α1-Adrenoceptor subtypes mediating antinatriuresis in Wistar and stroke-prone spontaneously hypertensive rats

Sattar, M. A.; Johns, Edward J.

doi:10.1016/0014-2999(95)00637-0

Cited by 11 publications

(9 citation statements)

References 13 publications

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“…Further, studies have shown that up to 15％ to 20％ decrease in the glomerular hemodynamic had only a little in‰uence on the magnitude of the associated antinatriuresis and antidiuresis. 18,19,27) Similarly, we observed a more signiˆcant decrease in the renal cortical perfusion in SHRHNa group in response to phenylephrine infusion. Moreover, renal cortical perfusion does not represent the total blood ‰ow to the kidney as we have not measured the medullary blood ‰ow.…”

Section: Discussionsupporting

confidence: 49%

“…The rationale of the use of proposed dose of the drug to carry out renal tubular function in the study is based previous studies from our laboratory and others. 8,15,18) Statistical Analysis…”

Section: Measurement Of Mean Arterial Blood Pressure Renal Cortical mentioning

confidence: 99%

“…Once the completion of the surgical process, 2 ml of inulin (10 mg/ml) in saline (150 mM NaCl) was given as a primer via the jugular vein cannula and an infusion of saline containing inulin 10 mg/ml and sodium pentobarbitone (12.5 mg/kg/h) was begun at a rate of 6 ml/h via the iliac arterial cannula. 18) Experimental Protocol for Renal Tubular Study…”

Section: Surgical Preparation For Renal Functional Studiesmentioning

confidence: 99%

“…The clearance period was started 5 10 min after the reinfusion of the blood sample when the cardiovascular variables had settled. 18,19) During each phase, three 15-min urine clearances samples were collected and the volumes obtained during each clearance period were measured gravimetrically and UFR is subsequently calculated. Further, plasma and urine samples were assayed for inulin using the modiˆed method 20) and the glomerularˆltration was calculated as the clearance of inulin.…”

Section: Surgical Preparation For Renal Functional Studiesmentioning

confidence: 99%

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A Special Focus on the Role of α<sub>1D</sub>-Adrenoreceptors in the Assessment of Renal Tubular Sodium Re-absorptive Responses in Spontaneously Hypertensive Rats Subjected to High Sodium Diet

et al. 2011

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a 1D -Adrenoceptors are involved in the genesis/maintenance of hypertension in spontaneously hypertensive rats (SHR). This study aims to investigate the role of a 1D -adrenoceptors in the antinatriuretic and antidiuretic responses in SHR subjected to high sodium (SHRHNa) and normal sodium (SHRNNa) intake for six weeks. Renal inulin clearance study was performed in which the antinatriuretic and antidiuretic responses to phenylephrine were examined in the presence and absence of a 1D -adrenoceptors blocker BMY7378. Data, mean±S.E.M. were subjected to ANOVA with signiˆcance at p＜0.05. Results show that feeding SHR for six weeks with high salt did not cause any change in blood pressure. SHRHNa had higher (all p＜0.05) urine ‰ow rate (UFR), fractional and absolute excretion of sodium (FE Na and U Na V) compared to SHRNNa. Phenylephrine infusion produced signiˆcant reduction in UFR, FE Na and U Na V in both SHRHNa and SHRNNa. The antidiuretic and antinatriuretic responses to phenylephrine in both groups were attenuated in the presence of BMY7378. Moreover, the antidiuretic and antinatriuretic responses to phenylephrine and BMY7378 were independent on any signiˆcant changes in renal and glomerular hemodynamics in both groups. Thus we conclude that high sodium intake did not bring any further increase in blood pressure of SHR, however, it results in exaggerated natriuresis and diuresis in SHRHNa. Irrespective of dietary sodium changes, a 1 -adrenoceptors are involved in mediating the antinatriuretic and antidiuretic responses to phenylephrine in SHR. Further, high sodium intake did not signiˆcantly in‰uence the functionality of a 1D -adrenoceptors in mediating the adrenergically induced antinatriuresis and antidiuresis.

