αvβ3 Integrin in central nervous system tumors

Lim, Michael; Guccione, Samira; Haddix, Terri; Sims, Leroy; Cheshier, Samuel; Chu, Pauline; Vogel, Hannes; Harsh, Griffith R.

doi:10.1016/j.humpath.2005.03.014

Cited by 32 publications

(21 citation statements)

References 13 publications

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“…ErbB2 and ErbB4 receptor overexpression was found in more than 75% of pediatric ependymomas and correlated with tumor proliferative index and prognosis [20], with similar findings in adult supratentorial ependymoma. Other studies reported additional molecular changes, including increased expression of integrin α v β 3 in a high percentage of intracranial ependymomas, as well as expression of annexin A1 and cyclooxygenase 2 [21][22][23]. A single nucleotide polymorphism in the platelet-derived growth factor (PDGF) receptor-α gene promoter region in ependymomas has been reported, suggesting that the PDGF pathway may have a functional role in tumor biology [24].…”

Section: Molecular Pathway Abnormalitiesmentioning

confidence: 99%

Ependymomas in Adults

Gilbert

Rudà

Soffietti

2010

Curr Neurol Neurosci Rep

140

119

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Ependymomas are rare primary central nervous system tumors in adults. They occur most commonly in the spinal cord, where histopathologic evaluation is critical to differentiate the grade I myxopapillary ependymoma from the grade II ependymoma or grade III anaplastic ependymoma. Brain ependymomas are either grade II or III. Treatment for all grades and types includes maximum surgical resection. For myxopapillary ependymoma, complete removal while maintaining capsule integrity may be curative. Some grade II ependymomas may be observed carefully after imaging confirms complete resection, but grade III tumors require adjuvant radiation treatment. Radiation commonly is given to the region of tumor, except in cases in which there is imaging or cerebrospinal fluid evidence of tumor dissemination. Chemotherapy has not been studied extensively, although most reports suggest only modest benefit. Ongoing laboratory studies have uncovered important signal transduction pathways that may be better therapeutic targets, leading to the development of clinical trials using targeted agents.

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Section: Molecular Pathway Abnormalitiesmentioning

confidence: 99%

Ependymomas in Adults

Gilbert

Rudà

Soffietti

2010

Curr Neurol Neurosci Rep

140

119

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“…In this process of angiogenesis, integrin a V h 3 directs extracellular matrix adhesion to support the recruitment of endothelial progenitor cells. Additionally, malignant gliomas have been shown to express a V h 3 in great density on their cell surface (7,12,13). Thus, integrin a V h 3 is a reliable marker to distinguish malignant from benign cancer phenotype due to its strong correlation with tumor invasiveness, metastasis, and poor clinical outcome (14 -20).…”

mentioning

confidence: 99%

Integrin αvβ3-Targeted Radioimmunotherapy of Glioblastoma Multiforme

Veeravagu

Liu

Niu

et al. 2008

Clinical Cancer Research

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“…Thus we suggest that there is a regulation pathway of the αV integrin gene by HOXD11, even if the expression pattern of the αV integrin in tumours contrasts with the functions that this protein seems to have in neoplastic cells (40)(41)(42)(43). However, further analysis is necessary to confirm these data.…”

Section: Discussionmentioning

confidence: 73%

“…This integrin is essential to cellular migration (40,41), and it may contribute to angiogenesis (42) and survival in metastatic cells (43). On the other hand, the αVß1 integrin mediates the effects of the fibronectin, a matrix glycoprotein that regulates important cellular pathways such as proliferation and adhesion (44).…”

Section: Discussionmentioning

confidence: 99%

Quantitative expression of the homeobox and integrin genes in human gastric carcinoma

Degl’Innocenti¹,

Castiglione²,

Buccoliero³

et al. 2007

Int J Mol Med

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Abstract. The homeobox (HOX) genes are a large family of regulator genes involved in the control of developmental processes and cell differentiation. The HOX genes encode transcription factors, and an increasing number of studies have shown that these genes may be implicated in the growth and the progression of many types of tumours. The present study investigated the expression of the HOX and integrin genes and their relationships in gastric carcinoma. We analyzed the RNA expression of 13 HOX genes from HOXA, C and D clusters and αV, α5 and α8 integrin genes in 24 gastric cancer samples by quantitative real-time PCR. The results showed that the HOXA2 gene and the α8 integrin gene had a lower expression in tumour samples than in normal gastric mucosas. The comparison between the HOX and integrin genes showed that HOXA2 and αV integrin expression presented the same trend in 83% of the samples. Moreover, in cancer samples that expressed the HOXD11 gene, the expression of αV integrin was lower with respect to normal mucosas. The different roles of HOX and integrin genes in gastric carcinoma remain to be fully elucidated. These findings suggest that the HOX genes may play a critical role in the genesis, maintenance and diffusion of gastric carcinoma.

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αvβ3 Integrin in central nervous system tumors

Cited by 32 publications

References 13 publications

Ependymomas in Adults

Ependymomas in Adults

Integrin αvβ3-Targeted Radioimmunotherapy of Glioblastoma Multiforme

Quantitative expression of the homeobox and integrin genes in human gastric carcinoma

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