2012
DOI: 10.1016/j.neubiorev.2012.07.011
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α2 adrenergic receptor dysregulation in depressive disorders: Implications for the neurobiology of depression and antidepressant therapy

Abstract: Dysfunction in noradrenergic neurotransmission has long been theorized to occur in depressive disorders. The α2 adrenergic receptor (AR) family, as a group of key players in regulating the noradrenergic system, has been investigated for involvement in the neurobiology of depression and mechanisms of antidepressant therapies. However, a clear picture of the α2ARs in depressive disorders has not been established due to the existence of apparently conflicting findings in the literature. In this article, we report… Show more

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Cited by 102 publications
(63 citation statements)
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References 150 publications
(206 reference statements)
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“…Blockade of α 2A AR activity would reduce the detrimental effects of NE on AD-related pathology through this receptor subtype and would further boost NE, given that the α 2A AR is also an autoreceptor, to improve cognition. Increased α 2A AR density and/or activity have been associated with type 2 diabetes mellitus and depression (30,31), both of which are risk factors for AD.…”
Section: Discussionmentioning
confidence: 99%
“…Blockade of α 2A AR activity would reduce the detrimental effects of NE on AD-related pathology through this receptor subtype and would further boost NE, given that the α 2A AR is also an autoreceptor, to improve cognition. Increased α 2A AR density and/or activity have been associated with type 2 diabetes mellitus and depression (30,31), both of which are risk factors for AD.…”
Section: Discussionmentioning
confidence: 99%
“…Increased density of α 2 -adrenoceptors has repeatedly been reported in brains and platelets of subjects with major depressive disorder (see review by Cottingham and Wang (2012)). This increase is preferentially observed for the high-affinity conformational state (Callado et al, electroconvulsive shock) induces a down-regulation and/or desensitisation of brain α 2 - (Esteban et al, 1999;Giralt and García-Sevilla, 1989;Mateo et al, 2001;Mongeau et al, 1994;Pilc and Vetulani, 1982;Sacchetti et al, 2001;Smith et al, 1981) and β-adrenoceptors (Duncan et al, 1985;Gillespie et al, 1979;Heal et al, 1989;Holoubek et al, 2004;Ordway et al, 1991).…”
Section: Introductionmentioning
confidence: 91%
“…Antidepressants can target almost all components of the monoaminergic system to induce their pharmacological actions (15,16).Most genetic studies have considered set of functional polymorphisms relevant to monoaminergic neurotransmissionin depression (17)(18)(19). The ARs, consisting of β, α 1 , and α 2 receptors, are the cellular mediators of noradrenergic neurotransmission.…”
Section: Introductionmentioning
confidence: 99%