β-carotene improves fecal dysbiosis and intestinal dysfunctions in a mouse model of vitamin A deficiency

Honarbakhsh, Maryam; Malta, Kiana; Ericsson, Aaron C.; Holloway, Chelsee; Kim, Youn‐Kyung; Hämmerling, Ulrich; Quadro, Loredana

doi:10.1016/j.bbalip.2022.159122

Cited by 19 publications

(10 citation statements)

References 74 publications

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“…It accomplishes this by enhancing mucin expression, reducing the presence of inflammatory cytokines, and ameliorating dysbiosis caused by vitamin A deficiency, as supported by prior research. 51 Considering these findings, it is reasonable to suggest that the favorable effects of FGJ on the gut microbiota may be attributed to not only the presence of probiotics but also the potential role of β-carotene in stimulating SCFA production and shaping gut microbiota composition.…”

Section: Resultsmentioning

confidence: 97%

Modulation of the gut microbiota and short-chain fatty acid production by gac fruit juice and its fermentation in in vitro colonic fermentation

Marnpae,

Balmori,

Kamonsuwan

et al. 2024

Food Funct.

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Section: Resultsmentioning

confidence: 97%

Modulation of the gut microbiota and short-chain fatty acid production by gac fruit juice and its fermentation in in vitro colonic fermentation

Marnpae,

Balmori,

Kamonsuwan

et al. 2024

Food Funct.

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“…The present result is in harmony with the earlier results of Trivedi and Jena [ 41 ], who showed that β-carotene administration decreased inflammation combined with ulcerative colitis in mice by lowering the colonic contents of immunomodulatory cytokines IL-17, IL-6, and TNFα. In the mouse model of vitamin A deficiency, supplementation of β-carotene also downregulated the levels of intestinal inflammatory cytokines, TNFα, IL1-β, and IL-6, and immunomodulatory cytokines, IL22, IL23, and IL17 [ 42 ]. Similarly, β-carotene controlled the contents of immunomodulatory cytokines IL-17 and IL-22, prospective regulators of prolonged inflammation in the intestinal tract [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Natural β-carotene prevents acute lung injury induced by cyclophosphamide in mice

et al. 2023

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IL-17 is associated with varied inflammatory and immune-related diseases. However, the biological function of IL-17 and its expression in acute lung damage are not entirely known. Thanks to the powerful antioxidant properties of β-carotene, we presumed that it would show a potent protecting effect against cyclophosphamide (CP) -induced acute lung injury (ALI) in mice. We studied the mechanisms underlying the effect of β-carotene supplementation against CP-induced ALI in mice. We isolated the β-carotene from Scenedesmus obliquus microalgae n-hexane extract and identified it by HPLC and 1H-NMR analysis. Within the experiments, 40 mice were assigned into five groups randomly: Group 1 (Control): Mice received saline. Group 2 (β-carotene control): Mice were administered β-carotene (40 mg/kg; orally) once daily for 10 sequent days without CP injection. Group 3 (CP): One i.p injection of 200 (mg/kg) of CP was given to mice. Group 4 and 5 (CP + β-carotene): Mice were administered β-carotene (20 and 40 mg/kg; orally) once a day for ten days following the CP injection. Lung samples were collected for lab analysis, after scarifying the animals at the experiment end. Administration of β-carotene orally reduced CP-induced ALI and inflammation. β-carotene significantly decreased wet-to-dry weight ratios (W/D), down-regulated IL-17, NF-κB, and IKBKB, decreased the contents of TNF-α, COX-2, and PKC, and increased the contents of SIRT1 and PPARγ in the lung tissues. β-carotene ameliorated the histopathological changes induced by CP and reduced the scoring number of inflammatory cell infiltration and emphysema when compared to CP. Consequently, we conclude natural β-carotene is a promising anti-inflammatory mediator for different inflammatory-related complications.

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“…Subclinical vitamin A deficiency is linked to a worsened outcome and disease course and is closely linked to iron deficiency and to inflammation (156)(157)(158). Retinol is mobilized from the liver by an iron-dependent enzyme (159), with irondeficient conditions hindering the mobilization of this vitamin.…”

Section: Vitamin Amentioning

confidence: 99%

Lack of iron, zinc, and vitamins as a contributor to the etiology of atopic diseases

et al. 2023

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Micronutritional deficiencies are common in atopic children suffering from atopic dermatitis, food allergy, rhinitis, and asthma. A lack of iron, in particular, may impact immune activation with prolonged deficiencies of iron, zinc, vitamin A, and vitamin D associated with a Th2 signature, maturation of macrophages and dendritic cells (DCs), and the generation of IgE antibodies. In contrast, the sufficiency of these micronutrients establishes immune resilience, promotion of regulatory cells, and tolerance induction. As micronutritional deficiencies mimic an infection, the body’s innate response is to limit access to these nutrients and also impede their dietary uptake. Here, we summarize our current understanding of the physiological function of iron, zinc, and vitamins A and D in relation to immune cells and the clinical consequences of deficiencies in these important nutrients, especially in the perinatal period. Improved dietary uptake of iron is achieved by vitamin C, vitamin A, and whey compounds, whereas zinc bioavailability improves through citrates and proteins. The addition of oil is essential for the dietary uptake of beta-carotene and vitamin D. As for vitamin D, the major source comes via sun exposure and only a small amount is consumed via diet, which should be factored into clinical nutritional studies. We summarize the prevalence of micronutritional deficiencies of iron, zinc, and vitamins in the pediatric population as well as nutritional intervention studies on atopic diseases with whole food, food components, and micronutrients. Dietary uptake via the lymphatic route seems promising and is associated with a lower atopy risk and symptom amelioration. This review provides useful information for clinical studies and concludes/emphasizes that a healthy, varied diet containing dairy products, fish, nuts, fruits, and vegetables as well as supplementing foods or supplementation with micronutrients as needed is essential to combat the atopic march.

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β-carotene improves fecal dysbiosis and intestinal dysfunctions in a mouse model of vitamin A deficiency

Cited by 19 publications

References 74 publications

Modulation of the gut microbiota and short-chain fatty acid production by gac fruit juice and its fermentation in in vitro colonic fermentation

Modulation of the gut microbiota and short-chain fatty acid production by gac fruit juice and its fermentation in in vitro colonic fermentation

Natural β-carotene prevents acute lung injury induced by cyclophosphamide in mice

Lack of iron, zinc, and vitamins as a contributor to the etiology of atopic diseases

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