α-Tricalcium phosphate cement reinforced with silk fibroin: A high strength biomimetic bone cement with chloride-substituted hydroxyapatite

Cassel, Júlia Bünecker; Tronco, Matheus C.; Melo, Beatriz A. de; Oliveira, Fernanda dos Santos de; Santos, Luís Alberto Loureiro dos

doi:10.1016/j.jmbbm.2023.105936

Cited by 4 publications

(1 citation statement)

References 45 publications

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“…Unfortunately, self-hardening CaPO 4 formulations with ceramic properties become brittle after setting, while the hardening time may not be suitable for clinical procedures [478]. Therefore, several attempts have been made to transform them into biocomposites to improve their properties, for example, by adding PEG [479,480], polylactide [481], PLGA [482], gelatin [414,[483][484][485][486], osteocalcin/collagen [487], alginic acid [488], chitin [489], chitosan [451,490], fibrin glue [491], silk fibroin [492,493], silanized HPMC [494], CMC [495], PVA fibers with CMC [496] and without CMC [497], CMC/gelatin/fullerenol [498], bioactive glass [499][500][501][502], bioactive glass functionalized with hypoxia conditioned medium [503], calcium silicate [504][505][506], cockle shell powders [507], metals [508], magnetic nanoparticles [509], and so on. Light-curing formulations have also been prepared [510,511].…”

Section: Self-hardening Biocompositesmentioning

confidence: 99%

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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The goal of this review is to present a wide range of hybrid formulations and composites containing calcium orthophosphates (abbreviated as CaPO4) that are suitable for use in biomedical applications and currently on the market. The bioactive, biocompatible, and osteoconductive properties of various CaPO4-based formulations make them valuable in the rapidly developing field of biomedical research, both in vitro and in vivo. Due to the brittleness of CaPO4, it is essential to combine the desired osteologic properties of ceramic CaPO4 with those of other compounds to create novel, multifunctional bone graft biomaterials. Consequently, this analysis offers a thorough overview of the hybrid formulations and CaPO4-based composites that are currently known. To do this, a comprehensive search of the literature on the subject was carried out in all significant databases to extract pertinent papers. There have been many formulations found with different material compositions, production methods, structural and bioactive features, and in vitro and in vivo properties. When these formulations contain additional biofunctional ingredients, such as drugs, proteins, enzymes, or antibacterial agents, they offer improved biomedical applications. Moreover, a lot of these formulations allow cell loading and promote the development of smart formulations based on CaPO4. This evaluation also discusses basic problems and scientific difficulties that call for more investigation and advancements. It also indicates perspectives for the future.

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Section: Self-hardening Biocompositesmentioning

confidence: 99%

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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Thermoplastic polyurethane/POSS nanohybrids: Synthesis, morphology, and biological properties

Ozimek,

Malarz,

Mrozek‐Wilczkiewicz

et al. 2024

J Biomed Mater Res

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Recent studies show good osteoinductive properties of polyurethanes modified with polyhedral oligomeric silsesquioxanes (POSS). In this work, three types of POSS; propanediolisobutyl‐POSS (PHI‐POSS), disilanolisobutyl‐POSS (DSI‐POSS), and octahydroxybutyl‐POSS (OCTA‐POSS) were chemically incorporated into linear polyurethane based on an aliphatic isocyanate, hexamethylene diisocyanate (HDI), to obtain new nanohybrid PU‐POSS materials. The full conversion of POSS was confirmed by Fourier transform infrared spectroscopy (FTIR‐ATR) spectra of the model reactions with pure HDI. The materials obtained were investigated by FTIR, SEM‐EDS, and DSC. The DSC studies showed the thermoplasticity of the obtained materials and apparently good recovery. 30‐day immersion in SBF (simulated body fluid) revealed an increase in the rate of deposition of hydroxyapatite (HAp) for the highest POSS loadings, resulting in thick layers of hydroxyapatite (~60–40 μm), and the Ca/P ratio 1.67 (even 1.785). The structure and properties of the inorganic layer depend on the type of POSS, the number of hard segments, and those containing POSS, which can be tailored by changing the HDI/poly(tetramethylene glycol) (PTMG) ratio. Furthermore, the obtained composites revealed good biocompatibility, as confirmed by cytotoxicity tests conducted on two cell lines; normal human dermal fibroblasts (NHDF) and primary human osteoblasts (HOB). Adherent cells seeded on the tested materials showed viability even after a 48‐h incubation. After this time, the population of viable, and proliferating cells exceeded 90%. Bioimaging studies have shown the fibroblast and osteoblast cells were well attached to the surface of the tested materials.

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Reinforcement of injectable premixed α-tricalcium phosphate cements with silk fibroin solutions

Cassel,

Tronco,

Paim

et al. 2024

Materials Today Communications

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α-Tricalcium phosphate cement reinforced with silk fibroin: A high strength biomimetic bone cement with chloride-substituted hydroxyapatite

Cited by 4 publications

References 45 publications

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Thermoplastic polyurethane/POSS nanohybrids: Synthesis, morphology, and biological properties

Reinforcement of injectable premixed α-tricalcium phosphate cements with silk fibroin solutions

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