α-Pyrones from the marine-derived actinomycete Nocardiopsis dassonvillei subsp. dassonvillei XG-8-1

Fu, Peng; Li, Peipei; Gong, Qianhong; Wang, Yi; Wang, Pei; Zhu, Weiming

doi:10.1039/c3ra43656j

Cited by 23 publications

(14 citation statements)

References 28 publications

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“…During PA14 infection of C. elegans , the pathogens produce virulence-related membrane vesicles, leading to the accretion of biofilm-like material on host intestinal cells (Irazoqui et al, 2010 ). There have been several reports on natural product-based small molecules from marine organisms, including actinomycetes showing potency against virulence of PA14 (Hentzer et al, 2003 ; Fu et al, 2013 ; Naik et al, 2013 ; Yaniv et al, 2017 ). Our results showed that Streptomyces sp.…”

Section: Discussionmentioning

confidence: 99%

“…As result, a promising number of novel secondary metabolites with biological properties are constantly being reported from marine actinomycetes (Feling et al, 2003 ; Lam, 2006 ; Solanki et al, 2008 ; Kang et al, 2015 ). Compounds originating from marine microbes that attenuate virulence through inhibition of quorum sensing system without bacteriocidal activities have also been reported (Fu et al, 2013 ; Naik et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

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A Marine Actinomycete Rescues Caenorhabditis elegans from Pseudomonas aeruginosa Infection through Restitution of Lysozyme 7

et al. 2017

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The resistance of Pseudomonas aeruginosa to conventional antimicrobial treatment is a major scourge in healthcare. Therefore, it is crucial that novel potent anti-infectives are discovered. The aim of the present study is to screen marine actinomycetes for chemical entities capable of overcoming P. aeruginosa infection through mechanisms involving anti-virulence or host immunity activities. A total of 18 actinomycetes isolates were sampled from marine sediment of Songsong Island, Kedah, Malaysia. Upon confirming that the methanolic crude extract of these isolates do not display direct bactericidal activities, they were tested for capacity to rescue Caenorhabditis elegans infected with P. aeruginosa strain PA14. A hexane partition of the extract from one isolate, designated as Streptomyces sp. CCB-PSK207, could promote the survival of PA14 infected worms by more than 60%. Partial 16S sequence analysis on this isolate showed identity of 99.79% with Streptomyces sundarbansensis. This partition did not impair feeding behavior of C. elegans worms. Tested on PA14, the partition also did not affect bacterial growth or its ability to colonize host gut. The production of biofilm, protease, and pyocyanin in PA14 were uninterrupted, although there was an increase in elastase production. In lys-7::GFP worms, this partition was shown to induce the expression of lysozyme 7, an important innate immunity defense molecule that was repressed during PA14 infection. GC-MS analysis of the bioactive fraction of Streptomyces sp. CCB-PSK207 revealed the presence of methyl esters of branched saturated fatty acids. In conclusion, this is the first report of a marine actinomycete producing metabolites capable of rescuing C. elegans from PA14 through a lys-7 mediated activity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Marine Actinomycete Rescues Caenorhabditis elegans from Pseudomonas aeruginosa Infection through Restitution of Lysozyme 7

et al. 2017

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“…"Nocapyrone I" 43 and "M" 46 displayed inhibition of quorum sensing (QS) controlled gene expression in Chromobacterium violaceum CV026 and Pseudomonas aeruginosa QSIS-lasI biosensors. 106 Very clearly the naming of these metabolites needs revision. Saline culture of Nocardiopsis sp.…”

Section: Marine-sourced Bacteria (Excluding From Mangroves)mentioning

confidence: 99%

Marine natural products

et al. 2015

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This review covers the literature published in 2013 for marine natural products (MNPs), with 982 citations (644 for the period January to December 2013) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1163 for 2013), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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“…Three novel α-pyrones; nocapyrone H (1) , nocapyrone I (2) , and nocapyrone M (3) (Tables 1, 3), were extracted from Nocardiopsis dassonvillei subsp. dassonvillei XG-8-1 inhibited QS controlled virulence in P. aeruginosa QSIS-lasI biosensor and Chromobacterium violaceum CV026 at a concentration of 100 μg/mL (Fu et al, 2013). At 200 μg/ml concentration, the crude extract of Nocardiopsis sp.…”

Section: Family: Nocardiopsaceae; Genus: Nocardiopsismentioning

confidence: 99%

Profile of the Intervention Potential of the Phylum Actinobacteria Toward Quorum Sensing and Other Microbial Virulence Strategies

Sarveswari

Solomon

2019

Front. Microbiol.

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The rapid dissemination of antimicrobial resistance amongst microorganisms and their deleterious effect on public health has propelled the exploration of alternative interventions that target microbial virulence rather than viability. In several microorganisms, the expression of virulence factors is controlled by quorum sensing systems. A comprehensive understanding into microbial quorum sensing systems, virulence strategies and pathogenesis has exposed potential targets whose attenuation may alleviate infectious diseases. Such virulence attenuating natural products sourced from the different phyla of bacteria from diverse ecosystems have been identified. In this review, we discuss chemical entities derived from the phylum Actinobacteria that have demonstrated the potential to inhibit microbial biofilms, enzymes, and other virulence factors both in vivo and in vitro. We also review Actinobacteria-derived compounds that can degrade quorum sensing signal molecules, and the genes encoding such molecules. As many Actinobacteria-derived compounds have been translated into pharmaceutically important agents including antibiotics, the identification of virulence attenuating compounds from this phylum exemplifies their significance as a prospective source for anti-virulent drugs.

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α-Pyrones from the marine-derived actinomycete Nocardiopsis dassonvillei subsp. dassonvillei XG-8-1

Cited by 23 publications

References 28 publications

A Marine Actinomycete Rescues Caenorhabditis elegans from Pseudomonas aeruginosa Infection through Restitution of Lysozyme 7

A Marine Actinomycete Rescues Caenorhabditis elegans from Pseudomonas aeruginosa Infection through Restitution of Lysozyme 7

Marine natural products

Profile of the Intervention Potential of the Phylum Actinobacteria Toward Quorum Sensing and Other Microbial Virulence Strategies

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