β-Adrenergic Receptor and Insulin Resistance in the Heart

Mangmool, Supachoke; Denkaew, Tananat; Parichatikanond, Warisara; Kurose, Hitoshi

doi:10.4062/biomolther.2016.128

Cited by 36 publications

(27 citation statements)

References 138 publications

(199 reference statements)

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“…Chronic activation of the sympathetic nervous system and the associated increase in catecholamines such as epinephrine and norepinephrine are another hallmark of PS [ 127 ]. These catecholamines contribute to insulin resistance in the heart by activating β -adrenergic receptors ( β -AR) [ 128 ]. Activation of β -AR induces oxidative stress in cardiomyocytes, adipocytes, and endothelial cells, at least partly by β 2-AR-mediated upregulation of Nox [ 128 – 132 ].…”

Section: Pathways To Cellular Stresses In Insulin Target Cellsmentioning

confidence: 99%

“…These catecholamines contribute to insulin resistance in the heart by activating β -adrenergic receptors ( β -AR) [ 128 ]. Activation of β -AR induces oxidative stress in cardiomyocytes, adipocytes, and endothelial cells, at least partly by β 2-AR-mediated upregulation of Nox [ 128 – 132 ]. The β 3-AR activates hormone-sensitive lipase in adipocytes and thus promotes accumulation of free fatty acids and the associated increase in ceramide synthesis and MAPK activation [ 133 ].…”

Section: Pathways To Cellular Stresses In Insulin Target Cellsmentioning

confidence: 99%

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Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance

Onyango

2018

Oxidative Medicine and Cellular Longevity

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Insulin resistance (IR), a key component of the metabolic syndrome, precedes the development of diabetes, cardiovascular disease, and Alzheimer's disease. Its etiological pathways are not well defined, although many contributory mechanisms have been established. This article summarizes such mechanisms into the hypothesis that factors like nutrient overload, physical inactivity, hypoxia, psychological stress, and environmental pollutants induce a network of cellular stresses, stress responses, and stress response dysregulations that jointly inhibit insulin signaling in insulin target cells including endothelial cells, hepatocytes, myocytes, hypothalamic neurons, and adipocytes. The insulin resistance-inducing cellular stresses include oxidative, nitrosative, carbonyl/electrophilic, genotoxic, and endoplasmic reticulum stresses; the stress responses include the ubiquitin-proteasome pathway, the DNA damage response, the unfolded protein response, apoptosis, inflammasome activation, and pyroptosis, while the dysregulated responses include the heat shock response, autophagy, and nuclear factor erythroid-2-related factor 2 signaling. Insulin target cells also produce metabolites that exacerbate cellular stress generation both locally and systemically, partly through recruitment and activation of myeloid cells which sustain a state of chronic inflammation. Thus, insulin resistance may be prevented or attenuated by multiple approaches targeting the different cellular stresses and stress responses.

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Section: Pathways To Cellular Stresses In Insulin Target Cellsmentioning

confidence: 99%

Section: Pathways To Cellular Stresses In Insulin Target Cellsmentioning

confidence: 99%

Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance

Onyango

2018

Oxidative Medicine and Cellular Longevity

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“…Insulin promotes glucose uptake in cardiomyocytes through activation of an InsR-mediated phosphatidylinositol 3-kinase (PI3K)-Akt pathway, which mobilizes glucose transporter 4 (GLUT4) vesicles to the cell surface for glucose uptake [1]. Interestingly, stimulation of βAR in heart also induces an additive effect on insulin-induced glucose uptake; and this effect is mediated by phosphorylation of Akt in threonine 308 through protein kinase A (PKA)/Ca 2+ -dependent pathway [2, 3]. On the cellular level, stimulation with either insulin or catecholamines antagonizes the ability of the other to activate glucose transport and to modulate cardiomyocyte survival [4, 5].…”

Section: Sympathetic Nervous Activity and Insulin Resistance In Heartmentioning

confidence: 99%

“…These effects are also associated with suppression of myocardial fatty acid oxidation, greater glucose consumption, increased SERCA2a and phospholamban mRNA expression [91, 92]. In contrary, long-term βAR stimulation inhibits insulin-induced phosphorylation of ERK1/2 and JNK [2], which are required for insulin to exert its protective effect against the hypoxia-induced activation of pro-apoptotic caspase-3 [2]. Together, these data suggests that the correlation between cardiac sympathetic function and insulin sensitivity contributes to IR and subsequently outcomes in failing ischemic human hearts, supporting the use of insulin and/or a combination of selective β 1 AR-blocker and β 2 AR agonist in treatment of acute I/R injury.…”

Section: Insulin and βAr Signaling In Ischemia And Reperfusionmentioning

confidence: 99%

Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart

Wang

Xiang

2017

Trends in Endocrinology & Metabolism

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Recent advances show that insulin may affect β adrenergic receptor (βAR) signaling in heart, to modulate cardiac function in clinically relevant states such as diabetes and heart failure. Conversely, activation of βAR regulates cardiac glucose uptake and promotes insulin resistance in HF. We discussed recent characterization on the interaction between cardiac insulin receptor and βAR in myocardium, in which insulin stimulation cross talk with cardiac βAR via insulin receptor substrate-dependent and G protein receptor kinase 2-mediated phosphorylation of β2AR. The insulin-induced phosphorylation promotes β2AR coupling to Gi and expression of phosphodiesterase 4, which inhibit cardiac adrenergic signaling and compromise cardiac contractile function. These progresses might support new approaches for effectively prevention or treatment of obesity-or diabetes-related heart failure.

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“…And HTSeq v6.0 was used to count the number of fragments for each gene in each sample. Selection of the insulin signaling pathway [64,65]. The candidate genes under selection in duck domestication are shown in red.…”

Section: Rna-seq and Gene Expression Analysismentioning

confidence: 99%

Whole-genome Resequencing Provides Insights into the Population Structure and Domestication Signatures of Ducks in Eastern China

Feng

Zeng

Yang

et al. 2020

Preprint

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Background: Ducks are an ancient domesticated animal with high economic value, uesd for its meat, eggs, and feathers. However, the origin of indigenous Chines ducks remains elusive. To address this question, we performed whole-genome resequencing to explore the genetic relationships among the domestic ducks and wild ducks in eastern China and to identify the genomic differences shaped by artificial selections. Results: The whole genomes of 60 ducks from eastern China were sequenced, with an average effective sequencing depth of ~6× per individual. The results of population and demographic analysis indicate that all individuals from the same breed gather together, and domestic ducks form a cluster separating from wild ducks. By applying selective sweep analysis, we identified that several candidate genes, important pathways and GO categories associated with artificial selection were functionally related to cellular adhesion, type 2 diabetes, lipid metabolism, the cell cycle, liver cell proliferation, and muscle functioning in domestic ducks.Conclusion: Genetic structure analysis showed that the domesticated ducks were not direct descendants of the mallard or Spot-billed duck and probably originated from an unknown population. During the long history of artificial selection, domesticated ducks have developed a complex biological adaptation to captivity.

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β-Adrenergic Receptor and Insulin Resistance in the Heart

Cited by 36 publications

References 138 publications

Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance

Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance

Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart

Whole-genome Resequencing Provides Insights into the Population Structure and Domestication Signatures of Ducks in Eastern China

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