β-Adrenoceptors in Cancer: Old Players and New Perspectives

Amato, Rosario; Lucchesi, Martina; Marracci, Silvia; Filippi, Luca; Dal Monte, Massimo

doi:10.1007/164_2023_701

Handbook of Experimental Pharmacology

2023

DOI: 10.1007/164_2023_701

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β-Adrenoceptors in Cancer: Old Players and New Perspectives

Rosario Amato,

Martina Lucchesi,

Silvia Marracci

et al.

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2024

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Cited by 1 publication

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Effects of Selective and Nonselective Beta Blockers on Bone Mineral Density in Mexican Patients with Breast Cancer

Mejía-Barradas,

Amador-Martínez,

Lara-Padilla

et al. 2024

Cancers

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Breast cancer (BCa) is related to chronic stress and can reduce the bone mineral density (BMD) through neurochemicals related to beta-adrenergic receptor (ADRB) 1 and 2. Selective beta blockers (sBBs) and nonselective beta blockers (nsBBs) are used to treat systemic arterial hypertension (SAH) and may have osteoprotective effects, as they inhibit ADRBs. To evaluate the effects of sBBs and nsBBs on the BMD of Mexican patients with BCa. A retrospective study was conducted. We included 191 Mexican women with BCa without SAH and with SAH treated with nsBBs, sBBs, and diuretics. BMD was evaluated using a bone density scan (DEX scan). A greater average BMD (p < 0.05) was observed in patients with prior treatment with both nsBBs and sBBs (0.54 ± 0.94 and −0.44 ± 1.22, respectively) compared to patients treated with diuretics or without SAH (−1.73 ± 0.83 and −1.22 ± 0.98, respectively). Regarding the diagnosis of osteoporosis/osteopenia, no cases were observed in patients treated with nsBBs, whereas 5.6% of the patients treated with sBBs presented osteopenia. A total of 23.1% and 10.6% patients managed with diuretics or without treatment presented with osteoporosis and 61.5% and 48% patients managed with loop diuretics and without treatment presented with osteopenia, respectively (p < 0.05). Treatment with nsBBs is a promising option for the prevention and management of osteoporosis/osteopenia in Mexican patients with BCa; however, further prospective studies are needed.

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Effects of Selective and Nonselective Beta Blockers on Bone Mineral Density in Mexican Patients with Breast Cancer

Mejía-Barradas,

Amador-Martínez,

Lara-Padilla

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

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β-Adrenoceptors in Cancer: Old Players and New Perspectives

Cited by 1 publication

References 102 publications

Effects of Selective and Nonselective Beta Blockers on Bone Mineral Density in Mexican Patients with Breast Cancer

Effects of Selective and Nonselective Beta Blockers on Bone Mineral Density in Mexican Patients with Breast Cancer

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