper (Piper nigrum L.) is a tropical plant, best known for its fruit, used as a spice all around the world. The fruits of black pepper can be processed in various ways, so there are end products such as white, black, red, and green pepper. Black pepper contains many substances such as terpenes, alkaloids, lignans, phenylpropanoids, etc., which are responsible for some of the most important biological activities: antioxidant, antimicrobial, anticancer, anti-inflammatory, analgesic, antipyretic, hepatoprotective, bio-enhancing and enzyme inhibitory activities. These activities have also been proven in clinical studies, and probably the future of black pepper research should be based on discovering the most effective way to use the active compounds of pepper for the development of herbal drugs with fewer contraindications than standard drugs. Further preclinical and clinical studies are needed to prepare and apply phytoformulations based on the black pepper isolates.

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α-Pinene Enhances the Anticancer Activity of Natural Killer Cells via ERK/AKT Pathway

Cited by 45 publications

References 59 publications

Pyracantha fortuneana (Maxim.) Li: A comprehensive review of its phytochemistry, pharmacological properties, and product development

Pyracantha fortuneana (Maxim.) Li: A comprehensive review of its phytochemistry, pharmacological properties, and product development

The CSRNP Gene Family Serves as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma

Black pepper: Chemical composition and biological activities

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