β-Adrenoceptor Blockade and Migraine

Weerasuriya, K; Patel, L.; Turner, Paul

doi:10.1046/j.1468-2982.1982.0201033.x

Cited by 50 publications

(43 citation statements)

References 45 publications

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“…Following the observation by Lima and Turner (1982) that treatment of patients with essential hypertension with beta-receptor blocking drugs was accompanied by increasing lymphocyte responses not only to isoprenaline, but also to PGI2, Weerasuryia et al (1982) suggested that treatment of migraine with beta-adrenoceptor blocking drugs might lead to increased sensitivity to PGI2. This awaits investigation, but the present study failed to demonstrate any generalized change in responsiveness to PGI2 in migraine patients compared with matched nonmigrainous control subjects.…”

Section: Discussionmentioning

confidence: 99%

Beta-adrenoceptor and epoprostenol (prostacyclin) responsiveness of lymphocytes in migraine patients

Kilfeather¹,

Massarella²,

Gorgolewska³

et al. 1984

Postgraduate Medical Journal

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SummaryBeta-adrenoceptor blocking drugs are of prophylactic value in some patients with migraine. Beta-adrenoceptor responsiveness as measured by lymphocyte cAMP responsiveness to isoprenaline has, therefore, been compared in ten untreated classical migraine patients and ten matched non-migraine control subjects. Lymphocyte responsiveness to epoprostenol (prostacyclin, PGI2) was also compared. No difference in response to either agent was found between the two groups. A generalized abnormality of betaadrenoceptor function does not appear to be present in classical migraine, but a defect localized to specific vascular regions cannot be excluded.KEY WORDS: isoprenaline, cyclic AMP. IntroductionThe relationship between cardiovascular, neurological and haematological factors in the pathogenesis of migraine is not understood nor, consequently, is the mode of action of prophylactic migraine treatments. As a preliminary study to examination of beta-adrenoceptor and PGI2 receptor functional status during prophylactic treatment of classical migraine with beta-blockers, we have examined the general responsiveness of these vasodilating receptor systems during attack free periods. Beta-adrenoceptor and PGI2 receptor responsiveness was examined on lymphocytes by measuring isoprenaline and PGI2

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Section: Discussionmentioning

confidence: 99%

Beta-adrenoceptor and epoprostenol (prostacyclin) responsiveness of lymphocytes in migraine patients

Kilfeather¹,

Massarella²,

Gorgolewska³

et al. 1984

Postgraduate Medical Journal

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“…With regard to the beta-blockers, six have been shown in randomized, double-blind, placebo-controlled studies to be effective in migraine prevention [25]. These beta-blockers are: atenolol, bisoprolol, metoprolol, nadolol, propranolol, and timolol.…”

Section: Treatmentmentioning

confidence: 99%

Chronic daily headache

Spierings

2003

J Headache Pain

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Chronic daily headache relates to the daily or almost daily occurrence of headache in a nonparoxysmal pattern. In this review, I discuss the presentation, development, outcome, and treatment of chronic daily headache. In the context of the development of chronic daily headache, a headache continuum is presented along with its underlying pathophysiology. The treatment section covers rebound headache, analgesic and vasoconstrictor withdrawal, and the use of long-acting opioids in intractable patients. The review concludes with a discussion of hemicrania continua, an indomethacin-responsive headache syndrome.

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“…Propranolol has an established role in the prophylaxis of migraine, but its mechanism of action in this condition remains uncertain (Weerasuriya et al, 1982). The varying dosages required for effective control of attack in different patients indicates that there is unlikely to be a simple relationship between serum propranolol concentration and its effectiveness.…”

Section: Introductionmentioning

confidence: 99%

Propranolol pharmacokinetics during the menstrual cycle

Abdu-Aguye

Dunlop

Patel

et al. 1986

Postgraduate Medical Journal

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Summary:The pharmacokinetics of propranolol during menstruation and in the mid menstrual cycle have been studied in nine young women taking a single 80 mg tablet on each occasion. There were wide between-individual differences in the serum concentration at any given time (4-5 fold at peak concentrations) but the serum concentration time curves within individuals showed only mild variations. The differences between the average pharmacokinetic parameter estimates for the group did not differ significantly between the two periods of study.

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β-Adrenoceptor Blockade and Migraine

Cited by 50 publications

References 45 publications

Beta-adrenoceptor and epoprostenol (prostacyclin) responsiveness of lymphocytes in migraine patients

Beta-adrenoceptor and epoprostenol (prostacyclin) responsiveness of lymphocytes in migraine patients

Chronic daily headache

Propranolol pharmacokinetics during the menstrual cycle

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