α-Pinene inhibits tumor invasion through downregulation of nuclear factor (NF)-κB-regulated matrix metalloproteinase-9 gene expression in MDA-MB-231 human breast cancer cells

Kang, Eung Shick; Lee, Da Hyun; Jung, You Jung; Shin, Soon Young; Koh, Dongsoo; Lee, Young Han

doi:10.1007/s13765-016-0175-6

Cited by 22 publications

(19 citation statements)

References 24 publications

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“…The quantitative and qualitative composition of these compounds is determined by different factors, e.g., plant origin and habitat [2,3], cultivar [4,5], plant development phase [4,6,7], seasonal variations [8,9], weather and Studies have indicated that the dominant EO components in the flower heads of A. chamissonis are similar to those found in A. montana [6,17,39], including molecules with significance emphasized and confirmed in the literature. The main EO component of A. chamissonis is alpha-pinene exhibiting antioxidative, anti-inflammatory, antimicrobial, and antiparasitic bioactivity [17,[40][41][42][43] as well as a significant effect on the inhibition of tumor invasion [44]. Another important component, caryophyllene oxide, is a dominant component in the EO of some Asteraceae species [45][46][47].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition of Essential Oil from Flower Heads of Arnica Chamissonis Less. under a Nitrogen Impact

et al. 2019

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Chamisso arnica (Arnica chamissonis Less.) is a valuable plant species used in the pharmaceutical industry due to the content of many pharmacologically active substances and the similarity of its chemical composition to that of Arnica montana—a medicinal plant commonly used in pharmacy and cosmetics. The similarity of the two plant species implies that chamisso arnica can be a pharmaceutical substitute for the mountain arnica, i.e., an endangered and endemic plant species in Europe. Chamisso arnica extracts exhibit anti-inflammatory and antiradical activity and possesses high antioxidant properties that might be helpful in preventing or delaying the progress of free radical dependent diseases. The attributes of A. chamissonis are mainly related to the content and chemical composition of essential oil. Therefore, the objective of this study was to characterize the chemical composition of essential oil derived from A. chamissonis flower heads under a nitrogen impact. The experiment was performed on experimental fields in mid-eastern Poland on two soil types (sandy and loamy soils). The nitrogen fertilizer was applied as ammonium sulfate (control, 30, 60, 90, and 120 kg N ha−1). Collection of flower heads was carried out in the full flowering phase, which was characterized by the highest content of essential oil. The chemical composition of essential oil was examined using GC-MS. Among the 75 ingredients of the volatile oil of chamisso arnica flower heads, alpha-pinene, cumene, p-cymene, germacrene D, spathulenol, decanal, caryophyllene oxide, beta-pinene, and benzene acetaldehyde were present at relatively high levels. Both the nitrogen application and the soil type had an effect on the oil concentration and the yield of the main constituents (alpha-pinene and germacrene D) with pharmacological value. Different levels of nitrogen application could be considered as a relevant way to modify the chemical composition and to increase the essential oil production.

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Section: Introductionmentioning

confidence: 99%

Chemical Composition of Essential Oil from Flower Heads of Arnica Chamissonis Less. under a Nitrogen Impact

et al. 2019

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“…The terpenoid structure is fat-soluble and constructed by isoprene molecules, terpenoid skeletons are formed from two or more units of isoprene units. In this research, terpenoids are the dominant secondary metabolite in Karo traditional oil, which make it a potent antiinflammatory medicine [11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…Alpha pinene also has the strongest immunostimulation activity and potential immunomodulating effects on natural killer cell activity and lymphocyte activation through CD 69 expression among all compounds [12]. A research from Kang et al shows that alphapinene inhibits tumor invasion through tumor necrosis factor (TNF)-α inhibition and downregulation of NF-κβ-regulated matrix metalloproteinase-9 gene expression in human breast cancer cells in a dose-dependent manner [13]. This result suggests that Karo traditional oil may potentially be developed into an anti-metastatic drug.…”

