Β-Adrenoceptor BLOCKERS, PLASMA-POTASSIUM, AND EXERCISE

Carlsson, Enar; Fellenius, E.; Lundborg, Per; Svensson, Lennart

doi:10.1016/s0140-6736(78)91893-7

Cited by 123 publications

(34 citation statements)

References 7 publications

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“…In contrast propranolol significantly potentiated exercise-induced hyperkalaemia and the normalisation of plasma potassium during recovery following exercise was delayed. These results are similar to those obtained by other groups (Macdonald et al, 1984;Carlsson et al, 1978;Leenan et al, 1980;Kullmer et al, 1985;Williams et al, 1985). In addition free fatty acid concentrations fell significantly during exercise while taking propranolol and the return to baseline values was delayed.…”

Section: Discussionsupporting

confidence: 91%

A comparison of the effects of flosequinan, a new vasodilator, and propranolol on sub‐maximal exercise in healthy volunteers.

Lewis¹,

Kendall²,

Smith³

et al. 1989

Brit J Clinical Pharma

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1 The effects of steady state flosequinan, a new vasodilator, and propranolol, on glucose mobilisation, lipolysis and plasma potassium concentration during sub-maximal exercise testing were investigated in a double-blind, randomised, three-way crossover study in 12 healthy volunteers. 2 Plasma glucose, potassium and free fatty acid concentration during and after exercise on flosequinan were similar to those on placebo. Exercise heart rates were 7% (+9.2 beats min-) higher on flosequinan compared with placebo (P < 0.05). During exercise on propranolol plasma glucose concentrations were comparable with those on placebo but plasma potassium concentrations were higher (mean increase 0.26 mmol 1-1, P < 0.01) whereas free fatty acid concentrations were lower (mean decrease 0.10 mmol 1-1, P < 0.01). As expected the heart rate on exercise was 25% less (-35 beats min-') on propranolol (P < 0.05). 3 These data suggest that, in contrast to propranolol, flosequinan does not adversely affect the mobilisation of the two major sources of energy during sub-maximal exercise.

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Section: Discussionsupporting

confidence: 91%

A comparison of the effects of flosequinan, a new vasodilator, and propranolol on sub‐maximal exercise in healthy volunteers.

Lewis¹,

Kendall²,

Smith³

et al. 1989

Brit J Clinical Pharma

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“…101 The release of potassium appears to be related to adrenergic stimulation 16 and is blocked by beta-adrenergic blockade. 102 The gradation based on the severity of exercise ranges from minimal increases with walking 1~ to as much as 2.0 mEq-L -1 after exhaustive exercise. ~04 In the normal subject, all of these potassium increases return toward normal within a matter of a few minutes after the termination of the activity.…”

Section: Exercisementioning

confidence: 99%

Potassium and anaesthesia

1993

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“…The reason for the reduction in exercise capacity with 3-adrenoceptor antagonists is unclear, but factors such as chronotropic and inotropic stimulation, reduced cardiac output and peripheral blood flow (Epstein et al, 1965;McSorley & Warren, 1978;Pearson et al, 1979), lack of substrate for the working muscles (Lundborg et al, 1981), increased levels of potassium and direct effect on muscle contraction (Bowman, 1980;Carlsson et al, 1978;Gullestad et al, 1989a), and mental factors such as subjective perception of fatigue (Gullestad et al, 1988;Pearson etal., 1979) have been suggested. In the present study, the reduction in heart rate and blood pressure was not proportional to the reduction in maximal exercise performance obtained with the different ,B-adrenoceptor antagonists.…”

Section: Heart Ratementioning

confidence: 99%

“…The rise in potassium during exercise is potentiated by non-selective and to a lesser extent by selective 13l-adrenoceptor antagonists (Carlsson et al, 1978;Gullestad et al, 1988Gullestad et al, , 1989aLundborg et al, 1981;McDonald et al, 1984), which has led to the assumption that the exercise-induced increase in potassium by ,B-adrenoceptor antagonists is 32-adrenoceptor dependent.…”

Section: Introductionmentioning

confidence: 99%

Effects of selective beta 2‐adrenoceptor blockade on serum potassium and exercise performance in normal men.

Gullestad

Birkeland

Nordby

et al. 1991

Brit J Clinical Pharma

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3 Cumulative work was significantly reduced by ICI-118551 (6.4%, P = 0.04) and by propranolol (12.4%, P < 0.01), whereas the reduction with atenolol (5.6%) did not reach statistical significance. 4 Atenolol and propranolol reduced peak heart rate by 23% and 29%, and peak systolic blood pressure by 9% and 11% respectively during maximal exercise. ICI-118551 caused a non-significant reduction in heart rate during submaximal exercise, with a significant reduction at maximum exercise (6% reduction), whereas systolic blood pressure was not different from placebo. Diastolic blood pressures were similar across all treatment regimens. 5 Similar glucose concentrations were obtained at baseline and at exhaustion during all treatment regimens. Lactate concentrations were comparable for any given exercise intensity irrespective of treatment regimens. Propranolol reduced lactate concentrations from the exercising muscles at maximum exercise in proportion to the reduction of maximal exercise capacity.6 The subjective perception of fatigue was not affected by either 13l-or P2-adrenoceptor blockade.7 In a separate study, the effects of selective P2-adrenoceptor stimulation (terbutaline) in resting men on heart rate, systolic blood pressure, serum potassium and glucose were completely blocked by the doses of ICI-118551 used in the exercise study.8 We conclude that both ,l-and ,32-adrenoceptors are of importance for maximal short term exercise performance in healthy young men. The decisive mechanism for the reduction in exercise performance during ,-adrenoceptor blockade is unclear.The present study suggests that other mechanisms than haemodynamic and metabolic factors are of importance. The lack of effect of selective ,32-adrenoceptor antagonists on serum potassium at rest and during exercise, and the finding that the rate of decline in the potassium concentrations after exhaustion was independent of treatment regimens, suggests that ,3-adrenoceptors are of minor importance for potassium release or reuptake in the exercising muscle.

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Β-Adrenoceptor BLOCKERS, PLASMA-POTASSIUM, AND EXERCISE

Cited by 123 publications

References 7 publications

A comparison of the effects of flosequinan, a new vasodilator, and propranolol on sub‐maximal exercise in healthy volunteers.

A comparison of the effects of flosequinan, a new vasodilator, and propranolol on sub‐maximal exercise in healthy volunteers.

Potassium and anaesthesia

Effects of selective beta 2‐adrenoceptor blockade on serum potassium and exercise performance in normal men.

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