β-alanine supplementation improves isometric endurance of the knee extensor muscles

Sale, Craig; Hill, CA; Ponte, James; Harris, Roger C.

doi:10.1186/1550-2783-9-26

Cited by 35 publications

(37 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Taking the existing evidence as a whole, the most likely mechanism for an e ect of increased muscle carnosine on exercise performance and capacity remains the e ect it has on intracellular pH bu ering. Lending support to this assertion, studies have examined the e ects of β-alanine on exercise capacity, using tests designed to induce large increases in intramuscular hydrogen cation levels and reductions in pH [11][12]30 , and have shown signi cant increases in exercise capacity. In relation to cycling, studies have shown signi cant e ects of β-alanine supplementation on high-intensity cycling capacity, as determined by increases in total work done [11][12] .…”

Section: Discussionmentioning

confidence: 99%

Effect of β-alanine supplementation on 20 km cycling time trial performance

James

Cooper

Robertson

et al. 2014

Rev. bras. educ. fís. esporte

Self Cite

View full text Add to dashboard Cite

The effects of β-alanine supplementation on high-intensity cycling performance and capacity have been evaluated, although the effects on longer duration cycling performance are unclear. Nineteen UK category 1 male cyclists completed four 20 km cycling time trials, two before and two after supplementation with either 6.4 g•d -1 β-alanine (n = 10; BA) or a matched placebo (n = 9; P). Performance time for the 20 km time trial and 1 km split times were recorded. There was no signifi cant effect of β-alanine supplementation on 20 km time trial performance (BA-pre 1943 ± 129 s; BA-post 1950 ± 147 s; P-pre 1989 ± 106 s; P-post 1986 ± 115 s) or on the performance of each 1 km split. The effect of β-alanine on 20 km time trial performance was deemed unclear as determined by magnitude based inferences. Supplementation with 6.4 g•d -1 of β-alanine for 4 weeks did not affect 20 km cycling time trial performance in well trained male cyclists.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of β-alanine supplementation on 20 km cycling time trial performance

James

Cooper

Robertson

et al. 2014

Rev. bras. educ. fís. esporte

Self Cite

View full text Add to dashboard Cite

show abstract

“…Force output was reduced in the ammonium chloride condition, which coincided with a lower intracellular pH at the end of 75 s of electrical stimulation. Sale et al (2012) have recently shown a 13.2% improvement in isometric knee extensor endurance at 45% of maximal voluntary isometric contraction (MVIC) with beta-alanine supplementation. The increase in intramuscular pressure at 45% MVIC results in occlusion of muscle blood flow, allowing only minimal loss of lactate anions and H + from the contracting muscle.…”

Section: Discussionmentioning

confidence: 99%

Effect of Beta-Alanine With and Without Sodium Bicarbonate on 2,000-m Rowing Performance

Hobson¹,

Harris²,

Martin³

et al. 2013

International Journal of Sport Nutrition and Exercise Metabolism

Self Cite

View full text Add to dashboard Cite

Purpose:To examine the effect of beta-alanine only and beta-alanine with sodium bicarbonate supplementation on 2,000-m rowing performance. Methods: Twenty well-trained rowers (age 23 ± 4 y; height 1.85 ± 0.08 m; body mass 82.5 ± 8.9 kg) were assigned to either a placebo or beta-alanine (6.4 g·d -1 for 4 weeks) group. A 2,000-m rowing time trial (TT) was performed before supplementation (Baseline) and after 28 and 30 days of supplementation. The post supplementation trials involved supplementation with either maltodextrin or sodium bicarbonate in a double-blind, crossover design, creating four study conditions (placebo with maltodextrin; placebo with sodium bicarbonate; beta-alanine with maltodextrin; beta-alanine with sodium bicarbonate). Blood lactate, pH, bicarbonate, and base excess were measured pre-TT, immediately post-TT and at TT+5 min. Performance data were analyzed using magnitude based inferences. Results: Beta-alanine supplementation was very likely to be beneficial to 2,000-m rowing performance (6.4 ± 8.1 s effect compared with placebo), with the effect of sodium bicarbonate having a likely benefit (3.2 ± 8.8 s). There was a small (1.1 ± 5.6 s) but possibly beneficial additional effect when combining chronic beta-alanine supplementation with acute sodium bicarbonate supplementation compared with chronic beta-alanine supplementation alone. Sodium bicarbonate ingestion led to increases in plasma pH, base excess, bicarbonate, and lactate concentrations. Conclusions: Both chronic beta-alanine and acute sodium bicarbonate supplementation alone had positive effects on 2,000-m rowing performance. The addition of acute sodium bicarbonate to chronic beta-alanine supplementation may further enhance rowing performance.

show abstract

“…Anaerobic glycolysis involves the rapid breakdown of glucose into lactate within the cytosol of the cell. This lactate production results in the dissociation of hydrogen ions accounting for the generation of more than 94% of the total hydrogen ion concentration within skeletal muscle, causing a dramatic decline in intramuscular pH [12,21]. This reduction in pH will eventually overwhelm the cell's buffering capacity, resulting in acidosis, hindering the ability of the muscle to continue to contract, resulting in muscular fatigue and a decline in performance [21].…”

Section: Introductionmentioning

confidence: 99%

“…This lactate production results in the dissociation of hydrogen ions accounting for the generation of more than 94% of the total hydrogen ion concentration within skeletal muscle, causing a dramatic decline in intramuscular pH [12,21]. This reduction in pH will eventually overwhelm the cell's buffering capacity, resulting in acidosis, hindering the ability of the muscle to continue to contract, resulting in muscular fatigue and a decline in performance [21]. Physiochemical buffers within the cell, specifically carnosine, provide the primary mechanism for buffering these liberated ions, delaying the onset of acidosis and aiding in performance [22,23].…”

Section: Introductionmentioning

confidence: 99%

Influence of Sustained Beta-Alanine Supplementation on Body Composition and Physical Performance in College-aged Males Seeking Military Commission

Jaffe¹,

Hewit²,

Cholewa³

et al. 2018

saj

View full text Add to dashboard Cite

The present study was designed to investigate the effects of chronic ingestion of a proprietary beta-alanine supplement on body composition, indices of strength and power performance, and markers of cardiovascular endurance in physically active, college-aged males commissioning within the armed services. Subjects (n = 30) participated in four separate testing sessions, both pre and post assessment consuming either 6.0 g/day beta-alanine or Placebo supplementation for 6 weeks. Parameters evaluated included body fat percentage (BF%), fat free mass (FFM), vertical jump (VJ), 1 repetition maximum back squat (SQ) and bench press (BP), and a repetition maximum bench press (RMBP) at 75% of the attained maximum, maximal oxygen consumption (VO 2peak), respiratory exchange ratio (RER), lactate threshold (LT), and peak lactate concentration. For all variables, no significant interactions existed across condition and time (p > .05). In addition, for all variables, no significant differences existed between conditions (p > .05). Beta-alanine did not show any benefit for improving body composition or physical performance parameters in this group of individuals.

show abstract

β-alanine supplementation improves isometric endurance of the knee extensor muscles

Cited by 35 publications

References 32 publications

Effect of β-alanine supplementation on 20 km cycling time trial performance

Effect of β-alanine supplementation on 20 km cycling time trial performance

Effect of Beta-Alanine With and Without Sodium Bicarbonate on 2,000-m Rowing Performance

Influence of Sustained Beta-Alanine Supplementation on Body Composition and Physical Performance in College-aged Males Seeking Military Commission

Contact Info

Product

Resources

About