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Section: Discussionsupporting

confidence: 49%

Section: Measurement Of Mean Arterial Blood Pressure Renal Cortical mentioning

confidence: 99%

Section: Surgical Preparation For Renal Functional Studiesmentioning

confidence: 99%

Section: Surgical Preparation For Renal Functional Studiesmentioning

confidence: 99%

See 2 more Smart Citations

A Special Focus on the Role of α<sub>1D</sub>-Adrenoreceptors in the Assessment of Renal Tubular Sodium Re-absorptive Responses in Spontaneously Hypertensive Rats Subjected to High Sodium Diet

et al. 2011

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“…Although an increase in AP itself acts to increase diuresis, concurrent sympathetic activation or α1-adrenergic stimulation has antinatiruretic effects. 50 Further studies are required to quantify the time-courses of the respective and combined effects of increased AP and adrenergic stimulation on diuresis during baroreflex-mediated AP regulation.…”

Section: Study Limitationsmentioning

confidence: 99%

Predominant Role of Neural Arc in Sympathetic Baroreflex Resetting of Spontaneously Hypertensive Rats

Sata

Kawada

Shimizu

et al. 2015

Circ J

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592SATA Y et al. Circulation JournalOfficial Journal of the Japanese Circulation Society http://www. j-circ.or.jp classified as a short-term blood pressure control system, 8 carotid baroreflex activation therapy has succeeded in reducing blood pressure in patients with resistant hypertension for more than 1 year, 9 suggesting a potential role of the arterial baroreflex in the long-term regulation of blood pressure. 10 Considering the multifactorial and complex nature of hypertension, further research is needed to understand how sympathetic nerve activity (SNA) and AP are determined in hypertension. The arterial baroreflex system constitutes a key link between the autonomic nervous system and the cardiovascular system. The reflex arc of baroreflex can be divided into 2 principal arcs: the neural arc from pressure input to SNA, and the peripheral arc from SNA to AP. 11,12 Under normal physiological conditions, because the arterial baroreflex operates as a closedloop feedback control system, it is difficult to separately quantify neural and peripheral arc characteristics.The behavior of a system might be described by dynamic and static characteristics. The dynamic characteristics determine he arterial baroreflex control of arterial pressure (AP) is known to reset to a higher input pressure range in hypertension. 1 To cope with the resetting, carotid baroreflex activation is proposed as a potential treatment of drugresistant hypertension. 2,3 Involvement of both neural and cardiovascular factors has been proposed in the pathophysiology of hypertension. Previous studies have demonstrated that sympathetic outflow from the central nervous system is increased in spontaneously hypertensive rats (SHR). 4,5 Peripheral factors such as cardiac hypertrophy and increased vascular resistance are also considered responsible for high AP in SHR. 6 Abnormality in vascular function is also reported in hypertensive patients. 7 Editorial p 510Device-based neuromodulation therapy has increasingly drawn scientific interest. While the arterial baroreflex has been Background: There is ongoing controversy over whether neural or peripheral factors are the predominant cause of hypertension. The closed-loop negative feedback operation of the arterial baroreflex hampers understanding of how arterial pressure (AP) is determined through the interaction between neural and peripheral factors.

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Autonomic regulation of kidney function

Johns¹

2013

Autonomic Nervous System

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α1-Adrenoceptor subtypes mediating antinatriuresis in Wistar and stroke-prone spontaneously hypertensive rats

Cited by 11 publications

References 13 publications

A Special Focus on the Role of α<sub>1D</sub>-Adrenoreceptors in the Assessment of Renal Tubular Sodium Re-absorptive Responses in Spontaneously Hypertensive Rats Subjected to High Sodium Diet

A Special Focus on the Role of α<sub>1D</sub>-Adrenoreceptors in the Assessment of Renal Tubular Sodium Re-absorptive Responses in Spontaneously Hypertensive Rats Subjected to High Sodium Diet

Predominant Role of Neural Arc in Sympathetic Baroreflex Resetting of Spontaneously Hypertensive Rats

Autonomic regulation of kidney function

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