α1-Adrenergic Receptors Control the Activity of Sinoatrial Node by Modulating Transmembrane Transport of Chloride Anions

Voronina, Y. A.; Fedorov, A. V.; Chelombitko, M. A.; Piunova, U. E.; Kuzmin, V. S.

doi:10.1134/s1990747823070061

Biochem. Moscow Suppl. Ser. A

2023

DOI: 10.1134/s1990747823070061

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α1-Adrenergic Receptors Control the Activity of Sinoatrial Node by Modulating Transmembrane Transport of Chloride Anions

Y. A. Voronina,

A. V. Fedorov,

M. A. Chelombitko

et al.

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2024

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Chloride channels and transporters – role in the electrical activity of pacemaker and working myocardium

Voronina,

Karhov,

Kuzmin

2024

Uspehi fiziologičeskih nauk

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Chlorine anions have a significant influence on the electrophysiological properties of excitable tissues, including myocardium. Chlorine anions and transmembrane chloride currents (ICl) determine the configuration of action potentials (AP) in various regions of hearts. Disruption of transmembrane chloride transport leads to alterations in normal electrical activity, resulting in cardiac pathologies and arrhythmias. Currently, chloride conductivity and expression in the heart and a functional role have been confirmed for several types of macromolecules. These channels include CFTR, ClC-2, CaCC (TMEM16), and VRAC (LRRC8x). Additionally, chloride cotransporters (KCC, NKCC) and chloride-bicarbonate exchangers make a significant contribution to the regulation of intracellular chlorid ion concentration ([Cl-]i) and, consequently, the equilibrium potential for chloride ions (ECl). The review covers the mechanisms by which chloride transmembrane transport influences the bioelectrical activity of cardiomyocytes and the potential functions of chloride and chloride currents in specialized regions of the heart.

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Chloride channels and transporters – role in the electrical activity of pacemaker and working myocardium

Voronina,

Karhov,

Kuzmin

2024

Uspehi fiziologičeskih nauk

View full text Add to dashboard Cite

show abstract

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α1-Adrenergic Receptors Control the Activity of Sinoatrial Node by Modulating Transmembrane Transport of Chloride Anions

Cited by 1 publication

References 39 publications

Chloride channels and transporters – role in the electrical activity of pacemaker and working myocardium

Chloride channels and transporters – role in the electrical activity of pacemaker and working myocardium

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