β-Adrenergic activation reveals impaired cardiac calcium handling at early stage of diabetes

Buijs, Jorn op den; Miklós, Zsuzsanna; Riel, Natal A. W. van; Prestia, Christina M.; Szenczi, Orsolya; Tóth, András; Vusse, Ger J.; Szabó, Csaba; Ligeti, L.; Ivanics, Tamás

doi:10.1016/j.lfs.2004.08.018

Cited by 24 publications

(28 citation statements)

References 41 publications

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“…The method is more robust against measurement noise compared to when the data was classified a priori (i.e. separately from the estimation procedure), (Op den Buijs et al, 2005;Van Riel and Van der Vusse 2002). The one-step ahead method (5) requires that all model states are measured outputs (2).…”

Section: Discussionmentioning

confidence: 99%

“…diabetes related cardiomyopathy (Choi et al, 2002;Op den Buijs et al, 2005) and cardiac ischemia/reperfusion induced damage (Ivanics et al, 2001). A properly controlled cyclic alteration of [Ca 2+ ] i is a prerequisite for appropriate heart performance (Bers, 2002 …”

Section: Physiological Backgroundmentioning

confidence: 99%

“…A previously published simple, physiologically meaningful model of calcium handling was adopted (Op den Buijs et al, 2005 …”

Section: Model Componentsmentioning

confidence: 99%

“…These studies followed a black-box approach, using Piece-Wise Auto-Regressive eXogenous (PWARX) models. Grey-box approaches for hybrid descriptions of physiological systems have been previously employed using heuristic signal analysis and data preprocessing to first classify the data, irrespective of the subsequent parameter estimation problem (Op den Buijs et al, 2005;Van Riel and Van der Vusse 2002;Van Riel et al, 2003). Obtained estimates were highly sensitive to the (erroneous) classification of the data.…”

Section: Introductionmentioning

confidence: 99%

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One-Step Ahead Prediction for Parameter Estimation in Physiological Hybrid Models

Riel

Juloski

Buijs

2005

IFAC Proceedings Volumes

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Identification of hybrid systems is complex because it is not a priori known which data is generated by which discrete mode of the system. A novel procedure is presented for the simultaneous determination of the model parameters and classification of the data. Initial parameter estimates are obtained based on a priori knowledge of the modes of the system. Next, the data points are subsequently classified and with each new classified data point the parameter estimates are refined. The proposed procedure is applied in the estimation of parameters in a hybrid description of calcium cycling in the intact heart.

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Section: Discussionmentioning

confidence: 99%

Section: Physiological Backgroundmentioning

confidence: 99%

“…A previously published simple, physiologically meaningful model of calcium handling was adopted (Op den Buijs et al, 2005 …”

Section: Model Componentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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One-Step Ahead Prediction for Parameter Estimation in Physiological Hybrid Models

Riel

Juloski

Buijs

2005

IFAC Proceedings Volumes

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“…Since the plasma levels of both Epi and NE were reduced in the 8-wk diabetic animals, there could also be a reduced production of aminochromes and therefore a reduced susceptibility to catecholamine-induced arrhythmias. The reduced susceptibility of catecholamineinduced arrhythmias could also be, in part, related to the reported decrease in β 1 -and β 2 -adrenoceptors in diabetic hearts (43,44). The α 1 -adrenoceptor is known to modulate intracellular Ca 2+ -concentration through the activation of phospholipase C-mediated generation of inositol trisphosphate and diacylglycerol (20,45).…”

Section: Dose Of Epimentioning

confidence: 99%

Susceptibility of Diabetic Heart to Catecholamine-induced Arrhythmias is Independent of Contractile Dysfunction

Adameová

Elimban²,

Rodriguez-Leyva

et al. 2014

Serbian Journal of Experimental and Clinical Research

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Background: Diabetes is associated with myocardial electrical instability and prolongation of action potential duration that result in disturbances in the rhythm of the heart. Objective: Th is study was undertaken to examine the role of circulating catecholamines in abnormal cardiac rhythm and contractility during diff erent stages of diabetes. Methods: Diabetes was induced in male Sprague-Dawley rats with streptozotocin (STZ; 65 mg/kg, i.v.). Epinephrine (4-128 μg/kg, i.v.) -induced arrhythmias and plasma levels of epinephrine (Epi) and norepinephrine (NE) were determined in control, 4- and 8-wk diabetic animals. Echocardiography was used to assess cardiac remodeling and contractile function. Results: Although diabetes induced cardiac dysfunction, there were no significant differences in cardiac output, ejection fraction, left ventricle (LV) dimensions, LV fractional shortening between the 4- and 8-wk diabetic animals. Th e electrocardiogram of both diabetic groups showed deep S wave as well as changes in T wave and ST segment. In addition, prolongation of the RR interval in the 4- and 8-wk diabetic animals was seen, while prolongation of the QT and PR intervals were only seen in the 8-wk diabetic animals. Th e severity of Epi-induced ventricular arrhythmias, as assessed by arrhythmia score, was significantly lower in the 8-wk diabetic rats, as compared to the 4-wk diabetic animals. Circulating Epi levels were significantly decreased in the 8-wk diabetic rats, whereas NE levels were increased in the 4-wk diabetic rats. Conclusions: Th e sensitivity of the diabetic heart to catecholamine- triggered arrhythmias may be dependent on circulating Epi rather than NE and thus it can be proposed that the increased incidence of sudden cardiac death in diabetics may not be associated with response to catecholamines.

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Microsphere‐Based Real‐Time Calcium Sensing

Sánchez‐Martín

Cuttle

Mittoo³

et al. 2006

Angewandte Chemie

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Nachweis in der Zelle: Mikrokügelchen (2 μm), die kovalent mit Calciumsensoren beladen sind, können effizient in lebende Zellen eingebracht werden, um die intrazellulären Änderungen der Ca2+‐Konzentration in Echtzeit zu analysieren. Das Bild zeigt die ratiometrische Fluoreszenzanalyse (Verhältnis 400/475 nm) der Freisetzung von Ca2+‐Ionen in mit den Mikrokügelchen beladenen Zellen in Echtzeit.

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β-Adrenergic activation reveals impaired cardiac calcium handling at early stage of diabetes

Cited by 24 publications

References 41 publications

One-Step Ahead Prediction for Parameter Estimation in Physiological Hybrid Models

One-Step Ahead Prediction for Parameter Estimation in Physiological Hybrid Models

Susceptibility of Diabetic Heart to Catecholamine-induced Arrhythmias is Independent of Contractile Dysfunction

Microsphere‐Based Real‐Time Calcium Sensing

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