α‐Tocopherol prooxidant effect in aqueous media: Increased autoxidation rate of linoleic acid

Cillard, Josiane; Cillard, P.; Cormier, M.; Girre, L.

doi:10.1007/bf02668254

Cited by 107 publications

(52 citation statements)

References 5 publications

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“…Methyl linoleate containing 0.5 mol% cY-tocopherol showed a linear accumulation of MeLOOH with depletion of the c!-tocopherol. Therefore, c!-tocopherol at a high concentration acts as a pro-oxidant (Cillard et al, 1980;Terao & Matsushita, 1986). The main products were 3, 5, c!-tocopherol dimer (6) and c!-tocopherol trirner (7) in the 0.5-g sample.…”

Section: A-tocopherol As the Free Radical Scavengermentioning

confidence: 96%

Vitamin E: Mechanism of Its Antioxidant Activity.

Yamauchi

1997

FSTI

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The antioxidant activity of vitamin E (a-tocopherol) during the peroxidation of unsaturated lipids has been reviewed based on its reaction products. Free-radical scavenging reactions of a-tocopherol take place via the a-tocopheroxyl radical as an intermediate. If a suitable free radical is present, a non-radical product can be formed from the coupling of the free radical with the a-tocopheroxyl radical. The reaction products of a-tocopherol with lipid-peroxyl radicals are 8a-(lipid-dioxy)-a-tocopherones which are hydrolyzed to a-tocopherylquinone. If the supply of oxygen is insufficient, a-tocopherol can trap the carbon-centered radicals of lipids to form 6-0-(lipidalkyl)-a-tocopherols. On the other hand, the dimer and trimer of a-tocopherol is formed by the bimolecular self-reaction of the a-tocopheroxyl radical in a reaction mixture containing a large amount of a-tocopherol. The other product-forming pathway yields isomeric epoxy-a-tocopherylquinones and their precursors, epoxyhydroperoxy-a-tocopherones, but the mechanism of this pathway remains unknown. The reaction products of other vitamin E compounds (7-and 6-tocopherols) during lipid peroxidation are almost the same as those formed from the a-tocopherol. The tocopheroxyl radicals of 7-and 6-tocopherols prefer to react with each other to form dimeric products that are still effective as antioxidants.

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Section: A-tocopherol As the Free Radical Scavengermentioning

confidence: 96%

Vitamin E: Mechanism of Its Antioxidant Activity.

Yamauchi

1997

FSTI

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“…When it reacts with a free radical it becomes a radical itself, and if there is not enough ascorbic acid for its regeneration it will remain in this highly reactive state and promote the autoxidation of linoleic acid (Cillard et al, 1980).…”

Section: Prooxidantsmentioning

confidence: 99%

A review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives

Carocho

Ferreira

2013

Food and Chemical Toxicology

1,383

907

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Many studies have been conducted with regard to free radicals, oxidative stress and antioxidant activity of food, giving antioxidants a prominent beneficial role, but, recently many authors have questioned their importance, whilst trying to understand the mechanisms behind oxidative stress. Many scientists defend that regardless of the quantity of ingested antioxidants, the absorption is very limited, and that in some cases prooxidants are beneficial to human health. The detection of antioxidant activity as well as specific antioxidant compounds can be carried out with a large number of different assays, all of them with advantages and disadvantages. The controversy around antioxidant in vivo benefits has become intense in the past few decades and the present review tries to shed some light on research on antioxidants (natural and synthetic) and prooxidants, showing the potential benefits and adverse effects of these opposing events, as well as their mechanisms of action and detection methodologies. It also identifies the limitations of antioxidants and provides a perspective on the likely future trends in this field.

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“…L'effet prooxydant de l'acide ascorbique en présence de fer est bien documenté. De même nous avons mis en évidence un effet prooxydant de l'alpha tocophérol à fortes concentrations [19,20]. Les flavonoïdes comme la quercétine et la myricétine peuvent également présenter des propriétés pro-oxydantes [21].…”

Section: Les Effets Prooxydantsunclassified

Mécanismes de la peroxydation lipidique et des anti-oxydations

Cillard¹,

Cillard²

2006

OCL

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α‐Tocopherol prooxidant effect in aqueous media: Increased autoxidation rate of linoleic acid

Cited by 107 publications

References 5 publications

Vitamin E: Mechanism of Its Antioxidant Activity.

Vitamin E: Mechanism of Its Antioxidant Activity.

A review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives

Mécanismes de la peroxydation lipidique et des anti-oxydations

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