β-adrenoceptors of the infra-limbic cortex mediate corticosterone-induced enhancement of acquisition and consolidation of fear memory extinction in rats

Meamar, Morvarid; Rashidy-Pour, Ali; Vafaei, Abbas Ali; Raise-Abdullahi, Payman

doi:10.1016/j.bbr.2023.114310

Cited by 11 publications

(3 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased sympathetic nervous system activity is a characteristic feature of PTSD, and sympatholytic agents like propranolol have shown effectiveness in alleviating trauma-related nightmares and fear memories associated with the disorder (Meamar et al , 2023;Meister et al , 2023). Adrenaline is known to facilitate the consolidation of memory, which can play a role in the persistence of PTSD symptoms (Hou et al , 2021).…”

Section: Discussionmentioning

confidence: 99%

New recognition of heart-brain axis and its implication in the pathogenesis and treatment of PTSD

Li,

Zhang,

Ding

et al. 2024

Preprint

View full text Add to dashboard Cite

Post-traumatic stress disorder (PTSD) is a complex psychological disorder provoked by distressing experiences, and it remains without highly effective intervention strategies. The exploration of PTSD’s underlying mechanisms is crucial for advancing diagnostic and therapeutic approaches. Current studies primarily explore PTSD through the lens of the CNS, investigating concrete molecular alterations in the cerebral area and neural circuit irregularities. However, the body’s response to external stressors, particularly the changes in cardiovascular function, is often pronounced, evidenced by notable cardiac dysfunction. Consequently, examining PTSD with a focus on cardiac function is vital for the early prevention and targeted management of the disorder. This review undertakes a comprehensive literature analysis to detail the alterations in brain and heart structures and functions associated with PTSD. It also synthesizes potential mechanisms of heart-brain axis interactions relevant to PTSD’s development. Ultimately, by considering cardiac function, this review proposes novel perspectives for PTSD’s prophylaxis and therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

New recognition of heart-brain axis and its implication in the pathogenesis and treatment of PTSD

Li,

Zhang,

Ding

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…BDNF is a neuropeptide crucial for promoting the survival of existing neurons and stimulating the growth and differentiation of new neurons and synapses. Several brain regions are involved in learning and memory as well as higher thinking, such as the prefrontal cortex (PFC), amygdala, hippocampus, and bed nucleus of stria terminalis (Meamar et al., 2023 ; Nazari et al., 2023 ; Omoumi et al., 2023 ). BDNF levels in the PFC have been found to be lower in rats exposed to prolonged maternal separation, a form of early‐life stress that is associated with increased anxiety‐like behaviors (Zhang et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Mild exercise plus levothyroxine ameliorate deficits of spatial navigation, anxiety profile, and hippocampal BDNF in hypothyroid male offspring rats

Boustani,

Rashidy‐Pour,

Bozorgi

et al. 2024

Brain and Behavior

Self Cite

View full text Add to dashboard Cite

PurposeLevothyroxine (LEV) monotherapy cannot completely improve cognitive and behavioral impairments induced by hypothyroidism, whereas a combination therapy of exercise and LEV may ameliorate these deficits. This study aimed to determine the effects of mild‐intensity forced exercise and LEV treatment on the anxiety profile and cognitive functions in male offspring of hypothyroid dams.MethodTwenty‐four female rats (mothers) were randomly divided into sham (healthy) and hypothyroidism groups and then placed with male rats to mate. The presence of vaginal plaque confirmed pregnancy (gestational day, GD 0). 6‐propyl‐2‐thiouracil (PTU, 100 ppm) was added to the drinking water of the hypothyroidism group from GD 6 to the 21st postnatal day (PND). The sham group received tap water. On PND 21, serum T4 levels of mothers, and 10 pups were measured to confirm hypothyroidism. Sixty‐four male pups were left undisturbed for 30 days and then were divided into eight groups that received saline or LEV (50 μg/kg, i.p.) with or without forced mild‐intensity exercise. After 14 days of interventions, anxiety‐like behaviors, spatial learning and memory, and hippocampal brain‐derived neurotrophic factor (BDNF) levels were evaluated.FindingA pre and postnatal PTU‐induced model of hypothyroidism increased anxiety‐like behaviors, impaired spatial learning and memory, and decreased hippocampal BDNF levels in male offspring rats. LEV alone increased BDNF levels and improved spatial learning. Exercise alone increased BDNF levels, improved spatial learning and memory, and decreased anxiety‐like behaviors. Exercise plus LEV more effectively improved anxiety‐like behaviors and spatial learning than exercise or LEV alone.ConclusionPractically, these pre‐clinical findings highlight the importance of the combination of exercise and LEV regimen in treating patients with hyperthyroidism.

show abstract

“…MRs are primarily saturated in basal conditions. GRs are mainly occupied when glucocorticoid circulating levels are high (during the stress and peak of circadian rhythms) [65] and are involved in fear responses and fear memory extinction [66][67][68][69].…”

Section: Figurementioning

confidence: 99%

Hypothalamus and Post-Traumatic Stress Disorder: A Review

et al. 2023

Self Cite

View full text Add to dashboard Cite

Humans have lived in a dynamic environment fraught with potential dangers for thousands of years. While fear and stress were crucial for the survival of our ancestors, today, they are mostly considered harmful factors, threatening both our physical and mental health. Trauma is a highly stressful, often life-threatening event or a series of events, such as sexual assault, war, natural disasters, burns, and car accidents. Trauma can cause pathological metaplasticity, leading to long-lasting behavioral changes and impairing an individual’s ability to cope with future challenges. If an individual is vulnerable, a tremendously traumatic event may result in post-traumatic stress disorder (PTSD). The hypothalamus is critical in initiating hormonal responses to stressful stimuli via the hypothalamic–pituitary–adrenal (HPA) axis. Linked to the prefrontal cortex and limbic structures, especially the amygdala and hippocampus, the hypothalamus acts as a central hub, integrating physiological aspects of the stress response. Consequently, the hypothalamic functions have been attributed to the pathophysiology of PTSD. However, apart from the well-known role of the HPA axis, the hypothalamus may also play different roles in the development of PTSD through other pathways, including the hypothalamic–pituitary–thyroid (HPT) and hypothalamic–pituitary–gonadal (HPG) axes, as well as by secreting growth hormone, prolactin, dopamine, and oxytocin. This review aims to summarize the current evidence regarding the neuroendocrine functions of the hypothalamus, which are correlated with the development of PTSD. A better understanding of the role of the hypothalamus in PTSD could help develop better treatments for this debilitating condition.

show abstract

β-adrenoceptors of the infra-limbic cortex mediate corticosterone-induced enhancement of acquisition and consolidation of fear memory extinction in rats

Cited by 11 publications

References 63 publications

New recognition of heart-brain axis and its implication in the pathogenesis and treatment of PTSD

New recognition of heart-brain axis and its implication in the pathogenesis and treatment of PTSD

Mild exercise plus levothyroxine ameliorate deficits of spatial navigation, anxiety profile, and hippocampal BDNF in hypothyroid male offspring rats

Hypothalamus and Post-Traumatic Stress Disorder: A Review

Contact Info

Product

Resources

About