β-cantenin is potentially involved in the regulation of c-Jun signaling following bovine herpesvirus 1 infection

Chang, Long; Yuan, Weifeng; Zhu, Liqian

doi:10.1016/j.vetmic.2020.108804

Cited by 5 publications

(1 citation statement)

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“…β-catenin signaling is essential for cell survival [ 47 ]. iCRT14 at a concentration of 10 μM did not show cytotoxicity to MDBK cells in the absence of virus infection as we described elsewhere [ 48 ]. Here, we found that apoptotic bodies are readily detected in virus-infected cells in the presence of iCRT14 ( Figure 5 , numbered 1 to 3), suggesting that apoptosis is induced in virus-infected cells by iCRT14.…”

Section: Resultsmentioning

confidence: 74%

β-catenin has potential effects on the expression, subcellular localization, and release of high mobility group box 1 during bovine herpesvirus 1 productive infection in MDBK cell culture

et al. 2021

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High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, can be released into extracellular space and function as a strong proinflammatory cytokine, which plays critical roles in the pathogenesis of various inflammatory diseases. Here, we showed that BoHV-1 productive infection in MDBK cells at later stage significantly increases HMGB1 mRNA expression and the protein release, but decreases the steady-state protein levels. Virus infection increases accumulation of HMGB1 protein in both nucleus and mitochondria, and relocalizes nuclear HMGB1 to assemble in highlighted foci via a confocal microscope assay. Interestingly, β-catenin-specific inhibitor iCRT14 is able to increase HMGB1 transcription and the protein release, and subcellular translocation in virus-infected cells. HMGB1-specific inhibitor, glycyrrhizin, could differentially affect virus gene transcription such as, the viral regulatory protein bICP0, bICP4 and bICP22, as well as glycoprotein gD. In summary, our data provides a novel mechanism that β-catenin signaling may regulate inflammatory response via affecting HMGB1 signaling.

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Section: Resultsmentioning

confidence: 74%