α-Tocopherol and Hippocampal Neural Plasticity in Physiological and Pathological Conditions

Ambrogini, Patrizia; Betti, Michele; Galati, Claudia; Palma, Michael Di; Lattanzi, Davide; Savelli, David; Galli, Francesco; Cuppini, Riccardo; Minelli, Andrea

doi:10.3390/ijms17122107

Cited by 32 publications

(18 citation statements)

References 282 publications

(360 reference statements)

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“…Mostly interestingly, vitamin E produced, by a nonantioxidant mechanism, a negative regulation of protein kinase C (PKC) . Wide confirmation of these results has been obtained in different laboratories .…”

Section: The Discovery Of the Nonantioxidant Properties Of Vitamin Ementioning

confidence: 99%

Vitamin E – The Next 100 Years

Khadangi

Azzi

2018

IUBMB Life

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α‐Tocopherol is the only tocopherol that has been shown to prevent the human deficiency disease Ataxia with Isolated Vitamin E Deficiency (AVED), and thus it is the only one that, for humans, can be called vitamin E. Vitamin E in addition to preventing AVED has documented immune boosting properties and an activity against nonalcoholic hepatosteatosis and low‐grade inflammation. Epidemiological studies indicating that vitamin E could prevent cardiovascular events, neurodegenerative disease, macular degeneration, and cancer were in general not confirmed by clinical intervention studies. Vitamin E and some of its metabolites modulate cell signaling and gene transcription. Future research is needed to achieve a better understanding of the molecular events leading to gene regulation by vitamin E, especially in its phosphorylated form. Isolation and characterization of the vitamin E kinase and vitamin E phosphate phosphatase will help in the understanding of cell regulation processes modulated by vitamin E. A clarification of the pathogenesis of AVED remains an important goal to be achieved. © 2018 IUBMB Life, 71(4):411–415, 2019

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Section: The Discovery Of the Nonantioxidant Properties Of Vitamin Ementioning

confidence: 99%

Vitamin E – The Next 100 Years

Khadangi

Azzi

2018

IUBMB Life

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“…It has been manifested that glycolic acid could strongly potentiate the antioxidant action of alpha-tocopherol [51], which possessed better antioxidant properties, and involved in regulating multiple of cell signaling molecules and their target proteins [52]. Moreover, antioxidant supplementation may be an effective therapeutic strategy for metabolic syndrome [43].…”

Section: Discussionmentioning

confidence: 99%

Metabolomics Reveals Protection of Resveratrol in Diet-Induced Metabolic Risk Factors in Abdominal Muscle

Chen

Zhang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Abdominal obesity is recognized as the main reason of metabolic syndrome, which is closely related to disordered skeletal and/or abdominal muscle metabolic functions. Metabolomics is a comprehensive assessment system in biological metabolites. The aim of our present study is to investigate the diet-induced metabolic risk factors by metabolic in the abdominal muscles and clarify the relationship between atheroprotective effects of Resveratrol (Rev) and abdominal muscles metabolic components during the development of atherosclerosis. Methods: The mice were randomly divided into three groups including normal group (N), high fat diet (HFD or H) group and high fat diet with Rev treated group (HR). GC-MS combined with pattern recognition approaches were employed to obtain comprehensive metabolic signatures and related differential metabolites after 24 week HFD feeding. Oil Red O staining and Electron microscopy technology (EMT) were employed to detect the size of fatty plaques and intracellular lipid accumulation, respectively. Results: The result indicated that 22 types of metabolites in the abdominal muscles were obviously altered by HFD feeding group. Moreover, Rev treatment obviously increased 11 different kinds of metabolites, most of which were involved in the carbohydrate, amino acid and lipid metabolisms. Importantly, these elevated different metabolites were involved in pathways mainly related to galactose metabolism, alanine, aspartate and glutamate metabolism, glyoxylate and dicarboxylate metabolism in abdominal muscles. Oil Red O staining and Electron microscopy showed less lipid accumulation in the lesions and decreased intracellular lipid deposition in the foam cells in HR group. Conclusions: We concluded that Rev produced a beneficial effect partially by modulating multiple metabolism pathways and metabolites in the abdominal muscles, which may provide a new protective mechanism of Rev on the progression of atherosclerosis. These notably changed metabolites might be potential biomarkers or therapeutic targets during development of metabolic syndrome and atherosclerosis.

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“…Vitamin E also plays a role in maintaining hippocampal plasticity and may affect the generation and clearance of amyloid-b (Ab) peptides, which is the main component of the amyloid plaques found in Alzheimer's patients (130,131).…”

Section: Vitamin Ementioning

confidence: 99%

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2017

Cereal Foods World

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α-Tocopherol and Hippocampal Neural Plasticity in Physiological and Pathological Conditions

Cited by 32 publications

References 282 publications

Vitamin E – The Next 100 Years

Vitamin E – The Next 100 Years

Metabolomics Reveals Protection of Resveratrol in Diet-Induced Metabolic Risk Factors in Abdominal Muscle

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