2013
DOI: 10.1074/jbc.m112.421529
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α3Na+/K+-ATPase Deficiency Causes Brain Ventricle Dilation and Abrupt Embryonic Motility in Zebrafish

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Cited by 32 publications
(30 citation statements)
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“…C. Atp1a3a / b knockdown zebrafish. Knockdown of Atp1a3a or Atp1a3b RNA transcript by ~65% in 60 hpf embryos had similar phenotypic effects 85 .…”
Section: Figurementioning
confidence: 87%
See 1 more Smart Citation
“…C. Atp1a3a / b knockdown zebrafish. Knockdown of Atp1a3a or Atp1a3b RNA transcript by ~65% in 60 hpf embryos had similar phenotypic effects 85 .…”
Section: Figurementioning
confidence: 87%
“…Similarly, Atp1a3a mRNA did not cross-rescue the phenotype of Atp1a3b -KD embryos. Both morphants display abnormal spontaneous motility and an abnormal response to tactile stimulation with a needle, 85 suggesting that both α3 paralogues are required for embryonic motility.…”
Section: Biological Consequences Of Disease-causing Atp1a3 Mutationsmentioning
confidence: 99%
“…Critical function in maintaining ionic homeostasis has stage-specific developmental impact 43 ; however, the role of stress in protein expression and function is unclear. Other channelopathies have similar associations of disrupted membrane function with provoking stimulus, as in variants of FHM.…”
Section: Atp1a3 Pathophysiologymentioning
confidence: 99%
“…47 The relative infrequency of seizures reported in RDP and the variable epilepsy burden in AHC further highlights the likely contribution of age and developmentally specific protein expression. 43 …”
Section: Atp1a3 Pathophysiologymentioning
confidence: 99%
“…Embryonic central nervous system (CNS) development is an ideal context in which to explore and understand the signals responsible for achieving the necessary target morphology. Developmental mispatterning is the cause of debilitating disorders, such as spina bifida (unclosed neural tube) (Copp andGreene, 2010, Detrait et al, 2005), anencephaly (small brain) (Copp and Greene, 2010, Detrait et al, 2005, Wallingford, 2006 and also increased susceptibility to degenerative disorders like Parkinson's, Alzheimer's, and autism (Doganli et al, 2013, Goldman et al, 2013, Pratt and Khakhalin, 2013. Hence, understanding how large-scale patterning of the brain normally occurs is a pre-requisite for major biomedical breakthroughs addressing birth defects and repairing injuries.…”
Section: Introductionmentioning
confidence: 99%