Section: Discussionmentioning

confidence: 99%

“…Alphapinene together with limonene also inhibits the leukotriene production as a mediator of inflammation; this indicates that Karo traditional oil can be used for variety of inflammatory diseases [12]. Alpha-pinene stimulates the inflammatory cell production, macrophage type-2 which is the key regulation of the wound healing process, but in the same time it suppresses the neutrophil migration, production of macrophage type-1 and pro-inflammatory cytokines, by blocking tolllike receptor-4 receptor which should be bound by DAMP and PAMP compound to stimulate the release of pro-inflammatory cytokines, this inhibits the NF-κβ, IκB kinase-β, and caspase-1 activation and suppress the MAPK pathway through decreasing of MAPK phosphorylation (ERK and JNK) in inflammatory cells and reduce the pro-inflammatory mediators such as interleukin-6, TNF-α, and cyclooxygenase-2 expression [11,13,14,16,17]. Alpha-pinene and other terpene compounds in Karo traditional oil play an important step in the inflammatory phase in wound healing [11].…”

Section: Discussionmentioning

confidence: 99%

“…Its effect on the proliferation and remodeling phase remains unknown [13]. Therefore, it is necessary to do additional research to find the mechanism of action of this Karo traditional oil in the phase of proliferation and remodeling, which accelerates the re-epithelialization process.…”

Section: Discussionmentioning

confidence: 99%

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Phytochemistry Screening and Gas Chromatography-Mass Spectrometry Analysis of Bioactive Compounds Present in Karo Traditional Oil, an Indonesian Traditional Herbal Medicine

Primadina¹,

Basori²,

Perdanakusuma³

2020

Asian J Pharm Clin Res

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Objective: The purpose of this research was to observe the bioactive compounds of Karo traditional oil by phytochemistry screening and gas chromatography-mass spectrometry (GC-MS) analysis. Alkaloid, Results: Terpenoid and flavonoid compounds were found, and no polyphenol compound from phytochemistry screening and 16 constituents were identified from the GC-MS analysis, α-pinene was found as the major component (74.47%), delta-3-carene (9.62%), 1% of octane, dodecane, camphor, undecane, isodecane, sabinene, hexadecane, nonane, and <1% tridecane, cyclohexane, pentacosane, heptadecan, limonene, and camphene. Conclusion: Karo traditional oil works as a potent anti-inflammation at the inflammation phase of the wound healing process by suppressing the pro-inflammatory cytokines and promote anti-inflammatory cytokines.

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Essential oils and their nanoformulations for breast cancer therapy

Thalappil,

Singh,

Carcereri de Prati

et al. 2023

Phytotherapy Research

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Breast Cancer (BC) is the most prevalent type of cancer in the world. Current treatments include surgery, radiation, and chemotherapy but often are associated with high toxicity to normal tissues, chemoresistance, and relapse. Thus, developing novel therapies which could combat these limitations is essential for effective treatment. In this context, phytochemicals are increasingly getting popular due to their safety profile, ability to efficiently target tumors, and circumvent limitations of existing treatments. Essential Oils (EOs) are mixtures of various phytochemicals which have shown potential anticancer activity in preclinical BC models. However, their clinical translation is limited by factors such as high volatility, low stability, and poor solubility. Nanotechnology has facilitated their encapsulation in a variety of nanostructures and proven to overcome these limitations. In this review, we have efficiently summarized the current knowledge on the anticancer effect of EOs and constituents in both in in vitro and in in vivo BC models. Further, we also provide a descriptive account on the potential of nanotechnology in enhancing the anti‐BC activity of EOs and their constituents. The papers discussed in this review were selected using the keywords “antiproliferative Essential Oils in breast cancer,” “anticancer activity of Essential Oil in breast cancer,” and “cytotoxicity of Essential Oils in breast cancer” performed in PubMed and ScienceDirect databases.

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α-Pinene inhibits tumor invasion through downregulation of nuclear factor (NF)-κB-regulated matrix metalloproteinase-9 gene expression in MDA-MB-231 human breast cancer cells

Cited by 22 publications

References 24 publications

Chemical Composition of Essential Oil from Flower Heads of Arnica Chamissonis Less. under a Nitrogen Impact

Chemical Composition of Essential Oil from Flower Heads of Arnica Chamissonis Less. under a Nitrogen Impact

Phytochemistry Screening and Gas Chromatography-Mass Spectrometry Analysis of Bioactive Compounds Present in Karo Traditional Oil, an Indonesian Traditional Herbal Medicine

Essential oils and their nanoformulations for breast cancer therapy

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