2015
DOI: 10.1038/ncomms8369
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β-Arrestin1 enhances hepatocellular carcinogenesis through inflammation-mediated Akt signalling

Abstract: G-protein-coupled receptors (GPCR) constitute the largest known superfamily for signal transduction and transmission, and they control a variety of physiological and pathological processes. GPCR adaptor b-arrestins (ARRBs) play a role in cancerous proliferation. However, the effect of ARRBs in inflammation-mediated hepatocellular carcinogenesis is unknown. Here we show that ARRB1, but not ARRB2, is upregulated in inflammation-associated hepatocellular carcinoma (HCC) and paracancerous tissues in humans. A geno… Show more

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Cited by 64 publications
(102 citation statements)
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“…So far, researches about β-arrestin 1 in different types of cancer mainly focused on the role of its total form [20][21][22][23]. However, phosphorylation of β-arrestin 1 mediates multiple biological functions [24,25].…”
Section: Discussionmentioning
confidence: 99%
“…So far, researches about β-arrestin 1 in different types of cancer mainly focused on the role of its total form [20][21][22][23]. However, phosphorylation of β-arrestin 1 mediates multiple biological functions [24,25].…”
Section: Discussionmentioning
confidence: 99%
“…Increasing evidence indicates that the aberrant activation of AKT1 is a key oncogenic event in human hepatocarcinogenesis30. Specifically, cell- and animal-based experiments show that AKT1 interacts with several HBV proteins to contribute to deterioration in liver disease31.…”
Section: Discussionmentioning
confidence: 99%
“…For drug administration, TNF‐α (Sigma, St Louis, MO, USA) was dissolved in DMEM and added at different concentrations or time points after the cells reached 90% confluence. For siRNA treatment, HepG2 and Huh7 cells were transfected with PTTG1‐siRNA according to a previously described protocol . The PTTG1‐siRNA sequences are 5′‐GGGAAUCCAAUCUGUUGCATT‐3′ (sense) and 5′‐UGCAACAGAUUGGAUUCCCTT‐3′ (antisense).…”
Section: Methodsmentioning
confidence: 99%