1987
DOI: 10.1210/endo-121-4-1412
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α-Transforming Growth Factor in the Bovine Anterior Pituitary Gland: Secretion by Dispersed Cells and Immunohistochemical Localization*

Abstract: A growth factor secreted by bovine calf anterior pituitary cells in culture was purified, and its N-terminal amino acid sequence was determined. This sequence shows near-identity with human and rat alpha-transforming growth factor (alpha TGF). With the use of an anti-alpha TGF monoclonal antibody generated against a C-terminal rat alpha TGF synthetic peptide, alpha TGF-like material was localized by immunohistochemical techniques in the cytoplasm of normal bovine adenohypophysial cells. The antibody staining w… Show more

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Cited by 89 publications
(42 citation statements)
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“…Transforming growth factor (TGF) a is found in a variety of normal mammalian tissues including lactotrophs of the pituitary gland [25], brain [27], keratinocyte [10], gastrointestinal mucosa [9], mammary gland [49], and macrophages [4]. Estrogen administration has been found to induce hyperplasia of the pituitary gland with a high level of TGFa mRNA expression in ovariectomized adult rats [8].…”
Section: Growth Factorsmentioning
confidence: 99%
“…Transforming growth factor (TGF) a is found in a variety of normal mammalian tissues including lactotrophs of the pituitary gland [25], brain [27], keratinocyte [10], gastrointestinal mucosa [9], mammary gland [49], and macrophages [4]. Estrogen administration has been found to induce hyperplasia of the pituitary gland with a high level of TGFa mRNA expression in ovariectomized adult rats [8].…”
Section: Growth Factorsmentioning
confidence: 99%
“…In the case of the growth of pituitary cells, transforming growth factor-(TGF-) is one of the candidates for the oestrogen-induced growth factors (Borgundvaag et al 1992). TGF-is produced in pituitary glands of several species (Kudlow & Kobrin 1984, Kobrin et al 1987, Lazar & Blum 1992. In rat pituitary cells, TGF-mRNA expression was detected in somatotrophs, gonadotrophs and mammotrophs .…”
Section: Introductionmentioning
confidence: 99%
“…EGF can modulate the secretion of pituitary hormones in both normal (Ikeda et al 1984, Miyake et al 1985, Childs et al 1991 and tumor pituitary cells (Schonbrunn et al 1980, Aanestad et al 1993. Transforming growth factor-(TGF-), a member of the EGF family, which can thus also act through the EGF-R on target cells, has been detected in the normal pituitary gland (Kobrin et al 1987, Ezzat et al 1995, Fan & Childs 1995, and has been implicated in pituitary tumorigenesis (Finley & Ramsdell 1994).…”
Section: Introductionmentioning
confidence: 99%