α-pinene triggers oxidative stress and related signaling pathways in A549 and HepG2 cells

Jin, Kyong-Suk; Bak, Min-Ji; Jun, Mira; Lim, Ho-Jin; Jo, Wan-Keun; Jeong, Woo-Sik

doi:10.1007/s10068-010-0189-5

Cited by 23 publications

(12 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the basis of the chemical composition, the monoterpenes myrcene and α-pinene were the most abundant compounds of PLEO, suggesting that the antiproliferative effects of PL might be possibly mediated by these two compounds. In accord, previous evidence indicated that myrcene and α-pinene might exert significant cytotoxic effects on different cancer cell lines [ 22 – 24 ]. Nevertheless, the involvement of other PLEO minor constituents should not be ruled out; indeed, the terpenes limonene, β-caryophyllene, and β-elemene have also shown significant anticancer activities both in vitro and in vivo models [ 9 ], indicating potential synergies among EO components.…”

Section: Discussionsupporting

confidence: 81%

“…When experiments were repeated in the presence of GSH as antioxidant, no intracellular ROS accumulation and no inhibition of cancer cell growth were observed in FTC-133 cells after PL administration, thus indicating that PLEO might act as antiproliferative agent in a ROS-dependent manner. In accord, several terpenic EO constituents, such as α-pinene and β-caryophyllene, have demonstrated to specifically induce the production of ROS within cancer cells without increasing oxidative stress in normal cells [ 22 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative stress and apoptosis induction in human thyroid carcinoma cells exposed to the essential oil from Pistacia lentiscus aerial parts

et al. 2017

View full text Add to dashboard Cite

BackgroundEssential oils from the aerial parts (leaves, twigs and berries) of Pistacia lentiscus (PLEO) have been well characterized for their antibacterial and anti-inflammatory properties; however, poor information exists on their potential anticancer activity.MethodsIncreasing concentrations of PLEO (0.01–0.1% v/v, 80–800 μg/ml) were administered to a wide variety of cultured cancer cells from breast, cervix, colon, liver, lung, prostate, and thyroid carcinomas. Fibroblasts were also included as healthy control cells. Cell viability was monitored by WST-8 assay up to 72 hours after PLEO administration. The intracellular formation of reactive oxygen species (ROS), the induction of apoptosis, and the enhancement of chemotherapeutic drug cytotoxicity by PLEO were further investigated in the most responsive cancer cell line.ResultsA dose-dependent reduction of tumor cell viability was observed upon PLEO exposure; while no cytotoxic effect was revealed in healthy fibroblasts. FTC-133 thyroid cancer cells were found to be the most sensitive cells to PLEO treatment; accordingly, an intracellular accumulation of ROS and an activation of both the extrinsic and intrinsic apoptotic pathways were evidenced in FTC-133 cells after PLEO administration. Furthermore, the cytotoxic effect of the antineoplastic drugs cisplatin, 5-fluorouracil and etoposide was enhanced in PLEO-exposed FTC-133 cells.ConclusionTaking into account its mode of action, PLEO might be considered as a promising source of natural antitumor agents which might have therapeutic potential in integrated oncology.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Oxidative stress and apoptosis induction in human thyroid carcinoma cells exposed to the essential oil from Pistacia lentiscus aerial parts

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Hassan et al (2010) [26] suggested that α-terpineol inhibits tumor cell growth by a mechanism that involves inhibition of the NF-kB (nuclear factor kappa B). Jin et al (2010) [27] showed that α-pinene, also found in this study, triggered oxidative stress and related signaling pathways in the HepG2 and A549 tumor cells.…”

Section: Resultssupporting

confidence: 71%

Chemical Characterization and in Vitro Antitumor Activity of the Essential Oils from the Leaves and Flowers of Callistemon viminalis

Oliveira¹,

Cardoso²,

Ionta³

et al. 2015

AJPS

View full text Add to dashboard Cite

The objective of this study was to characterize and verify the in vitro antitumor activity of essential oils (EOs) extracted from the leaves and flowers of Callistemon viminalis. The EOs were extracted by hydrodistillation using a modified Clevenger apparatus. The identification and quantification of constituents were performed on a gas chromatograph coupled to a mass spectrometer and a gas chromatograph with a flame ionization detector. The antitumoral activity was evaluated by a colorimetric assay (MTS) using different cell lines derived from human tumors (breast, lung, glioblastoma, and melanoma). The major constituents of the EOs of leaves and flowers were similar, only quantitative differences being observed. The compounds 1,8-cineole, α-pinene and α-terpineol were found in concentrations of 50.4%, 25.8% and 8.7% in the EOs obtained from the leaves and 48.8%, 24.5% and 3.9% in the EOs obtained from the flowers, respectively. The cytotoxic activity of the EOs was observed only in melanoma cultures (HT144). Cultures treated for 48 h with EOs from leaves and flowers (200 µg·mL −1 ) reduced the viability by 40% and 25%, respectively. Thus, the antiproliferative activity of the EO from leaves was more pronounced than the EO from flowers in cells derived from melanoma.

show abstract

“…Later, it was revealed in human hepatoma Bel-7402 cells that the proapoptotic effect of α-pinene is associated with induction of G2/M cell cycle arrest ( 63 ). In addition, α-pinene triggers oxidative stress signaling pathways in A549 and HepG2 cells ( 64 ). However, Kusuhara et al .…”

Section: Terpenes and Tumormentioning

confidence: 99%

Terpenes from Forests and Human Health

et al. 2017

View full text Add to dashboard Cite

Forest bathing has beneficial effects on human health via showering of forest aerosols as well as physical relaxation. Terpenes that consist of multiple isoprene units are the largest class of organic compounds produced by various plants, and one of the major components of forest aerosols. Traditionally, terpene-containing plant oil has been used to treat various diseases without knowing the exact functions or the mechanisms of action of the individual bioactive compounds. This review categorizes various terpenes easily obtained from forests according to their anti-inflammatory, anti-tumorigenic, or neuroprotective activities. Moreover, potential action mechanisms of the individual terpenes and their effects on such processes, which are described in various in vivo and in vitro systems, are discussed. In conclusion, the studies that show the biological effectiveness of terpenes support the benefits of forest bathing and propose a potential use of terpenes as chemotherapeutic agents for treating various human diseases.

show abstract

α-pinene triggers oxidative stress and related signaling pathways in A549 and HepG2 cells

Cited by 23 publications

References 31 publications

Oxidative stress and apoptosis induction in human thyroid carcinoma cells exposed to the essential oil from Pistacia lentiscus aerial parts

Oxidative stress and apoptosis induction in human thyroid carcinoma cells exposed to the essential oil from Pistacia lentiscus aerial parts

Chemical Characterization and in Vitro Antitumor Activity of the Essential Oils from the Leaves and Flowers of Callistemon viminalis

Terpenes from Forests and Human Health

Contact Info

Product

Resources

About