β-3 adrenergic receptor gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population

Abstract

Increasing studies demonstrated that genetic susceptibility attributes to the development of gestational diabetes mellitus (GDM). The polymorphisms of the β-3 adrenergic receptor(β-3AR) gene have been found to be of great importance in bodyweight elevation and dyslipidaemias. We aimed to determine the influence of β-3AR polymorphisms on the GDM risk. Thus, we performed a case-control study including 136 GDM cases and 138 controls to evaluate the relation between the rs201607471 and susceptibility to GDM. Likelihood ratios X2 analysis showed the distribution of the genotype frequency (rs201607471 in β-3AR gene) was accorded with the Hardy-Weinberg genetic equilibrium. Although no significant association between rs201607471 alleles and GDM susceptibility (Chi-square test, P > .05), we observed that β-3AR gene rs201607471 CT genotype was significantly prevalent in GDM (Chi-square test, P < .05). Moreover, we observed that β-3AR gene rs201607471 C > T was significantly associated with an increased risk of GDM using the recessive model (CC vs CT/TT: P = .026) and the additive model (CC vs CT vs TT: P = .038). These data indicate that β-3AR rs201607471 may be a helpful susceptibility marker for GDM in Chinese pregnant women.

Gestational Diabetes Mellitus: The Genetic Susceptibility Behind the Disease

“…The ADRB3 gene is located on human chromosome 8p11.23, encoding ADRB3, which is primarily expressed in the adipose tissue. It is a member of the G protein-coupled receptor superfamily that mediates heat generation and fat decomposition stimulated by catecholamines and occupies a significant position in the activation of energy storage and utilization of lipid decomposition and internal environmental stability of glucose [69][70][71][72]. Therefore, the gene expression defect caused by an ADRB3 mutation is the initial factor in insulin resistance [70].…”

“…It is a member of the G protein-coupled receptor superfamily that mediates heat generation and fat decomposition stimulated by catecholamines and occupies a significant position in the activation of energy storage and utilization of lipid decomposition and internal environmental stability of glucose [69][70][71][72]. Therefore, the gene expression defect caused by an ADRB3 mutation is the initial factor in insulin resistance [70]. Guan et al, in a meta-analysis of five studies that included 1239 participants with GDM from four Caucasian and one Asian region, demonstrated that the Trp64Arg (rs4994) polymorphism in ADRB3 was associated with GDM susceptibility in Caucasian populations in Europe [73].…”

“…Guan et al, in a meta-analysis of five studies that included 1239 participants with GDM from four Caucasian and one Asian region, demonstrated that the Trp64Arg (rs4994) polymorphism in ADRB3 was associated with GDM susceptibility in Caucasian populations in Europe [73]. Another study found that the rs201607471 CT genotype was significantly correlated with an increased risk for GDM in a Han Chinese population [70].…”

The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions

“…Genetic factors, including IR and IRS1 gene polymorphisms [ 48 ], directly affect insulin signaling. In addition, polymorphisms of other genes, such as the beta 3 adrenergic receptor gene [ 49 ] and the uncoupling protein gene [ 50 ], lead to insulin resistance by favoring abdominal obesity. Several molecular mechanisms, including apoptosis, oxidative stress, mitochondrial dysfunction, and inflammation, are all involved in insulin resistance [ 44 , 51 ].…”