β-asarone improves cognitive impairment and alleviates autophagy in mice with vascular dementia via the cAMP/PKA/CREB pathway

Ning, Zhenqiu; Zhong, Xiaoqin; Wu, Yanan; Wang, Yu; Hu, Dafeng; Wang, Kai; Deng, Minzhen

doi:10.1016/j.phymed.2023.155215

Cited by 6 publications

(2 citation statements)

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“…Recent studies have identified a strong interaction between EV-A71 3D pol and autophagy. Beclin1 is an autophagy protein that regulates innate immune pathways [ 51 , 52 ]. RNA interference and overexpression experiments showed that the expression level of Beclin1 and EV-A71 replication were positively correlated [ 53 ], suggesting that EV-A71 infection can induce autophagy to enhance viral replication [ 54 , 55 ].…”

Section: Advances In Picornavirus 3d Pol -Host Int...mentioning

confidence: 99%

The multiple roles of viral 3D ^pol protein in picornavirus infections

Nie,

Zhai,

Zhang

et al. 2024

Virulence

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The Picornaviridae are a large group of positive-sense, single-stranded RNA viruses, and most research has focused on the Enterovirus genus, given they present a severe health risk to humans. Other picornaviruses, such as foot-and-mouth disease virus (FMDV) and senecavirus A (SVA), affect agricultural production with high animal mortality to cause huge economic losses. The 3D pol protein of picornaviruses is widely known to be used for genome replication; however, a growing number of studies have demonstrated its non-polymerase roles, including modulation of host cell biological processes, viral replication complex assembly and localization, autophagy, and innate immune responses. Currently, there is no effective vaccine to control picornavirus diseases widely, and clinical therapeutic strategies have limited efficiency in combating infections. Many efforts have been made to develop different types of drugs to prohibit virus survival; the most important target for drug development is the virus polymerase, a necessary element for virus replication. For picornaviruses, there are also active efforts in targeted 3D pol drug development. This paper reviews the interaction of 3D pol proteins with the host and the progress of drug development targeting 3D pol .

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Section: Advances In Picornavirus 3d Pol -Host Int...mentioning

confidence: 99%

The multiple roles of viral 3D ^pol protein in picornavirus infections

Nie,

Zhai,

Zhang

et al. 2024

Virulence

View full text Add to dashboard Cite

show abstract

“…In a recent analysis using the network pharmacology computational approach and molecular docking, Ning et al [131] individuated RELA, a subunit of the NF-κB complex, as a possible target of β-asarone [131]. Interestingly, at the highest dosage, β-asarone could significantly reduce RELA mRNA expression in a vascular dementia mouse model [131]. Brain injury after sub-…”

Section: Acorus Tatarinowii Eomentioning

confidence: 99%

Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases

Avola,

Furnari,

Graziano

et al. 2024

Antioxidants

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Neuroinflammation, a pivotal factor in the pathogenesis of various brain disorders, including neurodegenerative diseases, has become a focal point for therapeutic exploration. This review highlights neuroinflammatory mechanisms that hallmark neurodegenerative diseases and the potential benefits of essential oils in counteracting neuroinflammation and oxidative stress, thereby offering a novel strategy for managing and mitigating the impact of various brain disorders. Essential oils, derived from aromatic plants, have emerged as versatile compounds with a myriad of health benefits. Essential oils exhibit robust antioxidant activity, serving as scavengers of free radicals and contributing to cellular defense against oxidative stress. Furthermore, essential oils showcase anti-inflammatory properties, modulating immune responses and mitigating inflammatory processes implicated in various chronic diseases. The intricate mechanisms by which essential oils and phytomolecules exert their anti-inflammatory and antioxidant effects were explored, shedding light on their multifaceted properties. Notably, we discussed their ability to modulate diverse pathways crucial in maintaining oxidative homeostasis and suppressing inflammatory responses, and their capacity to rescue cognitive deficits observed in preclinical models of neurotoxicity and neurodegenerative diseases.

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Taohong Siwu decoction alleviates cognitive impairment by suppressing endoplasmic reticulum stress and apoptosis signaling pathway in vascular dementia rats

Fan,

Fang,

Zheng

et al. 2024

Journal of Ethnopharmacology

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β-asarone improves cognitive impairment and alleviates autophagy in mice with vascular dementia via the cAMP/PKA/CREB pathway

Cited by 6 publications

References 58 publications

The multiple roles of viral 3D ^pol protein in picornavirus infections

The multiple roles of viral 3D ^pol protein in picornavirus infections

Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases

Taohong Siwu decoction alleviates cognitive impairment by suppressing endoplasmic reticulum stress and apoptosis signaling pathway in vascular dementia rats

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β-asarone improves cognitive impairment and alleviates autophagy in mice with vascular dementia via the cAMP/PKA/CREB pathway

Cited by 6 publications

References 58 publications

The multiple roles of viral 3D pol protein in picornavirus infections

The multiple roles of viral 3D pol protein in picornavirus infections

Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases

Taohong Siwu decoction alleviates cognitive impairment by suppressing endoplasmic reticulum stress and apoptosis signaling pathway in vascular dementia rats

Contact Info

Product

Resources

About

The multiple roles of viral 3D ^pol protein in picornavirus infections

The multiple roles of viral 3D ^pol protein in picornavirus infections